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Characteristic Analysis of Trigonelline Contained in Raphanus sativus Cv. Sakurajima Daikon and Results from the First Trial Examining Its Vasodilator Properties in Humans

Vascular disease poses a major public health problem worldwide. Trigonelline isolated from Raphanus sativus cv. Sakurajima Daikon (Sakurajima radish) induces nitric oxide production from vascular endothelial cells and enhances vascular function. Here, we investigated the characteristics of trigonell...

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Autores principales: Sasaki, Maho, Nonoshita, Yuri, Kajiya, Takashi, Atsuchi, Nobuhiko, Kido, Megumi, Chu, Djong-Chi, Juneja, Lekh Raj, Minami, Yuji, Kajiya, Katsuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353243/
https://www.ncbi.nlm.nih.gov/pubmed/32585930
http://dx.doi.org/10.3390/nu12061872
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author Sasaki, Maho
Nonoshita, Yuri
Kajiya, Takashi
Atsuchi, Nobuhiko
Kido, Megumi
Chu, Djong-Chi
Juneja, Lekh Raj
Minami, Yuji
Kajiya, Katsuko
author_facet Sasaki, Maho
Nonoshita, Yuri
Kajiya, Takashi
Atsuchi, Nobuhiko
Kido, Megumi
Chu, Djong-Chi
Juneja, Lekh Raj
Minami, Yuji
Kajiya, Katsuko
author_sort Sasaki, Maho
collection PubMed
description Vascular disease poses a major public health problem worldwide. Trigonelline isolated from Raphanus sativus cv. Sakurajima Daikon (Sakurajima radish) induces nitric oxide production from vascular endothelial cells and enhances vascular function. Here, we investigated the characteristics of trigonelline and its effects on endothelial function after consumption of Sakurajima radish by humans. Our results show that Sakurajima radish contains approximately 60 times more trigonelline than other radishes and squashes. Additionally, no significant differences were observed between varieties of Sakurajima radish, suggesting that any type of Sakurajima radish can be ingested for trigonelline supplementation. The effects of cooking and processing Sakurajima radish were also evaluated, as were the effects of freezing, and changes in osmotic pressure and pH. A first-in-human trial using Sakurajima radish showed that ingestion of 170 g/day of Sakurajima radish for ten days increased blood trigonelline concentrations and significantly improved flow-mediated dilation, which is a measure of vascular endothelial function. Overall, our findings suggest that the trigonelline contained in Sakurajima radish may contribute to improved human vascular endothelial function. Hence, Sakurajima radish may enhance vascular endothelial function as a functional food.
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spelling pubmed-73532432020-07-15 Characteristic Analysis of Trigonelline Contained in Raphanus sativus Cv. Sakurajima Daikon and Results from the First Trial Examining Its Vasodilator Properties in Humans Sasaki, Maho Nonoshita, Yuri Kajiya, Takashi Atsuchi, Nobuhiko Kido, Megumi Chu, Djong-Chi Juneja, Lekh Raj Minami, Yuji Kajiya, Katsuko Nutrients Article Vascular disease poses a major public health problem worldwide. Trigonelline isolated from Raphanus sativus cv. Sakurajima Daikon (Sakurajima radish) induces nitric oxide production from vascular endothelial cells and enhances vascular function. Here, we investigated the characteristics of trigonelline and its effects on endothelial function after consumption of Sakurajima radish by humans. Our results show that Sakurajima radish contains approximately 60 times more trigonelline than other radishes and squashes. Additionally, no significant differences were observed between varieties of Sakurajima radish, suggesting that any type of Sakurajima radish can be ingested for trigonelline supplementation. The effects of cooking and processing Sakurajima radish were also evaluated, as were the effects of freezing, and changes in osmotic pressure and pH. A first-in-human trial using Sakurajima radish showed that ingestion of 170 g/day of Sakurajima radish for ten days increased blood trigonelline concentrations and significantly improved flow-mediated dilation, which is a measure of vascular endothelial function. Overall, our findings suggest that the trigonelline contained in Sakurajima radish may contribute to improved human vascular endothelial function. Hence, Sakurajima radish may enhance vascular endothelial function as a functional food. MDPI 2020-06-23 /pmc/articles/PMC7353243/ /pubmed/32585930 http://dx.doi.org/10.3390/nu12061872 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sasaki, Maho
Nonoshita, Yuri
Kajiya, Takashi
Atsuchi, Nobuhiko
Kido, Megumi
Chu, Djong-Chi
Juneja, Lekh Raj
Minami, Yuji
Kajiya, Katsuko
Characteristic Analysis of Trigonelline Contained in Raphanus sativus Cv. Sakurajima Daikon and Results from the First Trial Examining Its Vasodilator Properties in Humans
title Characteristic Analysis of Trigonelline Contained in Raphanus sativus Cv. Sakurajima Daikon and Results from the First Trial Examining Its Vasodilator Properties in Humans
title_full Characteristic Analysis of Trigonelline Contained in Raphanus sativus Cv. Sakurajima Daikon and Results from the First Trial Examining Its Vasodilator Properties in Humans
title_fullStr Characteristic Analysis of Trigonelline Contained in Raphanus sativus Cv. Sakurajima Daikon and Results from the First Trial Examining Its Vasodilator Properties in Humans
title_full_unstemmed Characteristic Analysis of Trigonelline Contained in Raphanus sativus Cv. Sakurajima Daikon and Results from the First Trial Examining Its Vasodilator Properties in Humans
title_short Characteristic Analysis of Trigonelline Contained in Raphanus sativus Cv. Sakurajima Daikon and Results from the First Trial Examining Its Vasodilator Properties in Humans
title_sort characteristic analysis of trigonelline contained in raphanus sativus cv. sakurajima daikon and results from the first trial examining its vasodilator properties in humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353243/
https://www.ncbi.nlm.nih.gov/pubmed/32585930
http://dx.doi.org/10.3390/nu12061872
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