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Controlled Release of Therapeutics from Thermoresponsive Nanogels: A Thermal Magnetic Resonance Feasibility Study

Thermal magnetic resonance (ThermalMR) accommodates radio frequency (RF)-induced temperature modulation, thermometry, anatomic and functional imaging, and (nano)molecular probing in an integrated RF applicator. This study examines the feasibility of ThermalMR for the controlled release of a model th...

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Autores principales: Ji, Yiyi, Winter, Lukas, Navarro, Lucila, Ku, Min-Chi, Periquito, João S., Pham, Michal, Hoffmann, Werner, Theune, Loryn E., Calderón, Marcelo, Niendorf, Thoralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352924/
https://www.ncbi.nlm.nih.gov/pubmed/32471299
http://dx.doi.org/10.3390/cancers12061380
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author Ji, Yiyi
Winter, Lukas
Navarro, Lucila
Ku, Min-Chi
Periquito, João S.
Pham, Michal
Hoffmann, Werner
Theune, Loryn E.
Calderón, Marcelo
Niendorf, Thoralf
author_facet Ji, Yiyi
Winter, Lukas
Navarro, Lucila
Ku, Min-Chi
Periquito, João S.
Pham, Michal
Hoffmann, Werner
Theune, Loryn E.
Calderón, Marcelo
Niendorf, Thoralf
author_sort Ji, Yiyi
collection PubMed
description Thermal magnetic resonance (ThermalMR) accommodates radio frequency (RF)-induced temperature modulation, thermometry, anatomic and functional imaging, and (nano)molecular probing in an integrated RF applicator. This study examines the feasibility of ThermalMR for the controlled release of a model therapeutics from thermoresponsive nanogels using a 7.0-tesla whole-body MR scanner en route to local drug-delivery-based anticancer treatments. The capacity of ThermalMR is demonstrated in a model system involving the release of fluorescein-labeled bovine serum albumin (BSA-FITC, a model therapeutic) from nanometer-scale polymeric networks. These networks contain thermoresponsive polymers that bestow environmental responsiveness to physiologically relevant changes in temperature. The release profile obtained for the reference data derived from a water bath setup used for temperature stimulation is in accordance with the release kinetics deduced from the ThermalMR setup. In conclusion, ThermalMR adds a thermal intervention dimension to an MRI device and provides an ideal testbed for the study of the temperature-induced release of drugs, magnetic resonance (MR) probes, and other agents from thermoresponsive carriers. Integrating diagnostic imaging, temperature intervention, and temperature response control, ThermalMR is conceptually appealing for the study of the role of temperature in biology and disease and for the pursuit of personalized therapeutic drug delivery approaches for better patient care.
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spelling pubmed-73529242020-07-15 Controlled Release of Therapeutics from Thermoresponsive Nanogels: A Thermal Magnetic Resonance Feasibility Study Ji, Yiyi Winter, Lukas Navarro, Lucila Ku, Min-Chi Periquito, João S. Pham, Michal Hoffmann, Werner Theune, Loryn E. Calderón, Marcelo Niendorf, Thoralf Cancers (Basel) Article Thermal magnetic resonance (ThermalMR) accommodates radio frequency (RF)-induced temperature modulation, thermometry, anatomic and functional imaging, and (nano)molecular probing in an integrated RF applicator. This study examines the feasibility of ThermalMR for the controlled release of a model therapeutics from thermoresponsive nanogels using a 7.0-tesla whole-body MR scanner en route to local drug-delivery-based anticancer treatments. The capacity of ThermalMR is demonstrated in a model system involving the release of fluorescein-labeled bovine serum albumin (BSA-FITC, a model therapeutic) from nanometer-scale polymeric networks. These networks contain thermoresponsive polymers that bestow environmental responsiveness to physiologically relevant changes in temperature. The release profile obtained for the reference data derived from a water bath setup used for temperature stimulation is in accordance with the release kinetics deduced from the ThermalMR setup. In conclusion, ThermalMR adds a thermal intervention dimension to an MRI device and provides an ideal testbed for the study of the temperature-induced release of drugs, magnetic resonance (MR) probes, and other agents from thermoresponsive carriers. Integrating diagnostic imaging, temperature intervention, and temperature response control, ThermalMR is conceptually appealing for the study of the role of temperature in biology and disease and for the pursuit of personalized therapeutic drug delivery approaches for better patient care. MDPI 2020-05-27 /pmc/articles/PMC7352924/ /pubmed/32471299 http://dx.doi.org/10.3390/cancers12061380 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ji, Yiyi
Winter, Lukas
Navarro, Lucila
Ku, Min-Chi
Periquito, João S.
Pham, Michal
Hoffmann, Werner
Theune, Loryn E.
Calderón, Marcelo
Niendorf, Thoralf
Controlled Release of Therapeutics from Thermoresponsive Nanogels: A Thermal Magnetic Resonance Feasibility Study
title Controlled Release of Therapeutics from Thermoresponsive Nanogels: A Thermal Magnetic Resonance Feasibility Study
title_full Controlled Release of Therapeutics from Thermoresponsive Nanogels: A Thermal Magnetic Resonance Feasibility Study
title_fullStr Controlled Release of Therapeutics from Thermoresponsive Nanogels: A Thermal Magnetic Resonance Feasibility Study
title_full_unstemmed Controlled Release of Therapeutics from Thermoresponsive Nanogels: A Thermal Magnetic Resonance Feasibility Study
title_short Controlled Release of Therapeutics from Thermoresponsive Nanogels: A Thermal Magnetic Resonance Feasibility Study
title_sort controlled release of therapeutics from thermoresponsive nanogels: a thermal magnetic resonance feasibility study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352924/
https://www.ncbi.nlm.nih.gov/pubmed/32471299
http://dx.doi.org/10.3390/cancers12061380
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