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Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target

Anillin (ANLN), an actin-binding protein, reportedly plays a vital role in cell proliferation and migration, particularly in cytokinesis. Although there have been findings pointing to a contribution of ANLN to the development of cancer, the association of ANLN to cancer remains not fully understood....

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Detalles Bibliográficos
Autores principales: Tuan, Nguyen Minh, Lee, Chang Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353083/
https://www.ncbi.nlm.nih.gov/pubmed/32560530
http://dx.doi.org/10.3390/cancers12061600
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author Tuan, Nguyen Minh
Lee, Chang Hoon
author_facet Tuan, Nguyen Minh
Lee, Chang Hoon
author_sort Tuan, Nguyen Minh
collection PubMed
description Anillin (ANLN), an actin-binding protein, reportedly plays a vital role in cell proliferation and migration, particularly in cytokinesis. Although there have been findings pointing to a contribution of ANLN to the development of cancer, the association of ANLN to cancer remains not fully understood. Here, we gather evidence to determine the applicability of ANLN as a prognostic tool for some types of cancer, and the impact that ANLN has on the hallmarks of cancer. We searched academic repositories including PubMed and Google Scholar to find and review studies related to cancer and ANLN. The conclusion is that ANLN could be a potent target for cancer treatment, but the roles ANLN, other than in cytokinesis and its influence on tumour microenvironment remodeling in cancer development, must be further elucidated, and specific ANLN inhibitors should be found.
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spelling pubmed-73530832020-07-15 Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target Tuan, Nguyen Minh Lee, Chang Hoon Cancers (Basel) Review Anillin (ANLN), an actin-binding protein, reportedly plays a vital role in cell proliferation and migration, particularly in cytokinesis. Although there have been findings pointing to a contribution of ANLN to the development of cancer, the association of ANLN to cancer remains not fully understood. Here, we gather evidence to determine the applicability of ANLN as a prognostic tool for some types of cancer, and the impact that ANLN has on the hallmarks of cancer. We searched academic repositories including PubMed and Google Scholar to find and review studies related to cancer and ANLN. The conclusion is that ANLN could be a potent target for cancer treatment, but the roles ANLN, other than in cytokinesis and its influence on tumour microenvironment remodeling in cancer development, must be further elucidated, and specific ANLN inhibitors should be found. MDPI 2020-06-17 /pmc/articles/PMC7353083/ /pubmed/32560530 http://dx.doi.org/10.3390/cancers12061600 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tuan, Nguyen Minh
Lee, Chang Hoon
Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target
title Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target
title_full Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target
title_fullStr Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target
title_full_unstemmed Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target
title_short Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target
title_sort role of anillin in tumour: from a prognostic biomarker to a novel target
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353083/
https://www.ncbi.nlm.nih.gov/pubmed/32560530
http://dx.doi.org/10.3390/cancers12061600
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