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Tumor Suppressors—HTRA Proteases and Interleukin-12—in Pediatric Asthma and Allergic Rhinitis Patients

Background and objective: Allergy belongs to a group of mast cell-related disorders and is one of the most common diseases of childhood. It was shown that asthma and allergic rhinitis diminish the risk of various cancers, including colon cancer and acute lymphoblastic leukemia. On the other hand, as...

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Autores principales: Renke, Joanna, Wasilewska, Eliza, Kędzierska-Mieszkowska, Sabina, Zorena, Katarzyna, Barańska, Sylwia, Wenta, Tomasz, Liberek, Anna, Siluk, Danuta, Żurawa-Janicka, Dorota, Szczepankiewicz, Aleksandra, Renke, Marcin, Lipińska, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353852/
https://www.ncbi.nlm.nih.gov/pubmed/32560402
http://dx.doi.org/10.3390/medicina56060298
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author Renke, Joanna
Wasilewska, Eliza
Kędzierska-Mieszkowska, Sabina
Zorena, Katarzyna
Barańska, Sylwia
Wenta, Tomasz
Liberek, Anna
Siluk, Danuta
Żurawa-Janicka, Dorota
Szczepankiewicz, Aleksandra
Renke, Marcin
Lipińska, Barbara
author_facet Renke, Joanna
Wasilewska, Eliza
Kędzierska-Mieszkowska, Sabina
Zorena, Katarzyna
Barańska, Sylwia
Wenta, Tomasz
Liberek, Anna
Siluk, Danuta
Żurawa-Janicka, Dorota
Szczepankiewicz, Aleksandra
Renke, Marcin
Lipińska, Barbara
author_sort Renke, Joanna
collection PubMed
description Background and objective: Allergy belongs to a group of mast cell-related disorders and is one of the most common diseases of childhood. It was shown that asthma and allergic rhinitis diminish the risk of various cancers, including colon cancer and acute lymphoblastic leukemia. On the other hand, asthma augments the risk of lung cancer and an increased risk of breast cancer in patients with allergy has been observed. Thus, the relation between allergy and cancer is not straightforward and furthermore, its biological mechanism is unknown. The HTRA (high temperature requirement A) proteases promote apoptosis, may function as tumor suppressors and HTRA1 is known to be released by mast cells. Interleukin-12 (Il-12) is an important cytokine that induces antitumor immune responses and is produced mainly by dendritic cells that co-localize with mast cells in superficial organs. Material and methods: In the present study we have assessed with ELISA plasma levels of the HTRA proteins, Il-12, and of the anti-HTRA autoantibodies in children with allergy (40) and in age matched controls (39). Children are a special population, since they usually do not have comorbidities and take not many drugs the processes we want to observe are not influenced by many other factors. Results: We have found a significant increase of HTRA1, 2 and 3, and of the Il-12 levels in the children with atopy (asthma and allergic rhinitis) compared to controls. Conclusion: Our results suggest that the HTRA1–3 and Il-12 levels might be useful in analyzing the pro- and antioncogenic potential in young atopic patients.
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spelling pubmed-73538522020-07-21 Tumor Suppressors—HTRA Proteases and Interleukin-12—in Pediatric Asthma and Allergic Rhinitis Patients Renke, Joanna Wasilewska, Eliza Kędzierska-Mieszkowska, Sabina Zorena, Katarzyna Barańska, Sylwia Wenta, Tomasz Liberek, Anna Siluk, Danuta Żurawa-Janicka, Dorota Szczepankiewicz, Aleksandra Renke, Marcin Lipińska, Barbara Medicina (Kaunas) Article Background and objective: Allergy belongs to a group of mast cell-related disorders and is one of the most common diseases of childhood. It was shown that asthma and allergic rhinitis diminish the risk of various cancers, including colon cancer and acute lymphoblastic leukemia. On the other hand, asthma augments the risk of lung cancer and an increased risk of breast cancer in patients with allergy has been observed. Thus, the relation between allergy and cancer is not straightforward and furthermore, its biological mechanism is unknown. The HTRA (high temperature requirement A) proteases promote apoptosis, may function as tumor suppressors and HTRA1 is known to be released by mast cells. Interleukin-12 (Il-12) is an important cytokine that induces antitumor immune responses and is produced mainly by dendritic cells that co-localize with mast cells in superficial organs. Material and methods: In the present study we have assessed with ELISA plasma levels of the HTRA proteins, Il-12, and of the anti-HTRA autoantibodies in children with allergy (40) and in age matched controls (39). Children are a special population, since they usually do not have comorbidities and take not many drugs the processes we want to observe are not influenced by many other factors. Results: We have found a significant increase of HTRA1, 2 and 3, and of the Il-12 levels in the children with atopy (asthma and allergic rhinitis) compared to controls. Conclusion: Our results suggest that the HTRA1–3 and Il-12 levels might be useful in analyzing the pro- and antioncogenic potential in young atopic patients. MDPI 2020-06-17 /pmc/articles/PMC7353852/ /pubmed/32560402 http://dx.doi.org/10.3390/medicina56060298 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Renke, Joanna
Wasilewska, Eliza
Kędzierska-Mieszkowska, Sabina
Zorena, Katarzyna
Barańska, Sylwia
Wenta, Tomasz
Liberek, Anna
Siluk, Danuta
Żurawa-Janicka, Dorota
Szczepankiewicz, Aleksandra
Renke, Marcin
Lipińska, Barbara
Tumor Suppressors—HTRA Proteases and Interleukin-12—in Pediatric Asthma and Allergic Rhinitis Patients
title Tumor Suppressors—HTRA Proteases and Interleukin-12—in Pediatric Asthma and Allergic Rhinitis Patients
title_full Tumor Suppressors—HTRA Proteases and Interleukin-12—in Pediatric Asthma and Allergic Rhinitis Patients
title_fullStr Tumor Suppressors—HTRA Proteases and Interleukin-12—in Pediatric Asthma and Allergic Rhinitis Patients
title_full_unstemmed Tumor Suppressors—HTRA Proteases and Interleukin-12—in Pediatric Asthma and Allergic Rhinitis Patients
title_short Tumor Suppressors—HTRA Proteases and Interleukin-12—in Pediatric Asthma and Allergic Rhinitis Patients
title_sort tumor suppressors—htra proteases and interleukin-12—in pediatric asthma and allergic rhinitis patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353852/
https://www.ncbi.nlm.nih.gov/pubmed/32560402
http://dx.doi.org/10.3390/medicina56060298
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