Whole Exome Sequencing of Multi-Regional Biopsies from Metastatic Lesions to Evaluate Actionable Truncal Mutations Using a Single-Pass Percutaneous Technique

We investigate the feasibility of obtaining multiple spatially-separated biopsies from a single lesion to explore intratumor heterogeneity and identify actionable truncal mutations using whole exome sequencing (WES). A single-pass radiologically-guided percutaneous technique was used to obtain four...

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Detalles Bibliográficos
Autores principales: Heong, Valerie, Tay, Darwin, Goh, Shane Ee, Wee, Bernard, Tan, Tuan Zea, Soo, Ross, Pang, Brendan, Lim, Diana, Gopinathan, Anil, Ow, Samuel, Chee, Cheng Ean, Goh, Boon Cher, Lee, Soo Chin, Yong, Wei Peng, Wong, Andrea, Omar, Mohamed Feroz Mohd, Soong, Richie, Tan, David S.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353029/
https://www.ncbi.nlm.nih.gov/pubmed/32560395
http://dx.doi.org/10.3390/cancers12061599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353029/
https://www.ncbi.nlm.nih.gov/pubmed/32560395
http://dx.doi.org/10.3390/cancers12061599

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