Cargando…

Effects of 3-Month Astaxanthin Supplementation on Cardiac Function in Heart Failure Patients with Left Ventricular Systolic Dysfunction-A Pilot Study

Astaxanthin has strong antioxidant properties. We conducted a prospective pilot study on heart failure (HF) patients with left ventricular (LV) systolic dysfunction to investigate improvements in cardiac function and exercise tolerance in relation to suppression of oxidative stress by 3-month astaxa...

Descripción completa

Detalles Bibliográficos
Autores principales: Kato, Takao, Kasai, Takatoshi, Sato, Akihiro, Ishiwata, Sayaki, Yatsu, Shoichiro, Matsumoto, Hiroki, Shitara, Jun, Murata, Azusa, Shimizu, Megumi, Suda, Shoko, Hiki, Masaru, Naito, Ryo, Daida, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353230/
https://www.ncbi.nlm.nih.gov/pubmed/32604721
http://dx.doi.org/10.3390/nu12061896
_version_ 1783557827459022848
author Kato, Takao
Kasai, Takatoshi
Sato, Akihiro
Ishiwata, Sayaki
Yatsu, Shoichiro
Matsumoto, Hiroki
Shitara, Jun
Murata, Azusa
Shimizu, Megumi
Suda, Shoko
Hiki, Masaru
Naito, Ryo
Daida, Hiroyuki
author_facet Kato, Takao
Kasai, Takatoshi
Sato, Akihiro
Ishiwata, Sayaki
Yatsu, Shoichiro
Matsumoto, Hiroki
Shitara, Jun
Murata, Azusa
Shimizu, Megumi
Suda, Shoko
Hiki, Masaru
Naito, Ryo
Daida, Hiroyuki
author_sort Kato, Takao
collection PubMed
description Astaxanthin has strong antioxidant properties. We conducted a prospective pilot study on heart failure (HF) patients with left ventricular (LV) systolic dysfunction to investigate improvements in cardiac function and exercise tolerance in relation to suppression of oxidative stress by 3-month astaxanthin supplementation. Oxidative stress markers—serum Diacron reactive oxygen metabolite (dROM), biological antioxidant potential (BAP), and urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) concentrations, LV ejection fraction (LVEF), and 6-min walk distance (6MWD) were assessed before and after 3-month astaxanthin supplementation. Finally, the data of 16 HF patients were analyzed. Following 3-month astaxanthin supplementation, dROM level decreased from 385.6 ± 82.6 U.CARR to 346.5 ± 56.9 U.CARR (p = 0.041) despite no changes in BAP and urinary 8-OHdG levels. LVEF increased from 34.1 ± 8.6% to 38.0 ± 10.0% (p = 0.031) and 6MWD increased from 393.4 ± 95.9 m to 432.8 ± 93.3 m (p = 0.023). Significant relationships were observed between percent changes in dROM level and those in LVEF. In this study, following 3-month astaxanthin supplementation, suppressed oxidative stress and improved cardiac contractility and exercise tolerance were observed in HF patients with LV systolic dysfunction. Correlation between suppression of oxidative stress and improvement of cardiac contractility suggests that suppression of oxidative stress by astaxanthin supplementation had therapeutic potential to improve cardiac functioning.
format Online
Article
Text
id pubmed-7353230
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-73532302020-07-15 Effects of 3-Month Astaxanthin Supplementation on Cardiac Function in Heart Failure Patients with Left Ventricular Systolic Dysfunction-A Pilot Study Kato, Takao Kasai, Takatoshi Sato, Akihiro Ishiwata, Sayaki Yatsu, Shoichiro Matsumoto, Hiroki Shitara, Jun Murata, Azusa Shimizu, Megumi Suda, Shoko Hiki, Masaru Naito, Ryo Daida, Hiroyuki Nutrients Article Astaxanthin has strong antioxidant properties. We conducted a prospective pilot study on heart failure (HF) patients with left ventricular (LV) systolic dysfunction to investigate improvements in cardiac function and exercise tolerance in relation to suppression of oxidative stress by 3-month astaxanthin supplementation. Oxidative stress markers—serum Diacron reactive oxygen metabolite (dROM), biological antioxidant potential (BAP), and urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) concentrations, LV ejection fraction (LVEF), and 6-min walk distance (6MWD) were assessed before and after 3-month astaxanthin supplementation. Finally, the data of 16 HF patients were analyzed. Following 3-month astaxanthin supplementation, dROM level decreased from 385.6 ± 82.6 U.CARR to 346.5 ± 56.9 U.CARR (p = 0.041) despite no changes in BAP and urinary 8-OHdG levels. LVEF increased from 34.1 ± 8.6% to 38.0 ± 10.0% (p = 0.031) and 6MWD increased from 393.4 ± 95.9 m to 432.8 ± 93.3 m (p = 0.023). Significant relationships were observed between percent changes in dROM level and those in LVEF. In this study, following 3-month astaxanthin supplementation, suppressed oxidative stress and improved cardiac contractility and exercise tolerance were observed in HF patients with LV systolic dysfunction. Correlation between suppression of oxidative stress and improvement of cardiac contractility suggests that suppression of oxidative stress by astaxanthin supplementation had therapeutic potential to improve cardiac functioning. MDPI 2020-06-26 /pmc/articles/PMC7353230/ /pubmed/32604721 http://dx.doi.org/10.3390/nu12061896 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kato, Takao
Kasai, Takatoshi
Sato, Akihiro
Ishiwata, Sayaki
Yatsu, Shoichiro
Matsumoto, Hiroki
Shitara, Jun
Murata, Azusa
Shimizu, Megumi
Suda, Shoko
Hiki, Masaru
Naito, Ryo
Daida, Hiroyuki
Effects of 3-Month Astaxanthin Supplementation on Cardiac Function in Heart Failure Patients with Left Ventricular Systolic Dysfunction-A Pilot Study
title Effects of 3-Month Astaxanthin Supplementation on Cardiac Function in Heart Failure Patients with Left Ventricular Systolic Dysfunction-A Pilot Study
title_full Effects of 3-Month Astaxanthin Supplementation on Cardiac Function in Heart Failure Patients with Left Ventricular Systolic Dysfunction-A Pilot Study
title_fullStr Effects of 3-Month Astaxanthin Supplementation on Cardiac Function in Heart Failure Patients with Left Ventricular Systolic Dysfunction-A Pilot Study
title_full_unstemmed Effects of 3-Month Astaxanthin Supplementation on Cardiac Function in Heart Failure Patients with Left Ventricular Systolic Dysfunction-A Pilot Study
title_short Effects of 3-Month Astaxanthin Supplementation on Cardiac Function in Heart Failure Patients with Left Ventricular Systolic Dysfunction-A Pilot Study
title_sort effects of 3-month astaxanthin supplementation on cardiac function in heart failure patients with left ventricular systolic dysfunction-a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353230/
https://www.ncbi.nlm.nih.gov/pubmed/32604721
http://dx.doi.org/10.3390/nu12061896
work_keys_str_mv AT katotakao effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy
AT kasaitakatoshi effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy
AT satoakihiro effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy
AT ishiwatasayaki effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy
AT yatsushoichiro effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy
AT matsumotohiroki effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy
AT shitarajun effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy
AT murataazusa effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy
AT shimizumegumi effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy
AT sudashoko effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy
AT hikimasaru effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy
AT naitoryo effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy
AT daidahiroyuki effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy