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Penetrance of Breast and Ovarian Cancer in Women Who Carry a BRCA1/2 Mutation and Do Not Use Risk-Reducing Salpingo-Oophorectomy: An Updated Meta-Analysis

BACKGROUND: Use of risk-reducing Salpingo-oophorectomy (RRSO) substantially reduces the risk of ovarian and breast cancer for women who carry a BRCA1/2 mutation. It is important to adjust for RRSO use in the estimation of BRCA1/2 penetrance of breast and ovarian cancer. METHODS: We searched PubMed f...

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Detalles Bibliográficos
Autores principales: Chen, Jinbo, Bae, Eunchan, Zhang, Lingjiao, Hughes, Kevin, Parmigiani, Giovanni, Braun, Danielle, Rebbeck, Timothy R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353955/
https://www.ncbi.nlm.nih.gov/pubmed/32676552
http://dx.doi.org/10.1093/jncics/pkaa029