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Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target
Anillin (ANLN), an actin-binding protein, reportedly plays a vital role in cell proliferation and migration, particularly in cytokinesis. Although there have been findings pointing to a contribution of ANLN to the development of cancer, the association of ANLN to cancer remains not fully understood....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353083/ https://www.ncbi.nlm.nih.gov/pubmed/32560530 http://dx.doi.org/10.3390/cancers12061600 |
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author | Tuan, Nguyen Minh Lee, Chang Hoon |
author_facet | Tuan, Nguyen Minh Lee, Chang Hoon |
author_sort | Tuan, Nguyen Minh |
collection | PubMed |
description | Anillin (ANLN), an actin-binding protein, reportedly plays a vital role in cell proliferation and migration, particularly in cytokinesis. Although there have been findings pointing to a contribution of ANLN to the development of cancer, the association of ANLN to cancer remains not fully understood. Here, we gather evidence to determine the applicability of ANLN as a prognostic tool for some types of cancer, and the impact that ANLN has on the hallmarks of cancer. We searched academic repositories including PubMed and Google Scholar to find and review studies related to cancer and ANLN. The conclusion is that ANLN could be a potent target for cancer treatment, but the roles ANLN, other than in cytokinesis and its influence on tumour microenvironment remodeling in cancer development, must be further elucidated, and specific ANLN inhibitors should be found. |
format | Online Article Text |
id | pubmed-7353083 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73530832020-07-15 Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target Tuan, Nguyen Minh Lee, Chang Hoon Cancers (Basel) Review Anillin (ANLN), an actin-binding protein, reportedly plays a vital role in cell proliferation and migration, particularly in cytokinesis. Although there have been findings pointing to a contribution of ANLN to the development of cancer, the association of ANLN to cancer remains not fully understood. Here, we gather evidence to determine the applicability of ANLN as a prognostic tool for some types of cancer, and the impact that ANLN has on the hallmarks of cancer. We searched academic repositories including PubMed and Google Scholar to find and review studies related to cancer and ANLN. The conclusion is that ANLN could be a potent target for cancer treatment, but the roles ANLN, other than in cytokinesis and its influence on tumour microenvironment remodeling in cancer development, must be further elucidated, and specific ANLN inhibitors should be found. MDPI 2020-06-17 /pmc/articles/PMC7353083/ /pubmed/32560530 http://dx.doi.org/10.3390/cancers12061600 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tuan, Nguyen Minh Lee, Chang Hoon Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target |
title | Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target |
title_full | Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target |
title_fullStr | Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target |
title_full_unstemmed | Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target |
title_short | Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target |
title_sort | role of anillin in tumour: from a prognostic biomarker to a novel target |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353083/ https://www.ncbi.nlm.nih.gov/pubmed/32560530 http://dx.doi.org/10.3390/cancers12061600 |
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