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TOCOSH FLOUR (Solanum tuberosum L.): A Toxicological Assessment of Traditional Peruvian Fermented Potatoes
Potato tocosh is a naturally processed potato for nutritional and curative purposes from traditional Peruvian medicine. The aim of this study was to investigate the acute and sub-acute toxicity of tocosh flour (TF). For sub-acute toxicity, TF was administered orally to rats daily once a day for 28 d...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353511/ https://www.ncbi.nlm.nih.gov/pubmed/32498434 http://dx.doi.org/10.3390/foods9060719 |
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author | Velasco-Chong, Jonas Roberto Herrera-Calderón, Oscar Rojas-Armas, Juan Pedro Hañari-Quispe, Renán Dilton Figueroa-Salvador, Linder Peña-Rojas, Gilmar Andía-Ayme, Vidalina Yuli-Posadas, Ricardo Ángel Yepes-Perez, Andres F. Aguilar, Cristian |
author_facet | Velasco-Chong, Jonas Roberto Herrera-Calderón, Oscar Rojas-Armas, Juan Pedro Hañari-Quispe, Renán Dilton Figueroa-Salvador, Linder Peña-Rojas, Gilmar Andía-Ayme, Vidalina Yuli-Posadas, Ricardo Ángel Yepes-Perez, Andres F. Aguilar, Cristian |
author_sort | Velasco-Chong, Jonas Roberto |
collection | PubMed |
description | Potato tocosh is a naturally processed potato for nutritional and curative purposes from traditional Peruvian medicine. The aim of this study was to investigate the acute and sub-acute toxicity of tocosh flour (TF). For sub-acute toxicity, TF was administered orally to rats daily once a day for 28 days at doses of 1000 mg/kg body weight (BW). Animals were observed for general behaviors, mortality, body weight variations, and histological analysis. At the end of treatment, relative organ weights, histopathology, hematological and biochemical parameters were analyzed. For acute toxicity, TF was administered orally to mice at doses of 2000 and 5000 mg/kg BW at a single dose in both sexes. Body weight, mortality, and clinical signs were observed for 14 days after treatment. The results of acute toxicity showed that the median lethal dose (LD(50)) value of TF is higher than 2000 g/kg BW but less than 5000 mg/Kg BW in mice. Death and toxicological symptoms were not found during the treatment. For sub-acute toxicity, we found that no-observed-adverse-effect levels (NOAEL) of TF in rats up to 1000 g/kg BW. There were statistically significant differences in body weight, and relative organ weight in the stomach and brain. No differences in hematological and biochemical parameters were observed when compared with the control group. For sub-acute toxicity, histopathological studies revealed minor abnormalities in liver and kidney tissues at doses of 5000 mg/Kg. Based on these results, TF is a traditional Peruvian medicine with high safety at up to 1000 mg/kg BW for 28 days in rats. |
format | Online Article Text |
id | pubmed-7353511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73535112020-07-15 TOCOSH FLOUR (Solanum tuberosum L.): A Toxicological Assessment of Traditional Peruvian Fermented Potatoes Velasco-Chong, Jonas Roberto Herrera-Calderón, Oscar Rojas-Armas, Juan Pedro Hañari-Quispe, Renán Dilton Figueroa-Salvador, Linder Peña-Rojas, Gilmar Andía-Ayme, Vidalina Yuli-Posadas, Ricardo Ángel Yepes-Perez, Andres F. Aguilar, Cristian Foods Article Potato tocosh is a naturally processed potato for nutritional and curative purposes from traditional Peruvian medicine. The aim of this study was to investigate the acute and sub-acute toxicity of tocosh flour (TF). For sub-acute toxicity, TF was administered orally to rats daily once a day for 28 days at doses of 1000 mg/kg body weight (BW). Animals were observed for general behaviors, mortality, body weight variations, and histological analysis. At the end of treatment, relative organ weights, histopathology, hematological and biochemical parameters were analyzed. For acute toxicity, TF was administered orally to mice at doses of 2000 and 5000 mg/kg BW at a single dose in both sexes. Body weight, mortality, and clinical signs were observed for 14 days after treatment. The results of acute toxicity showed that the median lethal dose (LD(50)) value of TF is higher than 2000 g/kg BW but less than 5000 mg/Kg BW in mice. Death and toxicological symptoms were not found during the treatment. For sub-acute toxicity, we found that no-observed-adverse-effect levels (NOAEL) of TF in rats up to 1000 g/kg BW. There were statistically significant differences in body weight, and relative organ weight in the stomach and brain. No differences in hematological and biochemical parameters were observed when compared with the control group. For sub-acute toxicity, histopathological studies revealed minor abnormalities in liver and kidney tissues at doses of 5000 mg/Kg. Based on these results, TF is a traditional Peruvian medicine with high safety at up to 1000 mg/kg BW for 28 days in rats. MDPI 2020-06-02 /pmc/articles/PMC7353511/ /pubmed/32498434 http://dx.doi.org/10.3390/foods9060719 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Velasco-Chong, Jonas Roberto Herrera-Calderón, Oscar Rojas-Armas, Juan Pedro Hañari-Quispe, Renán Dilton Figueroa-Salvador, Linder Peña-Rojas, Gilmar Andía-Ayme, Vidalina Yuli-Posadas, Ricardo Ángel Yepes-Perez, Andres F. Aguilar, Cristian TOCOSH FLOUR (Solanum tuberosum L.): A Toxicological Assessment of Traditional Peruvian Fermented Potatoes |
title | TOCOSH FLOUR (Solanum tuberosum L.): A Toxicological Assessment of Traditional Peruvian Fermented Potatoes |
title_full | TOCOSH FLOUR (Solanum tuberosum L.): A Toxicological Assessment of Traditional Peruvian Fermented Potatoes |
title_fullStr | TOCOSH FLOUR (Solanum tuberosum L.): A Toxicological Assessment of Traditional Peruvian Fermented Potatoes |
title_full_unstemmed | TOCOSH FLOUR (Solanum tuberosum L.): A Toxicological Assessment of Traditional Peruvian Fermented Potatoes |
title_short | TOCOSH FLOUR (Solanum tuberosum L.): A Toxicological Assessment of Traditional Peruvian Fermented Potatoes |
title_sort | tocosh flour (solanum tuberosum l.): a toxicological assessment of traditional peruvian fermented potatoes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353511/ https://www.ncbi.nlm.nih.gov/pubmed/32498434 http://dx.doi.org/10.3390/foods9060719 |
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