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Open-Cell Tizr-Based Bulk Metallic Glass Scaffolds with Excellent Biocompatibility and Suitable Mechanical Properties for Biomedical Application

A series of biocompatible high-porosity (up to 72.4%) TiZr-based porous bulk metallic glass (BMG) scaffolds were successfully fabricated by hot pressing a mixture of toxic element-free TiZr-based BMG powder and an Al particle space holder. The morphology of the fabricated scaffolds was similar to th...

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Autores principales: Nguyen, Van Tai, Wong, Xavier Pei-Chun, Song, Sin-Mao, Tsai, Pei-Hua, Jang, Jason Shian-Ching, Tsao, I-Yu, Lin, Che-Hsin, Nguyen, Van Cuong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353611/
https://www.ncbi.nlm.nih.gov/pubmed/32370007
http://dx.doi.org/10.3390/jfb11020028
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author Nguyen, Van Tai
Wong, Xavier Pei-Chun
Song, Sin-Mao
Tsai, Pei-Hua
Jang, Jason Shian-Ching
Tsao, I-Yu
Lin, Che-Hsin
Nguyen, Van Cuong
author_facet Nguyen, Van Tai
Wong, Xavier Pei-Chun
Song, Sin-Mao
Tsai, Pei-Hua
Jang, Jason Shian-Ching
Tsao, I-Yu
Lin, Che-Hsin
Nguyen, Van Cuong
author_sort Nguyen, Van Tai
collection PubMed
description A series of biocompatible high-porosity (up to 72.4%) TiZr-based porous bulk metallic glass (BMG) scaffolds were successfully fabricated by hot pressing a mixture of toxic element-free TiZr-based BMG powder and an Al particle space holder. The morphology of the fabricated scaffolds was similar to that of human bones, with pore sizes ranging from 75 to 250 μm. X-ray diffraction patterns and transmission electron microscopy images indicated that the amorphous structure of the TiZr-based BMG scaffolds remained in the amorphous state after hot pressing. Noncytotoxicity and extracellular calcium deposition of the TiZr-based BMG scaffolds at porosities of 32.8%, 48.8%, and 64.0% were examined by using the direct contact method. The results showed that the BMG scaffolds possess high cell viability and extracellular calcium deposition with average cell survival and deposition rates of approximately 170.1% and 130.9%, respectively. In addition, the resulting TiZr-based BMG scaffolds exhibited a considerable reduction in Young’s moduli from 56.4 to 2.3 GPa, compressive strength from 979 to 19 MPa, and bending strength from 157 MPa to 49 MPa when the porosity was gradually increased from 2.0% to 72.4%. Based on the aforementioned specific characteristics, TiZr-based BMG scaffolds can be considered as potential candidates for biomedical applications in the human body.
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spelling pubmed-73536112020-07-21 Open-Cell Tizr-Based Bulk Metallic Glass Scaffolds with Excellent Biocompatibility and Suitable Mechanical Properties for Biomedical Application Nguyen, Van Tai Wong, Xavier Pei-Chun Song, Sin-Mao Tsai, Pei-Hua Jang, Jason Shian-Ching Tsao, I-Yu Lin, Che-Hsin Nguyen, Van Cuong J Funct Biomater Article A series of biocompatible high-porosity (up to 72.4%) TiZr-based porous bulk metallic glass (BMG) scaffolds were successfully fabricated by hot pressing a mixture of toxic element-free TiZr-based BMG powder and an Al particle space holder. The morphology of the fabricated scaffolds was similar to that of human bones, with pore sizes ranging from 75 to 250 μm. X-ray diffraction patterns and transmission electron microscopy images indicated that the amorphous structure of the TiZr-based BMG scaffolds remained in the amorphous state after hot pressing. Noncytotoxicity and extracellular calcium deposition of the TiZr-based BMG scaffolds at porosities of 32.8%, 48.8%, and 64.0% were examined by using the direct contact method. The results showed that the BMG scaffolds possess high cell viability and extracellular calcium deposition with average cell survival and deposition rates of approximately 170.1% and 130.9%, respectively. In addition, the resulting TiZr-based BMG scaffolds exhibited a considerable reduction in Young’s moduli from 56.4 to 2.3 GPa, compressive strength from 979 to 19 MPa, and bending strength from 157 MPa to 49 MPa when the porosity was gradually increased from 2.0% to 72.4%. Based on the aforementioned specific characteristics, TiZr-based BMG scaffolds can be considered as potential candidates for biomedical applications in the human body. MDPI 2020-05-01 /pmc/articles/PMC7353611/ /pubmed/32370007 http://dx.doi.org/10.3390/jfb11020028 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nguyen, Van Tai
Wong, Xavier Pei-Chun
Song, Sin-Mao
Tsai, Pei-Hua
Jang, Jason Shian-Ching
Tsao, I-Yu
Lin, Che-Hsin
Nguyen, Van Cuong
Open-Cell Tizr-Based Bulk Metallic Glass Scaffolds with Excellent Biocompatibility and Suitable Mechanical Properties for Biomedical Application
title Open-Cell Tizr-Based Bulk Metallic Glass Scaffolds with Excellent Biocompatibility and Suitable Mechanical Properties for Biomedical Application
title_full Open-Cell Tizr-Based Bulk Metallic Glass Scaffolds with Excellent Biocompatibility and Suitable Mechanical Properties for Biomedical Application
title_fullStr Open-Cell Tizr-Based Bulk Metallic Glass Scaffolds with Excellent Biocompatibility and Suitable Mechanical Properties for Biomedical Application
title_full_unstemmed Open-Cell Tizr-Based Bulk Metallic Glass Scaffolds with Excellent Biocompatibility and Suitable Mechanical Properties for Biomedical Application
title_short Open-Cell Tizr-Based Bulk Metallic Glass Scaffolds with Excellent Biocompatibility and Suitable Mechanical Properties for Biomedical Application
title_sort open-cell tizr-based bulk metallic glass scaffolds with excellent biocompatibility and suitable mechanical properties for biomedical application
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353611/
https://www.ncbi.nlm.nih.gov/pubmed/32370007
http://dx.doi.org/10.3390/jfb11020028
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