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The Antioxidant and Anti-Inflammatory Properties of Rice Bran Phenolic Extracts

Oxidative stress and inflammation are known to be linked to the development of chronic inflammatory conditions, such as type 2 diabetes and cardiovascular disease. Dietary polyphenols have been demonstrated to contain potent bioactivity against specific inflammatory pathways. Rice bran (RB), a by-pr...

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Autores principales: Saji, Nancy, Francis, Nidhish, Schwarz, Lachlan J., Blanchard, Christopher L., Santhakumar, Abishek B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353521/
https://www.ncbi.nlm.nih.gov/pubmed/32599964
http://dx.doi.org/10.3390/foods9060829
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author Saji, Nancy
Francis, Nidhish
Schwarz, Lachlan J.
Blanchard, Christopher L.
Santhakumar, Abishek B.
author_facet Saji, Nancy
Francis, Nidhish
Schwarz, Lachlan J.
Blanchard, Christopher L.
Santhakumar, Abishek B.
author_sort Saji, Nancy
collection PubMed
description Oxidative stress and inflammation are known to be linked to the development of chronic inflammatory conditions, such as type 2 diabetes and cardiovascular disease. Dietary polyphenols have been demonstrated to contain potent bioactivity against specific inflammatory pathways. Rice bran (RB), a by-product generated during the rice milling process, is normally used in animal feed or discarded due to its rancidity. However, RB is known to be abundant in bioactive polyphenols including phenolic acids. This study investigates the antioxidant and anti-inflammatory effects of RB phenolic extracts (25, 50, 100, and 250 µg/mL) on RAW264.7 mouse macrophage cells stimulated with hydrogen peroxide and lipopolysaccharide. Biomarkers of oxidative stress and inflammation such as malondialdehyde (MDA), intracellular reactive oxygen species, nitric oxide and pro-inflammatory cytokines such as interleukin-6 (IL-6), monocyte chemoattractant protein 1 (MCP-1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), interleukin-12, p70 (IL-12p70), and interferon-γ (IFN-γ) were measured in vitro. Treatment with RB extracts significantly decreased the production of MDA, intracellular reactive oxygen species, nitric oxide and pro-inflammatory cytokines (IL-6, IL-12p70, and IFN-γ) when compared to the control. It is proposed that RB phenolic extracts, via their metal chelating properties and free radical scavenging activity, target pathways of oxidative stress and inflammation resulting in the alleviation of vascular inflammatory mediators.
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spelling pubmed-73535212020-07-15 The Antioxidant and Anti-Inflammatory Properties of Rice Bran Phenolic Extracts Saji, Nancy Francis, Nidhish Schwarz, Lachlan J. Blanchard, Christopher L. Santhakumar, Abishek B. Foods Article Oxidative stress and inflammation are known to be linked to the development of chronic inflammatory conditions, such as type 2 diabetes and cardiovascular disease. Dietary polyphenols have been demonstrated to contain potent bioactivity against specific inflammatory pathways. Rice bran (RB), a by-product generated during the rice milling process, is normally used in animal feed or discarded due to its rancidity. However, RB is known to be abundant in bioactive polyphenols including phenolic acids. This study investigates the antioxidant and anti-inflammatory effects of RB phenolic extracts (25, 50, 100, and 250 µg/mL) on RAW264.7 mouse macrophage cells stimulated with hydrogen peroxide and lipopolysaccharide. Biomarkers of oxidative stress and inflammation such as malondialdehyde (MDA), intracellular reactive oxygen species, nitric oxide and pro-inflammatory cytokines such as interleukin-6 (IL-6), monocyte chemoattractant protein 1 (MCP-1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), interleukin-12, p70 (IL-12p70), and interferon-γ (IFN-γ) were measured in vitro. Treatment with RB extracts significantly decreased the production of MDA, intracellular reactive oxygen species, nitric oxide and pro-inflammatory cytokines (IL-6, IL-12p70, and IFN-γ) when compared to the control. It is proposed that RB phenolic extracts, via their metal chelating properties and free radical scavenging activity, target pathways of oxidative stress and inflammation resulting in the alleviation of vascular inflammatory mediators. MDPI 2020-06-24 /pmc/articles/PMC7353521/ /pubmed/32599964 http://dx.doi.org/10.3390/foods9060829 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Saji, Nancy
Francis, Nidhish
Schwarz, Lachlan J.
Blanchard, Christopher L.
Santhakumar, Abishek B.
The Antioxidant and Anti-Inflammatory Properties of Rice Bran Phenolic Extracts
title The Antioxidant and Anti-Inflammatory Properties of Rice Bran Phenolic Extracts
title_full The Antioxidant and Anti-Inflammatory Properties of Rice Bran Phenolic Extracts
title_fullStr The Antioxidant and Anti-Inflammatory Properties of Rice Bran Phenolic Extracts
title_full_unstemmed The Antioxidant and Anti-Inflammatory Properties of Rice Bran Phenolic Extracts
title_short The Antioxidant and Anti-Inflammatory Properties of Rice Bran Phenolic Extracts
title_sort antioxidant and anti-inflammatory properties of rice bran phenolic extracts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353521/
https://www.ncbi.nlm.nih.gov/pubmed/32599964
http://dx.doi.org/10.3390/foods9060829
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