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Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric Cancer

We aimed to investigate the impact of muscle atrophy and the neutrophil-to-lymphocyte ratio (NLR), a sub-clinical biomarker of inflammation and nutrition, on the prognosis of patients with unresectable advanced gastric cancer. We retrospectively enrolled 109 patients with stage IV gastric cancer (me...

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Autores principales: Shigeto, Kota, Kawaguchi, Takumi, Koya, Shunji, Hirota, Keisuke, Tanaka, Toshimitsu, Nagasu, Sachiko, Fukahori, Masaru, Ushijima, Tomoyuki, Matsuse, Hiroo, Miwa, Keisuke, Nagafuji, Koji, Torimura, Takuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353220/
https://www.ncbi.nlm.nih.gov/pubmed/32599747
http://dx.doi.org/10.3390/nu12061884
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author Shigeto, Kota
Kawaguchi, Takumi
Koya, Shunji
Hirota, Keisuke
Tanaka, Toshimitsu
Nagasu, Sachiko
Fukahori, Masaru
Ushijima, Tomoyuki
Matsuse, Hiroo
Miwa, Keisuke
Nagafuji, Koji
Torimura, Takuji
author_facet Shigeto, Kota
Kawaguchi, Takumi
Koya, Shunji
Hirota, Keisuke
Tanaka, Toshimitsu
Nagasu, Sachiko
Fukahori, Masaru
Ushijima, Tomoyuki
Matsuse, Hiroo
Miwa, Keisuke
Nagafuji, Koji
Torimura, Takuji
author_sort Shigeto, Kota
collection PubMed
description We aimed to investigate the impact of muscle atrophy and the neutrophil-to-lymphocyte ratio (NLR), a sub-clinical biomarker of inflammation and nutrition, on the prognosis of patients with unresectable advanced gastric cancer. We retrospectively enrolled 109 patients with stage IV gastric cancer (median age 69 years; female/male 22%/78%; median observational period 261 days). Independent factors and profiles for overall survival (OS) were determined by Cox regression analysis and decision-tree analysis, respectively. OS was calculated using the Kaplan–Meier method. The prevalence of muscle atrophy was 82.6% and the median NLR was 3.15. In Cox regression analysis, none of factors were identified as an independent factor for survival. The decision-tree analysis revealed that the most favorable prognostic profile was non-muscle atrophy (OS rate 36.8%). The most unfavorable prognostic profile was the combination of muscle atrophy and high NLR (OS rate 19.6%). The OS rate was significantly lower in patients with muscle atrophy and high NLR than in patients with non-muscle atrophy (1-year survival rate 28.5% vs. 54.7%; log-rank test p = 0.0014). In conclusion, “muscle atrophy and high NLR” was a prognostic profile for patients with stage IV gastric cancer. Thus, the assessment of muscle mass, subclinical inflammation, and malnutrition may be important for the management of patients with stage IV gastric cancer.
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spelling pubmed-73532202020-07-15 Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric Cancer Shigeto, Kota Kawaguchi, Takumi Koya, Shunji Hirota, Keisuke Tanaka, Toshimitsu Nagasu, Sachiko Fukahori, Masaru Ushijima, Tomoyuki Matsuse, Hiroo Miwa, Keisuke Nagafuji, Koji Torimura, Takuji Nutrients Article We aimed to investigate the impact of muscle atrophy and the neutrophil-to-lymphocyte ratio (NLR), a sub-clinical biomarker of inflammation and nutrition, on the prognosis of patients with unresectable advanced gastric cancer. We retrospectively enrolled 109 patients with stage IV gastric cancer (median age 69 years; female/male 22%/78%; median observational period 261 days). Independent factors and profiles for overall survival (OS) were determined by Cox regression analysis and decision-tree analysis, respectively. OS was calculated using the Kaplan–Meier method. The prevalence of muscle atrophy was 82.6% and the median NLR was 3.15. In Cox regression analysis, none of factors were identified as an independent factor for survival. The decision-tree analysis revealed that the most favorable prognostic profile was non-muscle atrophy (OS rate 36.8%). The most unfavorable prognostic profile was the combination of muscle atrophy and high NLR (OS rate 19.6%). The OS rate was significantly lower in patients with muscle atrophy and high NLR than in patients with non-muscle atrophy (1-year survival rate 28.5% vs. 54.7%; log-rank test p = 0.0014). In conclusion, “muscle atrophy and high NLR” was a prognostic profile for patients with stage IV gastric cancer. Thus, the assessment of muscle mass, subclinical inflammation, and malnutrition may be important for the management of patients with stage IV gastric cancer. MDPI 2020-06-24 /pmc/articles/PMC7353220/ /pubmed/32599747 http://dx.doi.org/10.3390/nu12061884 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shigeto, Kota
Kawaguchi, Takumi
Koya, Shunji
Hirota, Keisuke
Tanaka, Toshimitsu
Nagasu, Sachiko
Fukahori, Masaru
Ushijima, Tomoyuki
Matsuse, Hiroo
Miwa, Keisuke
Nagafuji, Koji
Torimura, Takuji
Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric Cancer
title Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric Cancer
title_full Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric Cancer
title_fullStr Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric Cancer
title_full_unstemmed Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric Cancer
title_short Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric Cancer
title_sort profiles combining muscle atrophy and neutrophil-to-lymphocyte ratio are associated with prognosis of patients with stage iv gastric cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353220/
https://www.ncbi.nlm.nih.gov/pubmed/32599747
http://dx.doi.org/10.3390/nu12061884
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