Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel

Cyclic nucleotide-gated (CNG) channels convert cyclic nucleotide binding and unbinding into electrical signals in sensory receptors and neurons. The molecular conformational changes underpinning ligand activation are largely undefined. We report both closed- and open-state atomic cryo-EM structures...

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Detalles Bibliográficos
Autores principales: Zheng, Xiangdong, Fu, Ziao, Su, Deyuan, Zhang, Yuebin, Li, Minghui, Pan, Yaping, Li, Huan, Li, Shufang, Grassucci, Robert A., Ren, Zhenning, Hu, Zhengshan, Li, Xueming, Zhou, Ming, Li, Guohui, Frank, Joachim, Yang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354226/
https://www.ncbi.nlm.nih.gov/pubmed/32483338
http://dx.doi.org/10.1038/s41594-020-0433-5

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