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Association between Osteoporosis and Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke

Background and objectives: Little is known about the effect of osteoporosis on cognitive function in the acute and recovery phases of stroke. Early bone mineral density assessments during acute stroke may be a useful marker of cognitive function. We evaluated the effect of osteoporosis on cognitive...

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Autores principales: Lee, Sang-Hwa, Park, So Young, Jang, Min Uk, Kim, Yerim, Lee, Jungyoup, Kim, Chulho, Kim, Yeo Jin, Sohn, Jong-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353884/
https://www.ncbi.nlm.nih.gov/pubmed/32585806
http://dx.doi.org/10.3390/medicina56060307
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author Lee, Sang-Hwa
Park, So Young
Jang, Min Uk
Kim, Yerim
Lee, Jungyoup
Kim, Chulho
Kim, Yeo Jin
Sohn, Jong-Hee
author_facet Lee, Sang-Hwa
Park, So Young
Jang, Min Uk
Kim, Yerim
Lee, Jungyoup
Kim, Chulho
Kim, Yeo Jin
Sohn, Jong-Hee
author_sort Lee, Sang-Hwa
collection PubMed
description Background and objectives: Little is known about the effect of osteoporosis on cognitive function in the acute and recovery phases of stroke. Early bone mineral density assessments during acute stroke may be a useful marker of cognitive function. We evaluated the effect of osteoporosis on cognitive function at the early and recovery phase of ischemic stroke in patients aged >50 years. Materials and Methods: We retrospectively examined consecutive patients with acute stroke hospitalized between 2016 and 2018. Osteoporosis was defined as a T-score <–2.5 for the femoral neck or lumbar spine bone mineral density. The primary outcome was cognitive impairment measured by the Korean Mini-Mental State Examination in the acute phase and recovery phase of ischemic stroke. Results: Of the 260 included subjects (107 men and 153 women), 70 (26.9%) had osteoporosis. Cognitive impairment was more severe in the osteoporosis group than in the non-osteoporosis group (30.5% versus 47.1%, p = 0.001). After the recovery phase of stroke, the proportion of patients with cognitive impairment remained higher in the osteoporosis group. The multivariate analysis revealed a correlation between a low femoral neck bone mineral density and severe cognitive impairment in the acute and recovery phases of stroke (adjusted odds ratio (OR) 4.09, 95% confidence interval (CI) 1.11–15.14 in the acute phase, and adjusted OR 11.17, 95% CI 1.12–110.98 in the recovery phase). Conclusions: Low bone mineral density is associated with poor cognitive function in the acute and recovery phases of stroke.
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spelling pubmed-73538842020-07-21 Association between Osteoporosis and Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke Lee, Sang-Hwa Park, So Young Jang, Min Uk Kim, Yerim Lee, Jungyoup Kim, Chulho Kim, Yeo Jin Sohn, Jong-Hee Medicina (Kaunas) Article Background and objectives: Little is known about the effect of osteoporosis on cognitive function in the acute and recovery phases of stroke. Early bone mineral density assessments during acute stroke may be a useful marker of cognitive function. We evaluated the effect of osteoporosis on cognitive function at the early and recovery phase of ischemic stroke in patients aged >50 years. Materials and Methods: We retrospectively examined consecutive patients with acute stroke hospitalized between 2016 and 2018. Osteoporosis was defined as a T-score <–2.5 for the femoral neck or lumbar spine bone mineral density. The primary outcome was cognitive impairment measured by the Korean Mini-Mental State Examination in the acute phase and recovery phase of ischemic stroke. Results: Of the 260 included subjects (107 men and 153 women), 70 (26.9%) had osteoporosis. Cognitive impairment was more severe in the osteoporosis group than in the non-osteoporosis group (30.5% versus 47.1%, p = 0.001). After the recovery phase of stroke, the proportion of patients with cognitive impairment remained higher in the osteoporosis group. The multivariate analysis revealed a correlation between a low femoral neck bone mineral density and severe cognitive impairment in the acute and recovery phases of stroke (adjusted odds ratio (OR) 4.09, 95% confidence interval (CI) 1.11–15.14 in the acute phase, and adjusted OR 11.17, 95% CI 1.12–110.98 in the recovery phase). Conclusions: Low bone mineral density is associated with poor cognitive function in the acute and recovery phases of stroke. MDPI 2020-06-23 /pmc/articles/PMC7353884/ /pubmed/32585806 http://dx.doi.org/10.3390/medicina56060307 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Sang-Hwa
Park, So Young
Jang, Min Uk
Kim, Yerim
Lee, Jungyoup
Kim, Chulho
Kim, Yeo Jin
Sohn, Jong-Hee
Association between Osteoporosis and Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke
title Association between Osteoporosis and Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke
title_full Association between Osteoporosis and Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke
title_fullStr Association between Osteoporosis and Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke
title_full_unstemmed Association between Osteoporosis and Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke
title_short Association between Osteoporosis and Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke
title_sort association between osteoporosis and cognitive impairment during the acute and recovery phases of ischemic stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353884/
https://www.ncbi.nlm.nih.gov/pubmed/32585806
http://dx.doi.org/10.3390/medicina56060307
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