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Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer
Estrogen receptors (ERα and ERβ) are ligand-activated transcription factors that play different roles in gene regulation and show both overlapping and specific tissue distribution patterns. ERβ, contrary to the oncogenic ERα, has been shown to act as an oncosuppressor in several instances. However,...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353068/ https://www.ncbi.nlm.nih.gov/pubmed/32516978 http://dx.doi.org/10.3390/cancers12061477 |
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author | Sellitto, Assunta D’Agostino, Ylenia Alexandrova, Elena Lamberti, Jessica Pecoraro, Giovanni Memoli, Domenico Rocco, Domenico Coviello, Elena Giurato, Giorgio Nassa, Giovanni Tarallo, Roberta Weisz, Alessandro Rizzo, Francesca |
author_facet | Sellitto, Assunta D’Agostino, Ylenia Alexandrova, Elena Lamberti, Jessica Pecoraro, Giovanni Memoli, Domenico Rocco, Domenico Coviello, Elena Giurato, Giorgio Nassa, Giovanni Tarallo, Roberta Weisz, Alessandro Rizzo, Francesca |
author_sort | Sellitto, Assunta |
collection | PubMed |
description | Estrogen receptors (ERα and ERβ) are ligand-activated transcription factors that play different roles in gene regulation and show both overlapping and specific tissue distribution patterns. ERβ, contrary to the oncogenic ERα, has been shown to act as an oncosuppressor in several instances. However, while the tumor-promoting actions of ERα are well-known, the exact role of ERβ in carcinogenesis and tumor progression is not yet fully understood. Indeed, to date, highly variable and even opposite effects have been ascribed to ERβ in cancer, including for example both proliferative and growth-inhibitory actions. Recently ERβ has been proposed as a potential target for cancer therapy, since it is expressed in a variety of breast cancers (BCs), including triple-negative ones (TNBCs). Because of the dependence of TNBCs on active cellular signaling, numerous studies have attempted to unravel the mechanism(s) behind ERβ-regulated gene expression programs but the scenario has not been fully revealed. We comprehensively reviewed the current state of knowledge concerning ERβ role in TNBC biology, focusing on the different signaling pathways and cellular processes regulated by this transcription factor, as they could be useful in identifying new diagnostic and therapeutic approaches for TNBC. |
format | Online Article Text |
id | pubmed-7353068 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73530682020-07-15 Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer Sellitto, Assunta D’Agostino, Ylenia Alexandrova, Elena Lamberti, Jessica Pecoraro, Giovanni Memoli, Domenico Rocco, Domenico Coviello, Elena Giurato, Giorgio Nassa, Giovanni Tarallo, Roberta Weisz, Alessandro Rizzo, Francesca Cancers (Basel) Review Estrogen receptors (ERα and ERβ) are ligand-activated transcription factors that play different roles in gene regulation and show both overlapping and specific tissue distribution patterns. ERβ, contrary to the oncogenic ERα, has been shown to act as an oncosuppressor in several instances. However, while the tumor-promoting actions of ERα are well-known, the exact role of ERβ in carcinogenesis and tumor progression is not yet fully understood. Indeed, to date, highly variable and even opposite effects have been ascribed to ERβ in cancer, including for example both proliferative and growth-inhibitory actions. Recently ERβ has been proposed as a potential target for cancer therapy, since it is expressed in a variety of breast cancers (BCs), including triple-negative ones (TNBCs). Because of the dependence of TNBCs on active cellular signaling, numerous studies have attempted to unravel the mechanism(s) behind ERβ-regulated gene expression programs but the scenario has not been fully revealed. We comprehensively reviewed the current state of knowledge concerning ERβ role in TNBC biology, focusing on the different signaling pathways and cellular processes regulated by this transcription factor, as they could be useful in identifying new diagnostic and therapeutic approaches for TNBC. MDPI 2020-06-05 /pmc/articles/PMC7353068/ /pubmed/32516978 http://dx.doi.org/10.3390/cancers12061477 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sellitto, Assunta D’Agostino, Ylenia Alexandrova, Elena Lamberti, Jessica Pecoraro, Giovanni Memoli, Domenico Rocco, Domenico Coviello, Elena Giurato, Giorgio Nassa, Giovanni Tarallo, Roberta Weisz, Alessandro Rizzo, Francesca Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer |
title | Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer |
title_full | Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer |
title_fullStr | Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer |
title_full_unstemmed | Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer |
title_short | Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer |
title_sort | insights into the role of estrogen receptor β in triple-negative breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353068/ https://www.ncbi.nlm.nih.gov/pubmed/32516978 http://dx.doi.org/10.3390/cancers12061477 |
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