Cargando…

SNP rs6564851 in the BCO1 Gene Is Associated with Varying Provitamin a Plasma Concentrations but Not with Retinol Concentrations among Adolescents from Rural Ghana

In sub-Saharan Africa, vitamin A deficiency constitutes a severe health problem despite various supplementation and food fortification programs. Given that the intake of preformed vitamin A from animal products remains low in these countries, an efficient metabolization of plant-based provitamin A c...

Descripción completa

Detalles Bibliográficos
Autores principales: Graßmann, Sophie, Pivovarova-Ramich, Olga, Henze, Andrea, Raila, Jens, Ampem Amoako, Yaw, King Nyamekye, Richard, Bedu-Addo, George, Mockenhaupt, Frank P., Schulze, Matthias B., Danquah, Ina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353293/
https://www.ncbi.nlm.nih.gov/pubmed/32560166
http://dx.doi.org/10.3390/nu12061786
_version_ 1783557842542788608
author Graßmann, Sophie
Pivovarova-Ramich, Olga
Henze, Andrea
Raila, Jens
Ampem Amoako, Yaw
King Nyamekye, Richard
Bedu-Addo, George
Mockenhaupt, Frank P.
Schulze, Matthias B.
Danquah, Ina
author_facet Graßmann, Sophie
Pivovarova-Ramich, Olga
Henze, Andrea
Raila, Jens
Ampem Amoako, Yaw
King Nyamekye, Richard
Bedu-Addo, George
Mockenhaupt, Frank P.
Schulze, Matthias B.
Danquah, Ina
author_sort Graßmann, Sophie
collection PubMed
description In sub-Saharan Africa, vitamin A deficiency constitutes a severe health problem despite various supplementation and food fortification programs. Given that the intake of preformed vitamin A from animal products remains low in these countries, an efficient metabolization of plant-based provitamin A carotenoids is essential. Previously, adolescents in rural Ghana have shown high total plasma carotenoid concentrations, while 36% had a vitamin A deficiency (defined as plasma retinol < 0.7 µmol/L). Hence, the aim of this cross-sectional study was to identify the relationships between variants in the β-carotene 15,15’-oxygenase (BCO1) gene and plasma carotenoid concentrations among 189 15-year-old girls and boys in rural Ghana. BCO1 rs6564851, rs7500996, rs10048138 and PKD1L2 rs6420424, and rs8044334 were typed, and carotenoid concentrations were compared among the different genotypes. G allele carriers of rs6564851 (53%) showed higher plasma carotenoid concentrations than T allele carriers (median (interquartile range): 3.07 (2.17–4.02) vs. 2.59 (2.21–3.50) µmol/L, p-value = 0.0424). This was not explained by differences in socio-demographic or dietary factors. In contrast, no differences in plasma retinol concentrations were observed between these genotypes. Pending verification in independent populations, the low conversion efficiency of provitamin A carotenoids among rs6564851 G allele carriers may undermine existing fortification and supplementation programs to improve the vitamin A status in sub-Saharan Africa.
format Online
Article
Text
id pubmed-7353293
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-73532932020-07-15 SNP rs6564851 in the BCO1 Gene Is Associated with Varying Provitamin a Plasma Concentrations but Not with Retinol Concentrations among Adolescents from Rural Ghana Graßmann, Sophie Pivovarova-Ramich, Olga Henze, Andrea Raila, Jens Ampem Amoako, Yaw King Nyamekye, Richard Bedu-Addo, George Mockenhaupt, Frank P. Schulze, Matthias B. Danquah, Ina Nutrients Article In sub-Saharan Africa, vitamin A deficiency constitutes a severe health problem despite various supplementation and food fortification programs. Given that the intake of preformed vitamin A from animal products remains low in these countries, an efficient metabolization of plant-based provitamin A carotenoids is essential. Previously, adolescents in rural Ghana have shown high total plasma carotenoid concentrations, while 36% had a vitamin A deficiency (defined as plasma retinol < 0.7 µmol/L). Hence, the aim of this cross-sectional study was to identify the relationships between variants in the β-carotene 15,15’-oxygenase (BCO1) gene and plasma carotenoid concentrations among 189 15-year-old girls and boys in rural Ghana. BCO1 