Cargando…
The Antioxidant and Anti-Inflammatory Properties of Rice Bran Phenolic Extracts
Oxidative stress and inflammation are known to be linked to the development of chronic inflammatory conditions, such as type 2 diabetes and cardiovascular disease. Dietary polyphenols have been demonstrated to contain potent bioactivity against specific inflammatory pathways. Rice bran (RB), a by-pr...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353521/ https://www.ncbi.nlm.nih.gov/pubmed/32599964 http://dx.doi.org/10.3390/foods9060829 |
_version_ | 1783557895538868224 |
---|---|
author | Saji, Nancy Francis, Nidhish Schwarz, Lachlan J. Blanchard, Christopher L. Santhakumar, Abishek B. |
author_facet | Saji, Nancy Francis, Nidhish Schwarz, Lachlan J. Blanchard, Christopher L. Santhakumar, Abishek B. |
author_sort | Saji, Nancy |
collection | PubMed |
description | Oxidative stress and inflammation are known to be linked to the development of chronic inflammatory conditions, such as type 2 diabetes and cardiovascular disease. Dietary polyphenols have been demonstrated to contain potent bioactivity against specific inflammatory pathways. Rice bran (RB), a by-product generated during the rice milling process, is normally used in animal feed or discarded due to its rancidity. However, RB is known to be abundant in bioactive polyphenols including phenolic acids. This study investigates the antioxidant and anti-inflammatory effects of RB phenolic extracts (25, 50, 100, and 250 µg/mL) on RAW264.7 mouse macrophage cells stimulated with hydrogen peroxide and lipopolysaccharide. Biomarkers of oxidative stress and inflammation such as malondialdehyde (MDA), intracellular reactive oxygen species, nitric oxide and pro-inflammatory cytokines such as interleukin-6 (IL-6), monocyte chemoattractant protein 1 (MCP-1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), interleukin-12, p70 (IL-12p70), and interferon-γ (IFN-γ) were measured in vitro. Treatment with RB extracts significantly decreased the production of MDA, intracellular reactive oxygen species, nitric oxide and pro-inflammatory cytokines (IL-6, IL-12p70, and IFN-γ) when compared to the control. It is proposed that RB phenolic extracts, via their metal chelating properties and free radical scavenging activity, target pathways of oxidative stress and inflammation resulting in the alleviation of vascular inflammatory mediators. |
format | Online Article Text |
id | pubmed-7353521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73535212020-07-15 The Antioxidant and Anti-Inflammatory Properties of Rice Bran Phenolic Extracts Saji, Nancy Francis, Nidhish Schwarz, Lachlan J. Blanchard, Christopher L. Santhakumar, Abishek B. Foods Article Oxidative stress and inflammation are known to be linked to the development of chronic inflammatory conditions, such as type 2 diabetes and cardiovascular disease. Dietary polyphenols have been demonstrated to contain potent bioactivity against specific inflammatory pathways. Rice bran (RB), a by-product generated during the rice milling process, is normally used in animal feed or discarded due to its rancidity. However, RB is known to be abundant in bioactive polyphenols including phenolic acids. This study investigates the antioxidant and anti-inflammatory effects of RB phenolic extracts (25, 50, 100, and 250 µg/mL) on RAW264.7 mouse macrophage cells stimulated with hydrogen peroxide and lipopolysaccharide. Biomarkers of oxidative stress and inflammation such as malondialdehyde (MDA), intracellular reactive oxygen species, nitric oxide and pro-inflammatory cytokines such as interleukin-6 (IL-6), monocyte chemoattractant protein 1 (MCP-1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), interleukin-12, p70 (IL-12p70), and interferon-γ (IFN-γ) were measured in vitro. Treatment with RB extracts significantly decreased the production of MDA, intracellular reactive oxygen species, nitric oxide and pro-inflammatory cytokines (IL-6, IL-12p70, and IFN-γ) when compared to the control. It is proposed that RB phenolic extracts, via their metal chelating properties and free radical scavenging activity, target pathways of oxidative stress and inflammation resulting in the alleviation of vascular inflammatory mediators. MDPI 2020-06-24 /pmc/articles/PMC7353521/ /pubmed/32599964 http://dx.doi.org/10.3390/foods9060829 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Saji, Nancy Francis, Nidhish Schwarz, Lachlan J. Blanchard, Christopher L. Santhakumar, Abishek B. The Antioxidant and Anti-Inflammatory Properties of Rice Bran Phenolic Extracts |
title | The Antioxidant and Anti-Inflammatory Properties of Rice Bran Phenolic Extracts |
title_full | The Antioxidant and Anti-Inflammatory Properties of Rice Bran Phenolic Extracts |
title_fullStr | The Antioxidant and Anti-Inflammatory Properties of Rice Bran Phenolic Extracts |
title_full_unstemmed | The Antioxidant and Anti-Inflammatory Properties of Rice Bran Phenolic Extracts |
title_short | The Antioxidant and Anti-Inflammatory Properties of Rice Bran Phenolic Extracts |
title_sort | antioxidant and anti-inflammatory properties of rice bran phenolic extracts |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353521/ https://www.ncbi.nlm.nih.gov/pubmed/32599964 http://dx.doi.org/10.3390/foods9060829 |
work_keys_str_mv | AT sajinancy theantioxidantandantiinflammatorypropertiesofricebranphenolicextracts AT francisnidhish theantioxidantandantiinflammatorypropertiesofricebranphenolicextracts AT schwarzlachlanj theantioxidantandantiinflammatorypropertiesofricebranphenolicextracts AT blanchardchristopherl theantioxidantandantiinflammatorypropertiesofricebranphenolicextracts AT santhakumarabishekb theantioxidantandantiinflammatorypropertiesofricebranphenolicextracts AT sajinancy antioxidantandantiinflammatorypropertiesofricebranphenolicextracts AT francisnidhish antioxidantandantiinflammatorypropertiesofricebranphenolicextracts AT schwarzlachlanj antioxidantandantiinflammatorypropertiesofricebranphenolicextracts AT blanchardchristopherl antioxidantandantiinflammatorypropertiesofricebranphenolicextracts AT santhakumarabishekb antioxidantandantiinflammatorypropertiesofricebranphenolicextracts |