Molecular Mechanisms of Muscle Weakness Associated with E173A Mutation in Tpm3.12. Troponin Ca(2+) Sensitivity Inhibitor W7 Can Reduce the Damaging Effect of This Mutation

Substitution of Ala for Glu residue in position 173 of γ-tropomyosin (Tpm3.12) is associated with muscle weakness. Here we observe that this mutation increases myofilament Ca(2+)-sensitivity and inhibits in vitro actin-activated ATPase activity of myosin subfragment-1 at high Ca(2+). In order to det...

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Detalles Bibliográficos
Autores principales: Borovikov, Yurii S., Simonyan, Armen O., Avrova, Stanislava V., Sirenko, Vladimir V., Redwood, Charles S., Karpicheva, Olga E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352912/
https://www.ncbi.nlm.nih.gov/pubmed/32580284
http://dx.doi.org/10.3390/ijms21124421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352912/
https://www.ncbi.nlm.nih.gov/pubmed/32580284
http://dx.doi.org/10.3390/ijms21124421

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