rs6564851, rs7500996, rs10048138 and PKD1L2 rs6420424, and rs8044334 were typed, and carotenoid concentrations were compared among the different genotypes. G allele carriers of rs6564851 (53%) showed higher plasma carotenoid concentrations than T allele carriers (median (interquartile range): 3.07 (2.17–4.02) vs. 2.59 (2.21–3.50) µmol/L, p-value = 0.0424). This was not explained by differences in socio-demographic or dietary factors. In contrast, no differences in plasma retinol concentrations were observed between these genotypes. Pending verification in independent populations, the low conversion efficiency of provitamin A carotenoids among rs6564851 G allele carriers may undermine existing fortification and supplementation programs to improve the vitamin A status in sub-Saharan Africa. MDPI 2020-06-16 /pmc/articles/PMC7353293/ /pubmed/32560166 http://dx.doi.org/10.3390/nu12061786 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Graßmann, Sophie
Pivovarova-Ramich, Olga
Henze, Andrea
Raila, Jens
Ampem Amoako, Yaw
King Nyamekye, Richard
Bedu-Addo, George
Mockenhaupt, Frank P.
Schulze, Matthias B.
Danquah, Ina
SNP rs6564851 in the BCO1 Gene Is Associated with Varying Provitamin a Plasma Concentrations but Not with Retinol Concentrations among Adolescents from Rural Ghana
title SNP rs6564851 in the BCO1 Gene Is Associated with Varying Provitamin a Plasma Concentrations but Not with Retinol Concentrations among Adolescents from Rural Ghana
title_full SNP rs6564851 in the BCO1 Gene Is Associated with Varying Provitamin a Plasma Concentrations but Not with Retinol Concentrations among Adolescents from Rural Ghana
title_fullStr SNP rs6564851 in the BCO1 Gene Is Associated with Varying Provitamin a Plasma Concentrations but Not with Retinol Concentrations among Adolescents from Rural Ghana
title_full_unstemmed SNP rs6564851 in the BCO1 Gene Is Associated with Varying Provitamin a Plasma Concentrations but Not with Retinol Concentrations among Adolescents from Rural Ghana
title_short SNP rs6564851 in the BCO1 Gene Is Associated with Varying Provitamin a Plasma Concentrations but Not with Retinol Concentrations among Adolescents from Rural Ghana
title_sort snp rs6564851 in the bco1 gene is associated with varying provitamin a plasma concentrations but not with retinol concentrations among adolescents from rural ghana
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353293/
https://www.ncbi.nlm.nih.gov/pubmed/32560166
http://dx.doi.org/10.3390/nu12061786
work_keys_str_mv AT graßmannsophie snprs6564851inthebco1geneisassociatedwithvaryingprovitaminaplasmaconcentrationsbutnotwithretinolconcentrationsamongadolescentsfromruralghana
AT pivovarovaramicholga snprs6564851inthebco1geneisassociatedwithvaryingprovitaminaplasmaconcentrationsbutnotwithretinolconcentrationsamongadolescentsfromruralghana
AT henzeandrea snprs6564851inthebco1geneisassociatedwithvaryingprovitaminaplasmaconcentrationsbutnotwithretinolconcentrationsamongadolescentsfromruralghana
AT railajens snprs6564851inthebco1geneisassociatedwithvaryingprovitaminaplasmaconcentrationsbutnotwithretinolconcentrationsamongadolescentsfromruralghana
AT ampemamoakoyaw snprs6564851inthebco1geneisassociatedwithvaryingprovitaminaplasmaconcentrationsbutnotwithretinolconcentrationsamongadolescentsfromruralghana
AT kingnyamekyerichard snprs6564851inthebco1geneisassociatedwithvaryingprovitaminaplasmaconcentrationsbutnotwithretinolconcentrationsamongadolescentsfromruralghana
AT beduaddogeorge snprs6564851inthebco1geneisassociatedwithvaryingprovitaminaplasmaconcentrationsbutnotwithretinolconcentrationsamongadolescentsfromruralghana
AT mockenhauptfrankp snprs6564851inthebco1geneisassociatedwithvaryingprovitaminaplasmaconcentrationsbutnotwithretinolconcentrationsamongadolescentsfromruralghana
AT schulzematthiasb snprs6564851inthebco1geneisassociatedwithvaryingprovitaminaplasmaconcentrationsbutnotwithretinolconcentrationsamongadolescentsfromruralghana
AT danquahina snprs6564851inthebco1geneisassociatedwithvaryingprovitaminaplasmaconcentrationsbutnotwithretinolconcentrationsamongadolescentsfromruralghana