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Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction

Pelvic organ prolapse (POP) is a hidden women’s health disorder that impacts 1 in 4 women across all age groups. Surgical intervention has been the only treatment option, often involving non-degradable meshes, with variable results. However, recent reports have highlighted the adverse effects of mes...

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Autores principales: Paul, Kallyanashis, Darzi, Saeedeh, Werkmeister, Jerome A., Gargett, Caroline E., Mukherjee, Shayanti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353440/
https://www.ncbi.nlm.nih.gov/pubmed/32517067
http://dx.doi.org/10.3390/nano10061120
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author Paul, Kallyanashis
Darzi, Saeedeh
Werkmeister, Jerome A.
Gargett, Caroline E.
Mukherjee, Shayanti
author_facet Paul, Kallyanashis
Darzi, Saeedeh
Werkmeister, Jerome A.
Gargett, Caroline E.
Mukherjee, Shayanti
author_sort Paul, Kallyanashis
collection PubMed
description Pelvic organ prolapse (POP) is a hidden women’s health disorder that impacts 1 in 4 women across all age groups. Surgical intervention has been the only treatment option, often involving non-degradable meshes, with variable results. However, recent reports have highlighted the adverse effects of meshes in the long term, which involve unacceptable rates of erosion, chronic infection and severe pain related to mesh shrinkage. Therefore, there is an urgent unmet need to fabricate of new class of biocompatible meshes for the treatment of POP. This review focuses on the causes for the downfall of commercial meshes, and discusses the use of emerging technologies such as electrospinning and 3D printing to design new meshes. Furthermore, we discuss the impact and advantage of nano-/microstructured alternative meshes over commercial meshes with respect to their tissue integration performance. Considering the key challenges of current meshes, we discuss the potential of cell-based tissue engineering strategies to augment the new class of meshes to improve biocompatibility and immunomodulation. Finally, this review highlights the future direction in designing the new class of mesh to overcome the hurdles of foreign body rejection faced by the traditional meshes, in order to have safe and effective treatment for women in the long term.
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spelling pubmed-73534402020-07-15 Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction Paul, Kallyanashis Darzi, Saeedeh Werkmeister, Jerome A. Gargett, Caroline E. Mukherjee, Shayanti Nanomaterials (Basel) Review Pelvic organ prolapse (POP) is a hidden women’s health disorder that impacts 1 in 4 women across all age groups. Surgical intervention has been the only treatment option, often involving non-degradable meshes, with variable results. However, recent reports have highlighted the adverse effects of meshes in the long term, which involve unacceptable rates of erosion, chronic infection and severe pain related to mesh shrinkage. Therefore, there is an urgent unmet need to fabricate of new class of biocompatible meshes for the treatment of POP. This review focuses on the causes for the downfall of commercial meshes, and discusses the use of emerging technologies such as electrospinning and 3D printing to design new meshes. Furthermore, we discuss the impact and advantage of nano-/microstructured alternative meshes over commercial meshes with respect to their tissue integration performance. Considering the key challenges of current meshes, we discuss the potential of cell-based tissue engineering strategies to augment the new class of meshes to improve biocompatibility and immunomodulation. Finally, this review highlights the future direction in designing the new class of mesh to overcome the hurdles of foreign body rejection faced by the traditional meshes, in order to have safe and effective treatment for women in the long term. MDPI 2020-06-05 /pmc/articles/PMC7353440/ /pubmed/32517067 http://dx.doi.org/10.3390/nano10061120 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Paul, Kallyanashis
Darzi, Saeedeh
Werkmeister, Jerome A.
Gargett, Caroline E.
Mukherjee, Shayanti
Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction
title Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction
title_full Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction
title_fullStr Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction
title_full_unstemmed Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction
title_short Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction
title_sort emerging nano/micro-structured degradable polymeric meshes for pelvic floor reconstruction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353440/
https://www.ncbi.nlm.nih.gov/pubmed/32517067
http://dx.doi.org/10.3390/nano10061120
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