Cargando…

Triarylpyridine Compounds and Chloroquine Act in Concert to Trigger Lysosomal Membrane Permeabilization and Cell Death in Cancer Cells

Lysosomes play a key role in regulating cell death in response to cancer therapies, yet little is known on the possible role of lysosomes in the therapeutic efficacy of G-quadruplex DNA ligands (G4L) in cancer cells. Here, we investigate the relationship between the modulation of lysosomal membrane...

Descripción completa

Detalles Bibliográficos
Autores principales:	Beauvarlet, Jennifer, Nath Das, Rabindra, Alvarez-Valadez, Karla, Martins, Isabelle, Muller, Alexandra, Darbo, Elodie, Richard, Elodie, Soubeyran, Pierre, Kroemer, Guido, Guillon, Jean, Mergny, Jean-Louis, Djavaheri-Mergny, Mojgan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352983/ https://www.ncbi.nlm.nih.gov/pubmed/32570977 http://dx.doi.org/10.3390/cancers12061621

Ejemplares similares

Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells
por: Beauvarlet, Jennifer, et al.
Publicado: (2019)

Targeting CAMKK2 and SOC Channels as a Novel Therapeutic Approach for Sensitizing Acute Promyelocytic Leukemia Cells to All-Trans Retinoic Acid
por: Merhi, Faten, et al.
Publicado: (2021)

Exploring the Complex Link between Autophagy, Regulated Cell Death, and Cell Fate Pathways in Cancer Pathogenesis and Therapy
por: Moosavi, Mohammad Amin, et al.
Publicado: (2023)

Autophagy: New Insights into Mechanisms of Action and Resistance of Treatment in Acute Promyelocytic leukemia
por: Moosavi, Mohammad Amin, et al.
Publicado: (2019)

Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells
por: Ségal-Bendirdjian, Evelyne, et al.
Publicado: (2014)

Design, Synthesis and Biological Evaluation of New Substituted Diquinolinyl-Pyridine Ligands as Anticancer Agents by Targeting G-Quadruplex
por: Das, Rabindra Nath, et al.
Publicado: (2017)

Therapeutic Modulation of Autophagy in Leukaemia and Lymphoma
por: Djavaheri-Mergny, Mojgan, et al.
Publicado: (2019)

TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex
por: Airiau, Kelly, et al.
Publicado: (2021)

Lysosomal Membrane Permeabilization Induces Cell Death in a Mitochondrion-dependent Fashion
por: Boya, Patricia, et al.
Publicado: (2003)

The CDT of Helicobacter hepaticus induces pro-survival autophagy and nucleoplasmic reticulum formation concentrating the RNA binding proteins UNR/CSDE1 and P62/SQSTM1
por: He, Wencan, et al.
Publicado: (2021)

Erratum: Rémy et al. Isolation and Culture of Human Stem Cells from Apical Papilla under Low Oxygen Concentration Highlight Original Properties. Cells 2019, 8, 1485
por: Rémy, Murielle, et al.
Publicado: (2021)

Isolation and Culture of Human Stem Cells from Apical Papilla under Low Oxygen Concentration Highlight Original Properties
por: Rémy, Murielle, et al.
Publicado: (2019)

Regulation of apoptosis-associated lysosomal membrane permeabilization
por: Johansson, Ann-Charlotte, et al.
Publicado: (2010)

Contribution of Particle-Induced Lysosomal Membrane Hyperpolarization to Lysosomal Membrane Permeabilization
por: Ziglari, Tahereh, et al.
Publicado: (2021)

ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis
por: Motiño, Omar, et al.
Publicado: (2022)

DRAM Triggers Lysosomal Membrane Permeabilization and Cell Death in CD4(+) T Cells Infected with HIV
por: Laforge, Mireille, et al.
Publicado: (2013)

Galactosyl- and glucosylsphingosine induce lysosomal membrane permeabilization and cell death in cancer cells
por: Stahl-Meyer, Kamilla, et al.
Publicado: (2022)

Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1
por: Vanwalleghem, Gilles, et al.
Publicado: (2015)

Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy
por: Halaby, Reginald
Publicado: (2021)

Synthesis of triarylpyridines with sulfonate and sulfonamide moieties via a cooperative vinylogous anomeric-based oxidation
por: Torabi, Morteza, et al.
Publicado: (2021)

PIG7 promotes leukemia cell chemosensitivity via lysosomal membrane permeabilization
por: Liu, Jiazhuo, et al.
Publicado: (2015)

Shape matters: size-exclusion HPLC for the study of nucleic acid structural polymorphism
por: Largy, Eric, et al.
Publicado: (2014)

Effect of glutamate on lysosomal membrane permeabilization in primary cultured cortical neurons
por: YAN, MIN, et al.
Publicado: (2016)

Synthesis of an Hsp70 inhibitor and its assessment of lysosomal membrane permeabilization
por: Park, Sang-Hyun, et al.
Publicado: (2021)

Real-Time Monitoring of Lysosomal Membrane Permeabilization Using Acridine Orange
por: Eriksson, Ida, et al.
Publicado: (2023)

A self-assembled nanophotosensitizer targets lysosomes and induces lysosomal membrane permeabilization to enhance photodynamic therapy
por: Li, Youyou, et al.
Publicado: (2023)

Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization
por: Nylandsted, Jesper, et al.
Publicado: (2004)

MUC1c Regulates Cell Survival in Pancreatic Cancer by Preventing Lysosomal Permeabilization
por: Banerjee, Sulagna, et al.
Publicado: (2012)

(-)-Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization
por: LeGendre, Onica, et al.
Publicado: (2015)

(-)-Oleocanthal and (-)-oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells
por: Goren, Limor, et al.
Publicado: (2019)

Quadruplex ligands may act as molecular chaperones for tetramolecular quadruplex formation
por: Cian, Anne De, et al.
Publicado: (2007)

Pterostilbene-Induced Tumor Cytotoxicity: A Lysosomal Membrane Permeabilization-Dependent Mechanism
por: Mena, Salvador, et al.
Publicado: (2012)

Increased Lysosomal Membrane Permeabilization in Oxidant-exposed Macrophages of Human Fibrotic Lungs
por: Persson, Hans L, et al.
Publicado: (2013)

Changes of lysosomal membrane permeabilization and lipid metabolism in sidt2 deficient mice
por: Meng, Yu, et al.
Publicado: (2018)

Suppressing UVRAG Induces Radiosensitivity by Triggering Lysosomal Membrane Permeabilization in Hypopharyngeal Squamous Cell Carcinoma
por: Wang, Jianwen, et al.
Publicado: (2020)

Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells
por: Cash, Timothy P., et al.
Publicado: (2020)

Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells
por: Zhang, Kevin R., et al.
Publicado: (2023)

Cytolethal distending toxin induces the formation of transient messenger-rich ribonucleoprotein nuclear invaginations in surviving cells
por: Azzi-Martin, Lamia, et al.
Publicado: (2019)

The effect of chemical modifications on the thermal stability of different G-quadruplex-forming oligonucleotides
por: Saccà, Barbara, et al.
Publicado: (2005)

Stability of intramolecular quadruplexes: sequence effects in the central loop
por: Guédin, Aurore, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_jlv1ujbgpl7hpmsgqjfge54k99