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Association between Osteoporosis and Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke
Background and objectives: Little is known about the effect of osteoporosis on cognitive function in the acute and recovery phases of stroke. Early bone mineral density assessments during acute stroke may be a useful marker of cognitive function. We evaluated the effect of osteoporosis on cognitive...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353884/ https://www.ncbi.nlm.nih.gov/pubmed/32585806 http://dx.doi.org/10.3390/medicina56060307 |
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author | Lee, Sang-Hwa Park, So Young Jang, Min Uk Kim, Yerim Lee, Jungyoup Kim, Chulho Kim, Yeo Jin Sohn, Jong-Hee |
author_facet | Lee, Sang-Hwa Park, So Young Jang, Min Uk Kim, Yerim Lee, Jungyoup Kim, Chulho Kim, Yeo Jin Sohn, Jong-Hee |
author_sort | Lee, Sang-Hwa |
collection | PubMed |
description | Background and objectives: Little is known about the effect of osteoporosis on cognitive function in the acute and recovery phases of stroke. Early bone mineral density assessments during acute stroke may be a useful marker of cognitive function. We evaluated the effect of osteoporosis on cognitive function at the early and recovery phase of ischemic stroke in patients aged >50 years. Materials and Methods: We retrospectively examined consecutive patients with acute stroke hospitalized between 2016 and 2018. Osteoporosis was defined as a T-score <–2.5 for the femoral neck or lumbar spine bone mineral density. The primary outcome was cognitive impairment measured by the Korean Mini-Mental State Examination in the acute phase and recovery phase of ischemic stroke. Results: Of the 260 included subjects (107 men and 153 women), 70 (26.9%) had osteoporosis. Cognitive impairment was more severe in the osteoporosis group than in the non-osteoporosis group (30.5% versus 47.1%, p = 0.001). After the recovery phase of stroke, the proportion of patients with cognitive impairment remained higher in the osteoporosis group. The multivariate analysis revealed a correlation between a low femoral neck bone mineral density and severe cognitive impairment in the acute and recovery phases of stroke (adjusted odds ratio (OR) 4.09, 95% confidence interval (CI) 1.11–15.14 in the acute phase, and adjusted OR 11.17, 95% CI 1.12–110.98 in the recovery phase). Conclusions: Low bone mineral density is associated with poor cognitive function in the acute and recovery phases of stroke. |
format | Online Article Text |
id | pubmed-7353884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73538842020-07-21 Association between Osteoporosis and Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke Lee, Sang-Hwa Park, So Young Jang, Min Uk Kim, Yerim Lee, Jungyoup Kim, Chulho Kim, Yeo Jin Sohn, Jong-Hee Medicina (Kaunas) Article Background and objectives: Little is known about the effect of osteoporosis on cognitive function in the acute and recovery phases of stroke. Early bone mineral density assessments during acute stroke may be a useful marker of cognitive function. We evaluated the effect of osteoporosis on cognitive function at the early and recovery phase of ischemic stroke in patients aged >50 years. Materials and Methods: We retrospectively examined consecutive patients with acute stroke hospitalized between 2016 and 2018. Osteoporosis was defined as a T-score <–2.5 for the femoral neck or lumbar spine bone mineral density. The primary outcome was cognitive impairment measured by the Korean Mini-Mental State Examination in the acute phase and recovery phase of ischemic stroke. Results: Of the 260 included subjects (107 men and 153 women), 70 (26.9%) had osteoporosis. Cognitive impairment was more severe in the osteoporosis group than in the non-osteoporosis group (30.5% versus 47.1%, p = 0.001). After the recovery phase of stroke, the proportion of patients with cognitive impairment remained higher in the osteoporosis group. The multivariate analysis revealed a correlation between a low femoral neck bone mineral density and severe cognitive impairment in the acute and recovery phases of stroke (adjusted odds ratio (OR) 4.09, 95% confidence interval (CI) 1.11–15.14 in the acute phase, and adjusted OR 11.17, 95% CI 1.12–110.98 in the recovery phase). Conclusions: Low bone mineral density is associated with poor cognitive function in the acute and recovery phases of stroke. MDPI 2020-06-23 /pmc/articles/PMC7353884/ /pubmed/32585806 http://dx.doi.org/10.3390/medicina56060307 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Sang-Hwa Park, So Young Jang, Min Uk Kim, Yerim Lee, Jungyoup Kim, Chulho Kim, Yeo Jin Sohn, Jong-Hee Association between Osteoporosis and Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke |
title | Association between Osteoporosis and Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke |
title_full | Association between Osteoporosis and Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke |
title_fullStr | Association between Osteoporosis and Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke |
title_full_unstemmed | Association between Osteoporosis and Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke |
title_short | Association between Osteoporosis and Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke |
title_sort | association between osteoporosis and cognitive impairment during the acute and recovery phases of ischemic stroke |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353884/ https://www.ncbi.nlm.nih.gov/pubmed/32585806 http://dx.doi.org/10.3390/medicina56060307 |
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