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Chemical Characterization and Bioactive Properties of Different Extracts from Fibigia clypeata, an Unexplored Plant Food
Fibigia clypeata (L.) Medik. is a poorly studied plant species belonging to the Brassicaceae family, and usually used as cress in the salads. The current investigation aimed at assessing the antioxidant potential and inhibitory activity of ethyl acetate, methanol, and aqueous extracts of F. clypeata...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353635/ https://www.ncbi.nlm.nih.gov/pubmed/32492817 http://dx.doi.org/10.3390/foods9060705 |
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author | Zengin, Gokhan Mahomoodally, Mohamad Fawzi Rocchetti, Gabriele Lucini, Luigi Sieniawska, Elwira Świątek, Łukasz Rajtar, Barbara Polz-Dacewicz, Małgorzata Senkardes, Ismail Aktumsek, Abdurrahman Picot-Allain, Marie Carene Nancy Montesano, Domenico |
author_facet | Zengin, Gokhan Mahomoodally, Mohamad Fawzi Rocchetti, Gabriele Lucini, Luigi Sieniawska, Elwira Świątek, Łukasz Rajtar, Barbara Polz-Dacewicz, Małgorzata Senkardes, Ismail Aktumsek, Abdurrahman Picot-Allain, Marie Carene Nancy Montesano, Domenico |
author_sort | Zengin, Gokhan |
collection | PubMed |
description | Fibigia clypeata (L.) Medik. is a poorly studied plant species belonging to the Brassicaceae family, and usually used as cress in the salads. The current investigation aimed at assessing the antioxidant potential and inhibitory activity of ethyl acetate, methanol, and aqueous extracts of F. clypeata against key enzymes targeted in the management of type II diabetes (α-amylase and α-glucosidase), Alzheimer’s disease (acetylcholinesterase and butyrylcholinesterase), and skin hyperpigmentation (tyrosinase). Cytotoxicity of the extracts was also determined using normal VERO and cancer FaDu and SCC-25 cell lines. Besides, LC-MS was employed to investigate the detailed phytochemical profiles of the extracts. The methanol extract showed potent enzyme inhibitory activity (4.87 mg galantamine equivalent/g, 3.52 mg galantamine equivalent/g, 126.80 mg kojic acid equivalent/g, and 24.68 mg acarbose equivalent/g, for acetylcholinesterase, butyrylcholinesterase, tyrosinase, and α-glucosidase, respectively) and antioxidant potential (96.52, 109.10, 154.02, and 104.85 mg trolox equivalent/g, for DPPH, ABTS, CUPRAC, and FRAP assays, respectively). Interestingly, caffeic acid-O-hexoside derivative, caffeyl alcohol O-glucopyranoside, and ferulic acid derivative were identified in all extracts. F. clypeata extracts showed no cytotoxicity towards VERO cell line and a weak cytotoxic potential against FaDu and SCC-25 cell lines. Interesting scientific evidence gathered from the present study support further investigation on F. clypeata in the view of designing and developing a novel therapeutic agent for the management of Alzheimer’s disease, type II diabetes, skin hyperpigmentation problems, as well as cancer. |
format | Online Article Text |
id | pubmed-7353635 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73536352020-07-21 Chemical Characterization and Bioactive Properties of Different Extracts from Fibigia clypeata, an Unexplored Plant Food Zengin, Gokhan Mahomoodally, Mohamad Fawzi Rocchetti, Gabriele Lucini, Luigi Sieniawska, Elwira Świątek, Łukasz Rajtar, Barbara Polz-Dacewicz, Małgorzata Senkardes, Ismail Aktumsek, Abdurrahman Picot-Allain, Marie Carene Nancy Montesano, Domenico Foods Article Fibigia clypeata (L.) Medik. is a poorly studied plant species belonging to the Brassicaceae family, and usually used as cress in the salads. The current investigation aimed at assessing the antioxidant potential and inhibitory activity of ethyl acetate, methanol, and aqueous extracts of F. clypeata against key enzymes targeted in the management of type II diabetes (α-amylase and α-glucosidase), Alzheimer’s disease (acetylcholinesterase and butyrylcholinesterase), and skin hyperpigmentation (tyrosinase). Cytotoxicity of the extracts was also determined using normal VERO and cancer FaDu and SCC-25 cell lines. Besides, LC-MS was employed to investigate the detailed phytochemical profiles of the extracts. The methanol extract showed potent enzyme inhibitory activity (4.87 mg galantamine equivalent/g, 3.52 mg galantamine equivalent/g, 126.80 mg kojic acid equivalent/g, and 24.68 mg acarbose equivalent/g, for acetylcholinesterase, butyrylcholinesterase, tyrosinase, and α-glucosidase, respectively) and antioxidant potential (96.52, 109.10, 154.02, and 104.85 mg trolox equivalent/g, for DPPH, ABTS, CUPRAC, and FRAP assays, respectively). Interestingly, caffeic acid-O-hexoside derivative, caffeyl alcohol O-glucopyranoside, and ferulic acid derivative were identified in all extracts. F. clypeata extracts showed no cytotoxicity towards VERO cell line and a weak cytotoxic potential against FaDu and SCC-25 cell lines. Interesting scientific evidence gathered from the present study support further investigation on F. clypeata in the view of designing and developing a novel therapeutic agent for the management of Alzheimer’s disease, type II diabetes, skin hyperpigmentation problems, as well as cancer. MDPI 2020-06-01 /pmc/articles/PMC7353635/ /pubmed/32492817 http://dx.doi.org/10.3390/foods9060705 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zengin, Gokhan Mahomoodally, Mohamad Fawzi Rocchetti, Gabriele Lucini, Luigi Sieniawska, Elwira Świątek, Łukasz Rajtar, Barbara Polz-Dacewicz, Małgorzata Senkardes, Ismail Aktumsek, Abdurrahman Picot-Allain, Marie Carene Nancy Montesano, Domenico Chemical Characterization and Bioactive Properties of Different Extracts from Fibigia clypeata, an Unexplored Plant Food |
title | Chemical Characterization and Bioactive Properties of Different Extracts from Fibigia clypeata, an Unexplored Plant Food |
title_full | Chemical Characterization and Bioactive Properties of Different Extracts from Fibigia clypeata, an Unexplored Plant Food |
title_fullStr | Chemical Characterization and Bioactive Properties of Different Extracts from Fibigia clypeata, an Unexplored Plant Food |
title_full_unstemmed | Chemical Characterization and Bioactive Properties of Different Extracts from Fibigia clypeata, an Unexplored Plant Food |
title_short | Chemical Characterization and Bioactive Properties of Different Extracts from Fibigia clypeata, an Unexplored Plant Food |
title_sort | chemical characterization and bioactive properties of different extracts from fibigia clypeata, an unexplored plant food |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353635/ https://www.ncbi.nlm.nih.gov/pubmed/32492817 http://dx.doi.org/10.3390/foods9060705 |
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