Cargando…

Mgr2 regulates mitochondrial preprotein import by associating with channel-forming Tim23 subunit

Mgr2, a newly identified subunit of the TIM23 complex, functions as a gatekeeper of presequence translocase and thereby maintains quality control of inner membrane preproteins sorting. However, precise recruitment of the Mgr2 subunit to the core channel and how it influences the assembly of the TIM2...

Descripción completa

Detalles Bibliográficos
Autores principales:	Matta, Srujan Kumar, Kumar, Abhishek, D’Silva, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2020
Materias:	Brief Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353164/ https://www.ncbi.nlm.nih.gov/pubmed/32186971 http://dx.doi.org/10.1091/mbc.E19-12-0677

Ejemplares similares

Dual interaction of scaffold protein Tim44 of mitochondrial import motor with channel-forming translocase subunit Tim23
por: Ting, See-Yeun, et al.
Publicado: (2017)

Deletion of Mgr2p Affects the Gating Behavior of the TIM23 Complex
por: Mirzalieva, Oygul, et al.
Publicado: (2019)

Cardiolipin mediates membrane and channel interactions of the mitochondrial TIM23 protein import complex receptor Tim50
por: Malhotra, Ketan, et al.
Publicado: (2017)

AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins
por: Yano, Masato, et al.
Publicado: (2003)

Amyloid β-peptides interfere with mitochondrial preprotein import competence by a coaggregation process
por: Cenini, Giovanna, et al.
Publicado: (2016)

Tom70 enhances mitochondrial preprotein import efficiency by binding to internal targeting sequences
por: Backes, Sandra, et al.
Publicado: (2018)

Mutations of the mitochondrial carrier translocase channel subunit TIM22 cause early-onset mitochondrial myopathy
por: Pacheu-Grau, David, et al.
Publicado: (2018)

Tim23–Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import
por: Tamura, Yasushi, et al.
Publicado: (2009)

Analysis of the Interactions of Preproteins with the Import Machinery over the Course of Protein Import into Chloroplasts
por: Kouranov, Andrei, et al.
Publicado: (1997)

The ABCs of MGR with DCJ
por: Adam, Zaky, et al.
Publicado: (2008)

Absence of mgrB Alleviates Negative Growth Effects of Colistin Resistance in Enterobacter cloacae
por: Wozniak, Jessie E., et al.
Publicado: (2020)

Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import
por: Denkert, Niels, et al.
Publicado: (2017)

Tim23, a Protein Import Component of the Mitochondrial Inner Membrane, Is Required for Normal Activity of the Multiple Conductance Channel, MCC
por: Lohret, Timothy A., et al.
Publicado: (1997)

Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes
por: Gebert, Michael, et al.
Publicado: (2012)

Presequence and mature part of preproteins strongly influence the dependence of mitochondrial protein import on heat shock protein 70 in the matrix
Publicado: (1993)

tRNA import across the mitochondrial inner membrane in T. brucei requires TIM subunits but is independent of protein import
por: Shikha, Shikha, et al.
Publicado: (2020)

Multiple variants of the human presequence translocase motor subunit Magmas govern the mitochondrial import
por: Waingankar, Tejashree Pradip, et al.
Publicado: (2021)

The journey of preproteins across the chloroplast membrane systems
por: Ballabani, Gent, et al.
Publicado: (2023)

A disulfide bond in the TIM23 complex is crucial for voltage gating and mitochondrial protein import
por: Ramesh, Ajay, et al.
Publicado: (2016)

NOX4–TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming
por: Pandey, Jyotsana, et al.
Publicado: (2023)

Biogenesis of the preprotein translocase of the outer mitochondrial membrane: protein kinase A phosphorylates the precursor of Tom40 and impairs its import
por: Rao, Sanjana, et al.
Publicado: (2012)

A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins
Publicado: (1993)

Role of Tim17 in coupling the import motor to the translocation channel of the mitochondrial presequence translocase
por: Demishtein-Zohary, Keren, et al.
Publicado: (2017)

Towards a molecular mechanism underlying mitochondrial protein import through the TOM and TIM23 complexes
por: Ford, Holly C, et al.
Publicado: (2022)

Loss of Endothelial Barrier in Marfan Mice (mgR/mgR) Results in Severe Inflammation after Adenoviral Gene Therapy
por: Seppelt, Philipp Christian, et al.
Publicado: (2016)

The role of GTP binding and hydrolysis at the atToc159 preprotein receptor during protein import into chloroplasts
por: Wang, Fei, et al.
Publicado: (2008)

Protein folding causes an arrest of preprotein translocation into mitochondria in vivo
Publicado: (1991)

Dimeric SecA Couples the Preprotein Translocation in an Asymmetric Manner
por: Tang, Ying, et al.
Publicado: (2011)

Structure of the SecY Complex Unlocked by a Preprotein Mimic
por: Hizlan, Dilem, et al.
Publicado: (2012)

Two Intermembrane Space Tim Complexes Interact with Different Domains of Tim23p during Its Import into Mitochondria
por: Davis, Alison J., et al.
Publicado: (2000)

A mutagenesis analysis of Tim50, the major receptor of the TIM23 complex, identifies regions that affect its interaction with Tim23
por: Dayan, Dana, et al.
Publicado: (2019)

In vitro uptake and processing of prezein and other maize preproteins by maize membranes
Publicado: (1981)

The preprotein translocase YidC controls respiratory metabolism in Mycobacterium tuberculosis
por: Thakur, Preeti, et al.
Publicado: (2016)

Preprotein mature domains contain translocase targeting signals that are essential for secretion
por: Chatzi, Katerina E., et al.
Publicado: (2017)

Two conformations of the Tom20 preprotein receptor in the TOM holo complex
por: Ornelas, Pamela, et al.
Publicado: (2023)

TIM23-mediated insertion of transmembrane α-helices into the mitochondrial inner membrane
por: Botelho, Salomé Calado, et al.
Publicado: (2011)

MgrB Inactivation Confers Trimethoprim Resistance in Escherichia coli
por: Shi, Hongmei, et al.
Publicado: (2021)

Single-Channel Properties of the ROMK-Pore-Forming Subunit of the Mitochondrial ATP-Sensitive Potassium Channel
por: Laskowski, Michał, et al.
Publicado: (2019)

IL‐6 Regulates Extracellular Matrix Remodeling Associated With Aortic Dilation in a Fibrillin‐1 Hypomorphic mgR/mgR Mouse Model of Severe Marfan Syndrome
por: Ju, Xiaoxi, et al.
Publicado: (2014)

Motor recruitment to the TIM23 channel’s lateral gate restricts polypeptide release into the inner membrane
por: Schendzielorz, Alexander Benjamin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_faohsvrh96ve09n5cmclrimgs0