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Gene-environment interaction with smoking for increased non-muscle-invasive bladder cancer tumor size
BACKGROUND: Urinary bladder cancer (UBC) is one of few cancers with an established gene-environment interaction (GxE) with smoking. However, it is unknown whether the interaction with tobacco use is present non-muscle invasive bladder cancer (NMIBC) and characteristics of prognostic relevance. We ai...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354298/ https://www.ncbi.nlm.nih.gov/pubmed/32676417 http://dx.doi.org/10.21037/tau-19-523 |
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author | Lipunova, Nadezda Wesselius, Anke Cheng, Kar K. van Schooten, Frederik-Jan Bryan, Richard T. Cazier, Jean-Baptiste Zeegers, Maurice P. |
author_facet | Lipunova, Nadezda Wesselius, Anke Cheng, Kar K. van Schooten, Frederik-Jan Bryan, Richard T. Cazier, Jean-Baptiste Zeegers, Maurice P. |
author_sort | Lipunova, Nadezda |
collection | PubMed |
description | BACKGROUND: Urinary bladder cancer (UBC) is one of few cancers with an established gene-environment interaction (GxE) with smoking. However, it is unknown whether the interaction with tobacco use is present non-muscle invasive bladder cancer (NMIBC) and characteristics of prognostic relevance. We aimed to investigate if smoking status and/or smoking intensity interact with the effect of discovered variants on key NMIBC characteristics of tumor grade, stage, size, and patient age within the Bladder Cancer Prognosis Programme (BCPP) cohort. METHODS: Analyzed sample consisted of 546 NMIBC patients with valid smoking data from the BCPP. In a previous genome-wide association study (GWAS), we have identified 61 single nucleotide polymorphisms (SNPs) potentially associated with the NMIBC characteristics of tumor stage, grade, size, and patient age. In the current analysis, we have tested these SNPs for GxE with smoking. RESULTS: Out of 61 SNPs, 10 have showed suggestion (statistical significance level of P<0.05) for GxE with NMIBC tumor size rs35225990, rs188958632, rs180910528, rs74603364, rs187040828, rs144383242, rs117587674, rs113705641, rs2937268, and chromosome 14:38247577. All SNPs were located across loci of 1p31.3, 3p26.1, 6q14.1, 14q21.1, and 13q14.13. In addition, two of the tested polymorphisms were suggestive for interaction with smoking intensity (chromosome 14:38247577 and rs2937268). CONCLUSIONS: Our study suggests interaction between genetic variance and smoking behavior for increased NMIBC tumor size at the time of diagnosis. Further replication is required to validate these findings. |
format | Online Article Text |
id | pubmed-7354298 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-73542982020-07-15 Gene-environment interaction with smoking for increased non-muscle-invasive bladder cancer tumor size Lipunova, Nadezda Wesselius, Anke Cheng, Kar K. van Schooten, Frederik-Jan Bryan, Richard T. Cazier, Jean-Baptiste Zeegers, Maurice P. Transl Androl Urol Original Article BACKGROUND: Urinary bladder cancer (UBC) is one of few cancers with an established gene-environment interaction (GxE) with smoking. However, it is unknown whether the interaction with tobacco use is present non-muscle invasive bladder cancer (NMIBC) and characteristics of prognostic relevance. We aimed to investigate if smoking status and/or smoking intensity interact with the effect of discovered variants on key NMIBC characteristics of tumor grade, stage, size, and patient age within the Bladder Cancer Prognosis Programme (BCPP) cohort. METHODS: Analyzed sample consisted of 546 NMIBC patients with valid smoking data from the BCPP. In a previous genome-wide association study (GWAS), we have identified 61 single nucleotide polymorphisms (SNPs) potentially associated with the NMIBC characteristics of tumor stage, grade, size, and patient age. In the current analysis, we have tested these SNPs for GxE with smoking. RESULTS: Out of 61 SNPs, 10 have showed suggestion (statistical significance level of P<0.05) for GxE with NMIBC tumor size rs35225990, rs188958632, rs180910528, rs74603364, rs187040828, rs144383242, rs117587674, rs113705641, rs2937268, and chromosome 14:38247577. All SNPs were located across loci of 1p31.3, 3p26.1, 6q14.1, 14q21.1, and 13q14.13. In addition, two of the tested polymorphisms were suggestive for interaction with smoking intensity (chromosome 14:38247577 and rs2937268). CONCLUSIONS: Our study suggests interaction between genetic variance and smoking behavior for increased NMIBC tumor size at the time of diagnosis. Further replication is required to validate these findings. AME Publishing Company 2020-06 /pmc/articles/PMC7354298/ /pubmed/32676417 http://dx.doi.org/10.21037/tau-19-523 Text en 2020 Translational Andrology and Urology. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Lipunova, Nadezda Wesselius, Anke Cheng, Kar K. van Schooten, Frederik-Jan Bryan, Richard T. Cazier, Jean-Baptiste Zeegers, Maurice P. Gene-environment interaction with smoking for increased non-muscle-invasive bladder cancer tumor size |
title | Gene-environment interaction with smoking for increased non-muscle-invasive bladder cancer tumor size |
title_full | Gene-environment interaction with smoking for increased non-muscle-invasive bladder cancer tumor size |
title_fullStr | Gene-environment interaction with smoking for increased non-muscle-invasive bladder cancer tumor size |
title_full_unstemmed | Gene-environment interaction with smoking for increased non-muscle-invasive bladder cancer tumor size |
title_short | Gene-environment interaction with smoking for increased non-muscle-invasive bladder cancer tumor size |
title_sort | gene-environment interaction with smoking for increased non-muscle-invasive bladder cancer tumor size |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354298/ https://www.ncbi.nlm.nih.gov/pubmed/32676417 http://dx.doi.org/10.21037/tau-19-523 |
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