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Chemical Characterization and Bioactive Properties of Different Extracts from Fibigia clypeata, an Unexplored Plant Food

Fibigia clypeata (L.) Medik. is a poorly studied plant species belonging to the Brassicaceae family, and usually used as cress in the salads. The current investigation aimed at assessing the antioxidant potential and inhibitory activity of ethyl acetate, methanol, and aqueous extracts of F. clypeata...

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Autores principales: Zengin, Gokhan, Mahomoodally, Mohamad Fawzi, Rocchetti, Gabriele, Lucini, Luigi, Sieniawska, Elwira, Świątek, Łukasz, Rajtar, Barbara, Polz-Dacewicz, Małgorzata, Senkardes, Ismail, Aktumsek, Abdurrahman, Picot-Allain, Marie Carene Nancy, Montesano, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353635/
https://www.ncbi.nlm.nih.gov/pubmed/32492817
http://dx.doi.org/10.3390/foods9060705
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author Zengin, Gokhan
Mahomoodally, Mohamad Fawzi
Rocchetti, Gabriele
Lucini, Luigi
Sieniawska, Elwira
Świątek, Łukasz
Rajtar, Barbara
Polz-Dacewicz, Małgorzata
Senkardes, Ismail
Aktumsek, Abdurrahman
Picot-Allain, Marie Carene Nancy
Montesano, Domenico
author_facet Zengin, Gokhan
Mahomoodally, Mohamad Fawzi
Rocchetti, Gabriele
Lucini, Luigi
Sieniawska, Elwira
Świątek, Łukasz
Rajtar, Barbara
Polz-Dacewicz, Małgorzata
Senkardes, Ismail
Aktumsek, Abdurrahman
Picot-Allain, Marie Carene Nancy
Montesano, Domenico
author_sort Zengin, Gokhan
collection PubMed
description Fibigia clypeata (L.) Medik. is a poorly studied plant species belonging to the Brassicaceae family, and usually used as cress in the salads. The current investigation aimed at assessing the antioxidant potential and inhibitory activity of ethyl acetate, methanol, and aqueous extracts of F. clypeata against key enzymes targeted in the management of type II diabetes (α-amylase and α-glucosidase), Alzheimer’s disease (acetylcholinesterase and butyrylcholinesterase), and skin hyperpigmentation (tyrosinase). Cytotoxicity of the extracts was also determined using normal VERO and cancer FaDu and SCC-25 cell lines. Besides, LC-MS was employed to investigate the detailed phytochemical profiles of the extracts. The methanol extract showed potent enzyme inhibitory activity (4.87 mg galantamine equivalent/g, 3.52 mg galantamine equivalent/g, 126.80 mg kojic acid equivalent/g, and 24.68 mg acarbose equivalent/g, for acetylcholinesterase, butyrylcholinesterase, tyrosinase, and α-glucosidase, respectively) and antioxidant potential (96.52, 109.10, 154.02, and 104.85 mg trolox equivalent/g, for DPPH, ABTS, CUPRAC, and FRAP assays, respectively). Interestingly, caffeic acid-O-hexoside derivative, caffeyl alcohol O-glucopyranoside, and ferulic acid derivative were identified in all extracts. F. clypeata extracts showed no cytotoxicity towards VERO cell line and a weak cytotoxic potential against FaDu and SCC-25 cell lines. Interesting scientific evidence gathered from the present study support further investigation on F. clypeata in the view of designing and developing a novel therapeutic agent for the management of Alzheimer’s disease, type II diabetes, skin hyperpigmentation problems, as well as cancer.
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spelling pubmed-73536352020-07-21 Chemical Characterization and Bioactive Properties of Different Extracts from Fibigia clypeata, an Unexplored Plant Food Zengin, Gokhan Mahomoodally, Mohamad Fawzi Rocchetti, Gabriele Lucini, Luigi Sieniawska, Elwira Świątek, Łukasz Rajtar, Barbara Polz-Dacewicz, Małgorzata Senkardes, Ismail Aktumsek, Abdurrahman Picot-Allain, Marie Carene Nancy Montesano, Domenico Foods Article Fibigia clypeata (L.) Medik. is a poorly studied plant species belonging to the Brassicaceae family, and usually used as cress in the salads. The current investigation aimed at assessing the antioxidant potential and inhibitory activity of ethyl acetate, methanol, and aqueous extracts of F. clypeata against key enzymes targeted in the management of type II diabetes (α-amylase and α-glucosidase), Alzheimer’s disease (acetylcholinesterase and butyrylcholinesterase), and skin hyperpigmentation (tyrosinase). Cytotoxicity of the extracts was also determined using normal VERO and cancer FaDu and SCC-25 cell lines. Besides, LC-MS was employed to investigate the detailed phytochemical profiles of the extracts. The methanol extract showed potent enzyme inhibitory activity (4.87 mg galantamine equivalent/g, 3.52 mg galantamine equivalent/g, 126.80 mg kojic acid equivalent/g, and 24.68 mg acarbose equivalent/g, for acetylcholinesterase, butyrylcholinesterase, tyrosinase, and α-glucosidase, respectively) and antioxidant potential (96.52, 109.10, 154.02, and 104.85 mg trolox equivalent/g, for DPPH, ABTS, CUPRAC, and FRAP assays, respectively). Interestingly, caffeic acid-O-hexoside derivative, caffeyl alcohol O-glucopyranoside, and ferulic acid derivative were identified in all extracts. F. clypeata extracts showed no cytotoxicity towards VERO cell line and a weak cytotoxic potential against FaDu and SCC-25 cell lines. Interesting scientific evidence gathered from the present study support further investigation on F. clypeata in the view of designing and developing a novel therapeutic agent for the management of Alzheimer’s disease, type II diabetes, skin hyperpigmentation problems, as well as cancer. MDPI 2020-06-01 /pmc/articles/PMC7353635/ /pubmed/32492817 http://dx.doi.org/10.3390/foods9060705 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zengin, Gokhan
Mahomoodally, Mohamad Fawzi
Rocchetti, Gabriele
Lucini, Luigi
Sieniawska, Elwira
Świątek, Łukasz
Rajtar, Barbara
Polz-Dacewicz, Małgorzata
Senkardes, Ismail
Aktumsek, Abdurrahman
Picot-Allain, Marie Carene Nancy
Montesano, Domenico
Chemical Characterization and Bioactive Properties of Different Extracts from Fibigia clypeata, an Unexplored Plant Food
title Chemical Characterization and Bioactive Properties of Different Extracts from Fibigia clypeata, an Unexplored Plant Food
title_full Chemical Characterization and Bioactive Properties of Different Extracts from Fibigia clypeata, an Unexplored Plant Food
title_fullStr Chemical Characterization and Bioactive Properties of Different Extracts from Fibigia clypeata, an Unexplored Plant Food
title_full_unstemmed Chemical Characterization and Bioactive Properties of Different Extracts from Fibigia clypeata, an Unexplored Plant Food
title_short Chemical Characterization and Bioactive Properties of Different Extracts from Fibigia clypeata, an Unexplored Plant Food
title_sort chemical characterization and bioactive properties of different extracts from fibigia clypeata, an unexplored plant food
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353635/
https://www.ncbi.nlm.nih.gov/pubmed/32492817
http://dx.doi.org/10.3390/foods9060705
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