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Impact of interval walking training managed through smart mobile devices on albuminuria and leptin/adiponectin ratio in patients with type 2 diabetes

BACKGROUND: Interval walking training has demonstrated more pronounced positive effects on physical fitness and metabolism in type 2 diabetes (T2D), compared to continuous walking. One of the pathogenic mechanisms of T2D is associated with derangements in leptin/adiponectin axis, which might predisp...

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Autores principales: Sokolovska, Jelizaveta, Ostrovska, Karina, Pahirko, Leonora, Varblane, Gunita, Krilatiha, Ksenija, Cirulnieks, Austris, Folkmane, Inese, Pirags, Valdis, Valeinis, Janis, Klavina, Aija, Selavo, Leo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354089/
https://www.ncbi.nlm.nih.gov/pubmed/32652863
http://dx.doi.org/10.14814/phy2.14506
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author Sokolovska, Jelizaveta
Ostrovska, Karina
Pahirko, Leonora
Varblane, Gunita
Krilatiha, Ksenija
Cirulnieks, Austris
Folkmane, Inese
Pirags, Valdis
Valeinis, Janis
Klavina, Aija
Selavo, Leo
author_facet Sokolovska, Jelizaveta
Ostrovska, Karina
Pahirko, Leonora
Varblane, Gunita
Krilatiha, Ksenija
Cirulnieks, Austris
Folkmane, Inese
Pirags, Valdis
Valeinis, Janis
Klavina, Aija
Selavo, Leo
author_sort Sokolovska, Jelizaveta
collection PubMed
description BACKGROUND: Interval walking training has demonstrated more pronounced positive effects on physical fitness and metabolism in type 2 diabetes (T2D), compared to continuous walking. One of the pathogenic mechanisms of T2D is associated with derangements in leptin/adiponectin axis, which might predispose affected individuals to vascular inflammation and albuminuria. The aim of this study was to investigate the effects of interval walking training delivered through smart mobile devices upon albuminuria and leptin/adiponectin ratio in patients with T2D. METHODS: Patients with T2D aged 35–75 were randomized into control (n = 26) and interval training (IT, n = 14) groups. Patients in IT group had to perform three 60‐min interval walking sessions (3 min intervals of slow and fast walking with the intensity of 40% and 70% of the peak energy expenditure) per week delivered by smartphone application for four months. The adherence to training was monitored remotely. Outcome measures were albuminuria, leptin/adiponectin ratio, obesity indicators, and glycaemic control. Leptin and adiponectin concentration was measured in serum samples by Luminex technology. RESULTS: In the IT group compared to control group, we observed a statistically significant decrease in albuminuria (p = .002) and leptin/adiponectin ratio (p = .01), as well as a decrease in HbA1c close to statistical significance (p = .09). In IT group, changes in leptin/adiponectin ratio correlated significantly with changes in hip circumference (p = .024). CONCLUSION: Interval walking training is beneficial for vascular health in T2D via impact on albuminuria and leptin/adiponectin ratio.
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spelling pubmed-73540892020-07-17 Impact of interval walking training managed through smart mobile devices on albuminuria and leptin/adiponectin ratio in patients with type 2 diabetes Sokolovska, Jelizaveta Ostrovska, Karina Pahirko, Leonora Varblane, Gunita Krilatiha, Ksenija Cirulnieks, Austris Folkmane, Inese Pirags, Valdis Valeinis, Janis Klavina, Aija Selavo, Leo Physiol Rep Original Articles BACKGROUND: Interval walking training has demonstrated more pronounced positive effects on physical fitness and metabolism in type 2 diabetes (T2D), compared to continuous walking. One of the pathogenic mechanisms of T2D is associated with derangements in leptin/adiponectin axis, which might predispose affected individuals to vascular inflammation and albuminuria. The aim of this study was to investigate the effects of interval walking training delivered through smart mobile devices upon albuminuria and leptin/adiponectin ratio in patients with T2D. METHODS: Patients with T2D aged 35–75 were randomized into control (n = 26) and interval training (IT, n = 14) groups. Patients in IT group had to perform three 60‐min interval walking sessions (3 min intervals of slow and fast walking with the intensity of 40% and 70% of the peak energy expenditure) per week delivered by smartphone application for four months. The adherence to training was monitored remotely. Outcome measures were albuminuria, leptin/adiponectin ratio, obesity indicators, and glycaemic control. Leptin and adiponectin concentration was measured in serum samples by Luminex technology. RESULTS: In the IT group compared to control group, we observed a statistically significant decrease in albuminuria (p = .002) and leptin/adiponectin ratio (p = .01), as well as a decrease in HbA1c close to statistical significance (p = .09). In IT group, changes in leptin/adiponectin ratio correlated significantly with changes in hip circumference (p = .024). CONCLUSION: Interval walking training is beneficial for vascular health in T2D via impact on albuminuria and leptin/adiponectin ratio. John Wiley and Sons Inc. 2020-07-11 /pmc/articles/PMC7354089/ /pubmed/32652863 http://dx.doi.org/10.14814/phy2.14506 Text en © 2020 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Sokolovska, Jelizaveta
Ostrovska, Karina
Pahirko, Leonora
Varblane, Gunita
Krilatiha, Ksenija
Cirulnieks, Austris
Folkmane, Inese
Pirags, Valdis
Valeinis, Janis
Klavina, Aija
Selavo, Leo
Impact of interval walking training managed through smart mobile devices on albuminuria and leptin/adiponectin ratio in patients with type 2 diabetes
title Impact of interval walking training managed through smart mobile devices on albuminuria and leptin/adiponectin ratio in patients with type 2 diabetes
title_full Impact of interval walking training managed through smart mobile devices on albuminuria and leptin/adiponectin ratio in patients with type 2 diabetes
title_fullStr Impact of interval walking training managed through smart mobile devices on albuminuria and leptin/adiponectin ratio in patients with type 2 diabetes
title_full_unstemmed Impact of interval walking training managed through smart mobile devices on albuminuria and leptin/adiponectin ratio in patients with type 2 diabetes
title_short Impact of interval walking training managed through smart mobile devices on albuminuria and leptin/adiponectin ratio in patients with type 2 diabetes
title_sort impact of interval walking training managed through smart mobile devices on albuminuria and leptin/adiponectin ratio in patients with type 2 diabetes
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354089/
https://www.ncbi.nlm.nih.gov/pubmed/32652863
http://dx.doi.org/10.14814/phy2.14506
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