Cargando…

Amino Acids and Developmental Origins of Hypertension

During pregnancy, amino acids are important biomolecules that play essential roles in fetal growth and development. Imbalanced amino acid intake during gestation may produce long-term morphological or functional changes in offspring, for example, developmental programming that increases the risk of...

Descripción completa

Detalles Bibliográficos
Autores principales: Hsu, Chien-Ning, Tain, You-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353289/
https://www.ncbi.nlm.nih.gov/pubmed/32545526
http://dx.doi.org/10.3390/nu12061763
_version_ 1783557841595924480
author Hsu, Chien-Ning
Tain, You-Lin
author_facet Hsu, Chien-Ning
Tain, You-Lin
author_sort Hsu, Chien-Ning
collection PubMed
description During pregnancy, amino acids are important biomolecules that play essential roles in fetal growth and development. Imbalanced amino acid intake during gestation may produce long-term morphological or functional changes in offspring, for example, developmental programming that increases the risk of developing hypertension in later life. Conversely, supplementation with specific amino acids could reverse the programming processes in early life, which may counteract the rising epidemic of hypertension. This review provides an overview of the evidence supporting the importance of amino acids during pregnancy and fetal development, the impact of amino acids on blood pressure regulation, insight from animal models in which amino acids were used to prevent hypertension of developmental origin, and interactions between amino acids and the common mechanisms underlying development programming of hypertension. A better understanding of the pathophysiological roles of specific amino acids and their interactions in developmental programming of hypertension is essential so that pregnant mothers are able to benefit from accurate amino acid supplementation during pregnancy in order to prevent hypertension development in their children.
format Online
Article
Text
id pubmed-7353289
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-73532892020-07-15 Amino Acids and Developmental Origins of Hypertension Hsu, Chien-Ning Tain, You-Lin Nutrients Review During pregnancy, amino acids are important biomolecules that play essential roles in fetal growth and development. Imbalanced amino acid intake during gestation may produce long-term morphological or functional changes in offspring, for example, developmental programming that increases the risk of developing hypertension in later life. Conversely, supplementation with specific amino acids could reverse the programming processes in early life, which may counteract the rising epidemic of hypertension. This review provides an overview of the evidence supporting the importance of amino acids during pregnancy and fetal development, the impact of amino acids on blood pressure regulation, insight from animal models in which amino acids were used to prevent hypertension of developmental origin, and interactions between amino acids and the common mechanisms underlying development programming of hypertension. A better understanding of the pathophysiological roles of specific amino acids and their interactions in developmental programming of hypertension is essential so that pregnant mothers are able to benefit from accurate amino acid supplementation during pregnancy in order to prevent hypertension development in their children. MDPI 2020-06-12 /pmc/articles/PMC7353289/ /pubmed/32545526 http://dx.doi.org/10.3390/nu12061763 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hsu, Chien-Ning
Tain, You-Lin
Amino Acids and Developmental Origins of Hypertension
title Amino Acids and Developmental Origins of Hypertension
title_full Amino Acids and Developmental Origins of Hypertension
title_fullStr Amino Acids and Developmental Origins of Hypertension
title_full_unstemmed Amino Acids and Developmental Origins of Hypertension
title_short Amino Acids and Developmental Origins of Hypertension
title_sort amino acids and developmental origins of hypertension
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353289/
https://www.ncbi.nlm.nih.gov/pubmed/32545526
http://dx.doi.org/10.3390/nu12061763
work_keys_str_mv AT hsuchienning aminoacidsanddevelopmentaloriginsofhypertension
AT tainyoulin aminoacidsanddevelopmentaloriginsofhypertension