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Natriuretic Peptides as a Prognostic Marker for Delirium in Cardiac Surgery—A Pilot Study
Background and Objectives: Delirium is a common and major complication subsequent to cardiac surgery. Despite scientific efforts, there are no parameters which reliably predict postoperative delirium. In delirium pathology, natriuretic peptides (NPs) interfere with the blood–brain barrier and thus p...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353880/ https://www.ncbi.nlm.nih.gov/pubmed/32471143 http://dx.doi.org/10.3390/medicina56060258 |
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author | Saller, Thomas Peterss, Sven Scheiermann, Patrick Eser-Valeri, Daniela Ehler, Johannes Bruegger, Dirk Chappell, Daniel Kofler, Othmar Hagl, Christian Hofmann-Kiefer, Klaus |
author_facet | Saller, Thomas Peterss, Sven Scheiermann, Patrick Eser-Valeri, Daniela Ehler, Johannes Bruegger, Dirk Chappell, Daniel Kofler, Othmar Hagl, Christian Hofmann-Kiefer, Klaus |
author_sort | Saller, Thomas |
collection | PubMed |
description | Background and Objectives: Delirium is a common and major complication subsequent to cardiac surgery. Despite scientific efforts, there are no parameters which reliably predict postoperative delirium. In delirium pathology, natriuretic peptides (NPs) interfere with the blood–brain barrier and thus promote delirium. Therefore, we aimed to assess whether NPs may predict postoperative delirium and long-term outcomes. Materials and Methods: To evaluate the predictive value of NPs for delirium we retrospectively analyzed data from a prospective, randomized study for serum levels of atrial natriuretic peptide (ANP) and the precursor of C-type natriuretic peptide (NT-proCNP) in patients undergoing coronary artery bypass grafting (CABG) with or without cardiopulmonary bypass (off-pump coronary bypass grafting; OPCAB). Delirium was assessed by a validated chart-based method. Long-term outcomes were assessed 10 years after surgery by a telephone interview. Results: The overall incidence of delirium in the total cohort was 48% regardless of the surgical approach (CABG vs. OPCAB). Serum ANP levels > 64.6 pg/mL predicted delirium with a sensitivity (95% confidence interval) of 100% (75.3–100) and specificity of 42.9% (17.7–71.1). Serum NT-proCNP levels >1.7 pg/mL predicted delirium with a sensitivity (95% confidence interval) of 92.3% (64.0–99.8) and specificity of 42.9% (17.7–71.1). Both NPs could not predict postoperative survival or long-term cognitive decline. Conclusions: We found a positive correlation between delirium and preoperative plasma levels of ANP and NT-proCNP. A well-powered and prospective study might identify NPs as biomarkers indicating the risk of delirium and postoperative cognitive decline in patients at risk for postoperative delirium. |
format | Online Article Text |
id | pubmed-7353880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73538802020-07-21 Natriuretic Peptides as a Prognostic Marker for Delirium in Cardiac Surgery—A Pilot Study Saller, Thomas Peterss, Sven Scheiermann, Patrick Eser-Valeri, Daniela Ehler, Johannes Bruegger, Dirk Chappell, Daniel Kofler, Othmar Hagl, Christian Hofmann-Kiefer, Klaus Medicina (Kaunas) Article Background and Objectives: Delirium is a common and major complication subsequent to cardiac surgery. Despite scientific efforts, there are no parameters which reliably predict postoperative delirium. In delirium pathology, natriuretic peptides (NPs) interfere with the blood–brain barrier and thus promote delirium. Therefore, we aimed to assess whether NPs may predict postoperative delirium and long-term outcomes. Materials and Methods: To evaluate the predictive value of NPs for delirium we retrospectively analyzed data from a prospective, randomized study for serum levels of atrial natriuretic peptide (ANP) and the precursor of C-type natriuretic peptide (NT-proCNP) in patients undergoing coronary artery bypass grafting (CABG) with or without cardiopulmonary bypass (off-pump coronary bypass grafting; OPCAB). Delirium was assessed by a validated chart-based method. Long-term outcomes were assessed 10 years after surgery by a telephone interview. Results: The overall incidence of delirium in the total cohort was 48% regardless of the surgical approach (CABG vs. OPCAB). Serum ANP levels > 64.6 pg/mL predicted delirium with a sensitivity (95% confidence interval) of 100% (75.3–100) and specificity of 42.9% (17.7–71.1). Serum NT-proCNP levels >1.7 pg/mL predicted delirium with a sensitivity (95% confidence interval) of 92.3% (64.0–99.8) and specificity of 42.9% (17.7–71.1). Both NPs could not predict postoperative survival or long-term cognitive decline. Conclusions: We found a positive correlation between delirium and preoperative plasma levels of ANP and NT-proCNP. A well-powered and prospective study might identify NPs as biomarkers indicating the risk of delirium and postoperative cognitive decline in patients at risk for postoperative delirium. MDPI 2020-05-27 /pmc/articles/PMC7353880/ /pubmed/32471143 http://dx.doi.org/10.3390/medicina56060258 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Saller, Thomas Peterss, Sven Scheiermann, Patrick Eser-Valeri, Daniela Ehler, Johannes Bruegger, Dirk Chappell, Daniel Kofler, Othmar Hagl, Christian Hofmann-Kiefer, Klaus Natriuretic Peptides as a Prognostic Marker for Delirium in Cardiac Surgery—A Pilot Study |
title | Natriuretic Peptides as a Prognostic Marker for Delirium in Cardiac Surgery—A Pilot Study |
title_full | Natriuretic Peptides as a Prognostic Marker for Delirium in Cardiac Surgery—A Pilot Study |
title_fullStr | Natriuretic Peptides as a Prognostic Marker for Delirium in Cardiac Surgery—A Pilot Study |
title_full_unstemmed | Natriuretic Peptides as a Prognostic Marker for Delirium in Cardiac Surgery—A Pilot Study |
title_short | Natriuretic Peptides as a Prognostic Marker for Delirium in Cardiac Surgery—A Pilot Study |
title_sort | natriuretic peptides as a prognostic marker for delirium in cardiac surgery—a pilot study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353880/ https://www.ncbi.nlm.nih.gov/pubmed/32471143 http://dx.doi.org/10.3390/medicina56060258 |
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