Cargando…
Effects of 3-Month Astaxanthin Supplementation on Cardiac Function in Heart Failure Patients with Left Ventricular Systolic Dysfunction-A Pilot Study
Astaxanthin has strong antioxidant properties. We conducted a prospective pilot study on heart failure (HF) patients with left ventricular (LV) systolic dysfunction to investigate improvements in cardiac function and exercise tolerance in relation to suppression of oxidative stress by 3-month astaxa...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353230/ https://www.ncbi.nlm.nih.gov/pubmed/32604721 http://dx.doi.org/10.3390/nu12061896 |
_version_ | 1783557827459022848 |
---|---|
author | Kato, Takao Kasai, Takatoshi Sato, Akihiro Ishiwata, Sayaki Yatsu, Shoichiro Matsumoto, Hiroki Shitara, Jun Murata, Azusa Shimizu, Megumi Suda, Shoko Hiki, Masaru Naito, Ryo Daida, Hiroyuki |
author_facet | Kato, Takao Kasai, Takatoshi Sato, Akihiro Ishiwata, Sayaki Yatsu, Shoichiro Matsumoto, Hiroki Shitara, Jun Murata, Azusa Shimizu, Megumi Suda, Shoko Hiki, Masaru Naito, Ryo Daida, Hiroyuki |
author_sort | Kato, Takao |
collection | PubMed |
description | Astaxanthin has strong antioxidant properties. We conducted a prospective pilot study on heart failure (HF) patients with left ventricular (LV) systolic dysfunction to investigate improvements in cardiac function and exercise tolerance in relation to suppression of oxidative stress by 3-month astaxanthin supplementation. Oxidative stress markers—serum Diacron reactive oxygen metabolite (dROM), biological antioxidant potential (BAP), and urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) concentrations, LV ejection fraction (LVEF), and 6-min walk distance (6MWD) were assessed before and after 3-month astaxanthin supplementation. Finally, the data of 16 HF patients were analyzed. Following 3-month astaxanthin supplementation, dROM level decreased from 385.6 ± 82.6 U.CARR to 346.5 ± 56.9 U.CARR (p = 0.041) despite no changes in BAP and urinary 8-OHdG levels. LVEF increased from 34.1 ± 8.6% to 38.0 ± 10.0% (p = 0.031) and 6MWD increased from 393.4 ± 95.9 m to 432.8 ± 93.3 m (p = 0.023). Significant relationships were observed between percent changes in dROM level and those in LVEF. In this study, following 3-month astaxanthin supplementation, suppressed oxidative stress and improved cardiac contractility and exercise tolerance were observed in HF patients with LV systolic dysfunction. Correlation between suppression of oxidative stress and improvement of cardiac contractility suggests that suppression of oxidative stress by astaxanthin supplementation had therapeutic potential to improve cardiac functioning. |
format | Online Article Text |
id | pubmed-7353230 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73532302020-07-15 Effects of 3-Month Astaxanthin Supplementation on Cardiac Function in Heart Failure Patients with Left Ventricular Systolic Dysfunction-A Pilot Study Kato, Takao Kasai, Takatoshi Sato, Akihiro Ishiwata, Sayaki Yatsu, Shoichiro Matsumoto, Hiroki Shitara, Jun Murata, Azusa Shimizu, Megumi Suda, Shoko Hiki, Masaru Naito, Ryo Daida, Hiroyuki Nutrients Article Astaxanthin has strong antioxidant properties. We conducted a prospective pilot study on heart failure (HF) patients with left ventricular (LV) systolic dysfunction to investigate improvements in cardiac function and exercise tolerance in relation to suppression of oxidative stress by 3-month astaxanthin supplementation. Oxidative stress markers—serum Diacron reactive oxygen metabolite (dROM), biological antioxidant potential (BAP), and urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) concentrations, LV ejection fraction (LVEF), and 6-min walk distance (6MWD) were assessed before and after 3-month astaxanthin supplementation. Finally, the data of 16 HF patients were analyzed. Following 3-month astaxanthin supplementation, dROM level decreased from 385.6 ± 82.6 U.CARR to 346.5 ± 56.9 U.CARR (p = 0.041) despite no changes in BAP and urinary 8-OHdG levels. LVEF increased from 34.1 ± 8.6% to 38.0 ± 10.0% (p = 0.031) and 6MWD increased from 393.4 ± 95.9 m to 432.8 ± 93.3 m (p = 0.023). Significant relationships were observed between percent changes in dROM level and those in LVEF. In this study, following 3-month astaxanthin supplementation, suppressed oxidative stress and improved cardiac contractility and exercise tolerance were observed in HF patients with LV systolic dysfunction. Correlation between suppression of oxidative stress and improvement of cardiac contractility suggests that suppression of oxidative stress by astaxanthin supplementation had therapeutic potential to improve cardiac functioning. MDPI 2020-06-26 /pmc/articles/PMC7353230/ /pubmed/32604721 http://dx.doi.org/10.3390/nu12061896 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kato, Takao Kasai, Takatoshi Sato, Akihiro Ishiwata, Sayaki Yatsu, Shoichiro Matsumoto, Hiroki Shitara, Jun Murata, Azusa Shimizu, Megumi Suda, Shoko Hiki, Masaru Naito, Ryo Daida, Hiroyuki Effects of 3-Month Astaxanthin Supplementation on Cardiac Function in Heart Failure Patients with Left Ventricular Systolic Dysfunction-A Pilot Study |
title | Effects of 3-Month Astaxanthin Supplementation on Cardiac Function in Heart Failure Patients with Left Ventricular Systolic Dysfunction-A Pilot Study |
title_full | Effects of 3-Month Astaxanthin Supplementation on Cardiac Function in Heart Failure Patients with Left Ventricular Systolic Dysfunction-A Pilot Study |
title_fullStr | Effects of 3-Month Astaxanthin Supplementation on Cardiac Function in Heart Failure Patients with Left Ventricular Systolic Dysfunction-A Pilot Study |
title_full_unstemmed | Effects of 3-Month Astaxanthin Supplementation on Cardiac Function in Heart Failure Patients with Left Ventricular Systolic Dysfunction-A Pilot Study |
title_short | Effects of 3-Month Astaxanthin Supplementation on Cardiac Function in Heart Failure Patients with Left Ventricular Systolic Dysfunction-A Pilot Study |
title_sort | effects of 3-month astaxanthin supplementation on cardiac function in heart failure patients with left ventricular systolic dysfunction-a pilot study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353230/ https://www.ncbi.nlm.nih.gov/pubmed/32604721 http://dx.doi.org/10.3390/nu12061896 |
work_keys_str_mv | AT katotakao effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy AT kasaitakatoshi effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy AT satoakihiro effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy AT ishiwatasayaki effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy AT yatsushoichiro effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy AT matsumotohiroki effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy AT shitarajun effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy AT murataazusa effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy AT shimizumegumi effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy AT sudashoko effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy AT hikimasaru effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy AT naitoryo effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy AT daidahiroyuki effectsof3monthastaxanthinsupplementationoncardiacfunctioninheartfailurepatientswithleftventricularsystolicdysfunctionapilotstudy |