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The 2017 global point prevalence survey of antimicrobial consumption and resistance in Canadian hospitals

BACKGROUND: Patient-level surveillance (indication, appropriate choice, dosing, route, duration) of antimicrobial use in Canadian hospitals is needed to reduce antimicrobial overuse and misuse. Patient-level surveillance has not been performed on a national level in Canada. The Global Point Prevalen...

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Autores principales: Frenette, Charles, Sperlea, David, German, Greg J., Afra, Kevin, Boswell, Jennifer, Chang, Sandra, Goossens, Herman, Grant, Jennifer, Lefebvre, Marie-Astrid, McGeer, Allison, Mertz, Dominic, Science, Michelle, Versporten, Ann, Thirion, Daniel J. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353732/
https://www.ncbi.nlm.nih.gov/pubmed/32653046
http://dx.doi.org/10.1186/s13756-020-00758-x
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author Frenette, Charles
Sperlea, David
German, Greg J.
Afra, Kevin
Boswell, Jennifer
Chang, Sandra
Goossens, Herman
Grant, Jennifer
Lefebvre, Marie-Astrid
McGeer, Allison
Mertz, Dominic
Science, Michelle
Versporten, Ann
Thirion, Daniel J. G.
author_facet Frenette, Charles
Sperlea, David
German, Greg J.
Afra, Kevin
Boswell, Jennifer
Chang, Sandra
Goossens, Herman
Grant, Jennifer
Lefebvre, Marie-Astrid
McGeer, Allison
Mertz, Dominic
Science, Michelle
Versporten, Ann
Thirion, Daniel J. G.
author_sort Frenette, Charles
collection PubMed
description BACKGROUND: Patient-level surveillance (indication, appropriate choice, dosing, route, duration) of antimicrobial use in Canadian hospitals is needed to reduce antimicrobial overuse and misuse. Patient-level surveillance has not been performed on a national level in Canada. The Global Point Prevalence Survey of Antimicrobial Consumption and Resistance (Global-PPS) is an international collaborative to monitor antimicrobial use and resistance in hospitals worldwide. Global-PPS locally documents on a single day patient-level antimicrobial prescribing practices. This article presents the results of the 2017 Global-PPS in Canadian hospitals with established antimicrobial stewardship programs. METHODS: Hospitals part of the Canadian Nosocomial Infection Surveillance Program were invited to participate. Surveys could be performed any time in the 2017 calendar year. All in-patient wards in each hospital were surveyed by a physician, pharmacist or nurse with infectious disease training. RESULTS: Fourteen Canadian hospitals participated in the survey. Of 4118 patients, 1400 patients (34.0%) received a total of 2041 antimicrobials. Overall, 73.1% (n = 1493) of antimicrobials were for therapeutic use, 14.2% (n = 288) were for medical prophylaxis, 8.3% (n = 170) were for surgical prophylaxis, 1.8% (n = 37) were for other reasons, and 0.2% (n = 3) were used as prokinetic agents. Only 2.5% (n = 50) were for unknown reasons. For antimicrobials for therapeutic use, 29.9% of patients were treated for lower respiratory tract (343/1147), 10.5% for intra-abdominal (120/1147), 9.3% for skin and soft tissue (107/1147) and 7.5% for gastro-intestinal (86/1147) infections. CONCLUSIONS: Standardized methodology amongst Global-PPSs allows the comparison of our results to the 2015 Global-PPS. The prevalence of antimicrobial use on medical, surgical, and intensive care wards are similar to those previously observed in North America. Indication of antimicrobials has not been previously reported on such a large scale in Canadian hospitals. This report serves as a comparison for further point prevalence surveys that are currently underway. It will be used for identifying opportunities and benchmarking in antibiotic stewardship.
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spelling pubmed-73537322020-07-15 The 2017 global point prevalence survey of antimicrobial consumption and resistance in Canadian hospitals Frenette, Charles Sperlea, David German, Greg J. Afra, Kevin Boswell, Jennifer Chang, Sandra Goossens, Herman Grant, Jennifer Lefebvre, Marie-Astrid McGeer, Allison Mertz, Dominic Science, Michelle Versporten, Ann Thirion, Daniel J. G. Antimicrob Resist Infect Control Research BACKGROUND: Patient-level surveillance (indication, appropriate choice, dosing, route, duration) of antimicrobial use in Canadian hospitals is needed to reduce antimicrobial overuse and misuse. Patient-level surveillance has not been performed on a national level in Canada. The Global Point Prevalence Survey of Antimicrobial Consumption and Resistance (Global-PPS) is an international collaborative to monitor antimicrobial use and resistance in hospitals worldwide. Global-PPS locally documents on a single day patient-level antimicrobial prescribing practices. This article presents the results of the 2017 Global-PPS in Canadian hospitals with established antimicrobial stewardship programs. METHODS: Hospitals part of the Canadian Nosocomial Infection Surveillance Program were invited to participate. Surveys could be performed any time in the 2017 calendar year. All in-patient wards in each hospital were surveyed by a physician, pharmacist or nurse with infectious disease training. RESULTS: Fourteen Canadian hospitals participated in the survey. Of 4118 patients, 1400 patients (34.0%) received a total of 2041 antimicrobials. Overall, 73.1% (n = 1493) of antimicrobials were for therapeutic use, 14.2% (n = 288) were for medical prophylaxis, 8.3% (n = 170) were for surgical prophylaxis, 1.8% (n = 37) were for other reasons, and 0.2% (n = 3) were used as prokinetic agents. Only 2.5% (n = 50) were for unknown reasons. For antimicrobials for therapeutic use, 29.9% of patients were treated for lower respiratory tract (343/1147), 10.5% for intra-abdominal (120/1147), 9.3% for skin and soft tissue (107/1147) and 7.5% for gastro-intestinal (86/1147) infections. CONCLUSIONS: Standardized methodology amongst Global-PPSs allows the comparison of our results to the 2015 Global-PPS. The prevalence of antimicrobial use on medical, surgical, and intensive care wards are similar to those previously observed in North America. Indication of antimicrobials has not been previously reported on such a large scale in Canadian hospitals. This report serves as a comparison for further point prevalence surveys that are currently underway. It will be used for identifying opportunities and benchmarking in antibiotic stewardship. BioMed Central 2020-07-11 /pmc/articles/PMC7353732/ /pubmed/32653046 http://dx.doi.org/10.1186/s13756-020-00758-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Frenette, Charles
Sperlea, David
German, Greg J.
Afra, Kevin
Boswell, Jennifer
Chang, Sandra
Goossens, Herman
Grant, Jennifer
Lefebvre, Marie-Astrid
McGeer, Allison
Mertz, Dominic
Science, Michelle
Versporten, Ann
Thirion, Daniel J. G.
The 2017 global point prevalence survey of antimicrobial consumption and resistance in Canadian hospitals
title The 2017 global point prevalence survey of antimicrobial consumption and resistance in Canadian hospitals
title_full The 2017 global point prevalence survey of antimicrobial consumption and resistance in Canadian hospitals
title_fullStr The 2017 global point prevalence survey of antimicrobial consumption and resistance in Canadian hospitals
title_full_unstemmed The 2017 global point prevalence survey of antimicrobial consumption and resistance in Canadian hospitals
title_short The 2017 global point prevalence survey of antimicrobial consumption and resistance in Canadian hospitals
title_sort 2017 global point prevalence survey of antimicrobial consumption and resistance in canadian hospitals
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353732/
https://www.ncbi.nlm.nih.gov/pubmed/32653046
http://dx.doi.org/10.1186/s13756-020-00758-x
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