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Molecular Mechanisms of Muscle Weakness Associated with E173A Mutation in Tpm3.12. Troponin Ca(2+) Sensitivity Inhibitor W7 Can Reduce the Damaging Effect of This Mutation
Substitution of Ala for Glu residue in position 173 of γ-tropomyosin (Tpm3.12) is associated with muscle weakness. Here we observe that this mutation increases myofilament Ca(2+)-sensitivity and inhibits in vitro actin-activated ATPase activity of myosin subfragment-1 at high Ca(2+). In order to det...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352912/ https://www.ncbi.nlm.nih.gov/pubmed/32580284 http://dx.doi.org/10.3390/ijms21124421 |