A single-centre experience of intravenous thrombolysis for stroke in COVID-19 patients

The sudden worldwide outbreak of Coronavirus Disease 2019 (COVID-19) has certainly provided new challenges in the management of acute ischaemic stroke, and the risk-benefit ratio of intravenous thrombolysis in COVID-19 positive patients is not well known. We describe four COVID-19 patients treated w...

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Autores principales: Sangalli, Davide, Polonia, Valeria, Colombo, Daniele, Mantero, Vittorio, Filizzolo, Marco, Scaccabarozzi, Chiara, Salmaggi, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Covid-19
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354364/
https://www.ncbi.nlm.nih.gov/pubmed/32656711
http://dx.doi.org/10.1007/s10072-020-04591-3
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author Sangalli, Davide
Polonia, Valeria
Colombo, Daniele
Mantero, Vittorio
Filizzolo, Marco
Scaccabarozzi, Chiara
Salmaggi, Andrea
author_facet Sangalli, Davide
Polonia, Valeria
Colombo, Daniele
Mantero, Vittorio
Filizzolo, Marco
Scaccabarozzi, Chiara
Salmaggi, Andrea
author_sort Sangalli, Davide
collection PubMed
description The sudden worldwide outbreak of Coronavirus Disease 2019 (COVID-19) has certainly provided new challenges in the management of acute ischaemic stroke, and the risk-benefit ratio of intravenous thrombolysis in COVID-19 positive patients is not well known. We describe four COVID-19 patients treated with intravenous thrombolysis for acute ischaemic stroke. Although rt-PA administration is the main therapeutic strategy, our patients experienced unpredictable complications and showed atypical features: the overall mortality was very high. In conclusion, in this article, we provide information about these cases and discuss the possible explanation behind this trend.
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spelling pubmed-73543642020-07-13 A single-centre experience of intravenous thrombolysis for stroke in COVID-19 patients Sangalli, Davide Polonia, Valeria Colombo, Daniele Mantero, Vittorio Filizzolo, Marco Scaccabarozzi, Chiara Salmaggi, Andrea Neurol Sci Covid-19 The sudden worldwide outbreak of Coronavirus Disease 2019 (COVID-19) has certainly provided new challenges in the management of acute ischaemic stroke, and the risk-benefit ratio of intravenous thrombolysis in COVID-19 positive patients is not well known. We describe four COVID-19 patients treated with intravenous thrombolysis for acute ischaemic stroke. Although rt-PA administration is the main therapeutic strategy, our patients experienced unpredictable complications and showed atypical features: the overall mortality was very high. In conclusion, in this article, we provide information about these cases and discuss the possible explanation behind this trend. Springer International Publishing 2020-07-12 2020 /pmc/articles/PMC7354364/ /pubmed/32656711 http://dx.doi.org/10.1007/s10072-020-04591-3 Text en © Fondazione Società Italiana di Neurologia 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Covid-19
Sangalli, Davide
Polonia, Valeria
Colombo, Daniele
Mantero, Vittorio
Filizzolo, Marco
Scaccabarozzi, Chiara
Salmaggi, Andrea
A single-centre experience of intravenous thrombolysis for stroke in COVID-19 patients
title A single-centre experience of intravenous thrombolysis for stroke in COVID-19 patients
title_full A single-centre experience of intravenous thrombolysis for stroke in COVID-19 patients
title_fullStr A single-centre experience of intravenous thrombolysis for stroke in COVID-19 patients
title_full_unstemmed A single-centre experience of intravenous thrombolysis for stroke in COVID-19 patients
title_short A single-centre experience of intravenous thrombolysis for stroke in COVID-19 patients
title_sort single-centre experience of intravenous thrombolysis for stroke in covid-19 patients
topic Covid-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354364/
https://www.ncbi.nlm.nih.gov/pubmed/32656711
http://dx.doi.org/10.1007/s10072-020-04591-3
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