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Androgen Receptor Expression and Its Correlation with Clinicopathological Parameters in Iranian Patients with Triple Negative Breast Cancer

BACKGROUND & OBJECTIVE: Our knowledge about correlation of androgen receptor expression and clinicopathological properties of triple-negative breast cancer (TNBC) patients is inadequate, particularly in the Iranian population. The main aim of the present study was to assess the AR expression in...

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Autores principales: Naimi, Azar, Soltan, Maryam, Amjadi, Elham, Goli, Parvin, Kefayat, Amirhosein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society of Pathology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354074/
https://www.ncbi.nlm.nih.gov/pubmed/32754220
http://dx.doi.org/10.30699/ijp.2020.112819.2224
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author Naimi, Azar
Soltan, Maryam
Amjadi, Elham
Goli, Parvin
Kefayat, Amirhosein
author_facet Naimi, Azar
Soltan, Maryam
Amjadi, Elham
Goli, Parvin
Kefayat, Amirhosein
author_sort Naimi, Azar
collection PubMed
description BACKGROUND & OBJECTIVE: Our knowledge about correlation of androgen receptor expression and clinicopathological properties of triple-negative breast cancer (TNBC) patients is inadequate, particularly in the Iranian population. The main aim of the present study was to assess the AR expression in TNBC Iranian patients and evaluate its correlation with their clinicopathological parameters. METHODS: Herein, 76 TNBC patients were evaluated for the AR expression by immunohistochemistry. The slides' staining intensity was investigated according to the average degree of nuclear staining and sub-classified into negative (0), weak (1), moderate (2), or strong (3). Subsequently, the positive cells percentage for each slide was assessed and sub-classified into <25% (1), 25-50% (2), 50-75% (3), and >75% (4). The aggregation of these two scores was used as the final score ranging from 0 to 7. While 4-7 scores were selected as positive, the others were included in the AR-negative expression group. Fisher's exact test was used to analyze the AR expression correlation with the clinicopathological parameters. RESULTS: Positive immunoreactivity for AR was observed in 8 out of 76 (11%) specimens. No-correlation (P>0.05) was observed between the AR expression and grade, stage, lymph node status, and Ki-67 level. The AR-positive patients exhibited older age at the time of diagnosis (P=0.0339) and larger tumor size (P=0.0224) in comparison with the AR-negative patients. Low percentage of TNBC patients expressed AR and no significant correlation was observed between its expression and most of the clinicopathological parameters. CONCLUSION: AR may not be a suitable biomarker and treatment target for the Iranian patients with TNBC.
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spelling pubmed-73540742020-08-03 Androgen Receptor Expression and Its Correlation with Clinicopathological Parameters in Iranian Patients with Triple Negative Breast Cancer Naimi, Azar Soltan, Maryam Amjadi, Elham Goli, Parvin Kefayat, Amirhosein Iran J Pathol Original Article BACKGROUND & OBJECTIVE: Our knowledge about correlation of androgen receptor expression and clinicopathological properties of triple-negative breast cancer (TNBC) patients is inadequate, particularly in the Iranian population. The main aim of the present study was to assess the AR expression in TNBC Iranian patients and evaluate its correlation with their clinicopathological parameters. METHODS: Herein, 76 TNBC patients were evaluated for the AR expression by immunohistochemistry. The slides' staining intensity was investigated according to the average degree of nuclear staining and sub-classified into negative (0), weak (1), moderate (2), or strong (3). Subsequently, the positive cells percentage for each slide was assessed and sub-classified into <25% (1), 25-50% (2), 50-75% (3), and >75% (4). The aggregation of these two scores was used as the final score ranging from 0 to 7. While 4-7 scores were selected as positive, the others were included in the AR-negative expression group. Fisher's exact test was used to analyze the AR expression correlation with the clinicopathological parameters. RESULTS: Positive immunoreactivity for AR was observed in 8 out of 76 (11%) specimens. No-correlation (P>0.05) was observed between the AR expression and grade, stage, lymph node status, and Ki-67 level. The AR-positive patients exhibited older age at the time of diagnosis (P=0.0339) and larger tumor size (P=0.0224) in comparison with the AR-negative patients. Low percentage of TNBC patients expressed AR and no significant correlation was observed between its expression and most of the clinicopathological parameters. CONCLUSION: AR may not be a suitable biomarker and treatment target for the Iranian patients with TNBC. Iranian Society of Pathology 2020 2020-05-08 /pmc/articles/PMC7354074/ /pubmed/32754220 http://dx.doi.org/10.30699/ijp.2020.112819.2224 Text en This is an open-access article distributed under the terms of the Creative Commons Attribution-noncommercial 4.0 International License, (https://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Original Article
Naimi, Azar
Soltan, Maryam
Amjadi, Elham
Goli, Parvin
Kefayat, Amirhosein
Androgen Receptor Expression and Its Correlation with Clinicopathological Parameters in Iranian Patients with Triple Negative Breast Cancer
title Androgen Receptor Expression and Its Correlation with Clinicopathological Parameters in Iranian Patients with Triple Negative Breast Cancer
title_full Androgen Receptor Expression and Its Correlation with Clinicopathological Parameters in Iranian Patients with Triple Negative Breast Cancer
title_fullStr Androgen Receptor Expression and Its Correlation with Clinicopathological Parameters in Iranian Patients with Triple Negative Breast Cancer
title_full_unstemmed Androgen Receptor Expression and Its Correlation with Clinicopathological Parameters in Iranian Patients with Triple Negative Breast Cancer
title_short Androgen Receptor Expression and Its Correlation with Clinicopathological Parameters in Iranian Patients with Triple Negative Breast Cancer
title_sort androgen receptor expression and its correlation with clinicopathological parameters in iranian patients with triple negative breast cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354074/
https://www.ncbi.nlm.nih.gov/pubmed/32754220
http://dx.doi.org/10.30699/ijp.2020.112819.2224
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