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An illustrated review of bleeding assessment tools and common coagulation tests

Recognizing the complexity of coagulation tests and currently used anticoagulants, we developed this illustrated review on bleeding assessment tools and common coagulation screening tests. Quantitative bleeding assessment tools (BATs) are available to standardize the bleeding history and improve the...

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Detalles Bibliográficos
Autores principales: Elbaz, Carolyne, Sholzberg, Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354401/
https://www.ncbi.nlm.nih.gov/pubmed/32685885
http://dx.doi.org/10.1002/rth2.12339
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author Elbaz, Carolyne
Sholzberg, Michelle
author_facet Elbaz, Carolyne
Sholzberg, Michelle
author_sort Elbaz, Carolyne
collection PubMed
description Recognizing the complexity of coagulation tests and currently used anticoagulants, we developed this illustrated review on bleeding assessment tools and common coagulation screening tests. Quantitative bleeding assessment tools (BATs) are available to standardize the bleeding history and improve the pretest probability prior to coagulation testing. We describe use of BATs and the principles, indications, and limitations of the prothrombin time (PT)/International Normalized Ratio, activated partial thromboplastin time (APTT), and 50:50 mix. Use of these tests to identify coagulation factor deficiencies, specific and nonspecific inhibitors, coagulopathy of liver disease, disseminated intravascular coagulation, and commonly used anticoagulant medications are reviewed. Current literature suggests that unnecessary coagulation testing is rampant. The PT and APTT have astoundingly low sensitivity (1.0%‐2.1%) for detection of clinically significant bleeding disorders. Thus, current guidelines recommend against the use of screening PT and APTT in preoperative patients undergoing noncardiac/vascular surgery.
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spelling pubmed-73544012020-07-17 An illustrated review of bleeding assessment tools and common coagulation tests Elbaz, Carolyne Sholzberg, Michelle Res Pract Thromb Haemost Illustrated Review Recognizing the complexity of coagulation tests and currently used anticoagulants, we developed this illustrated review on bleeding assessment tools and common coagulation screening tests. Quantitative bleeding assessment tools (BATs) are available to standardize the bleeding history and improve the pretest probability prior to coagulation testing. We describe use of BATs and the principles, indications, and limitations of the prothrombin time (PT)/International Normalized Ratio, activated partial thromboplastin time (APTT), and 50:50 mix. Use of these tests to identify coagulation factor deficiencies, specific and nonspecific inhibitors, coagulopathy of liver disease, disseminated intravascular coagulation, and commonly used anticoagulant medications are reviewed. Current literature suggests that unnecessary coagulation testing is rampant. The PT and APTT have astoundingly low sensitivity (1.0%‐2.1%) for detection of clinically significant bleeding disorders. Thus, current guidelines recommend against the use of screening PT and APTT in preoperative patients undergoing noncardiac/vascular surgery. John Wiley and Sons Inc. 2020-07-06 /pmc/articles/PMC7354401/ /pubmed/32685885 http://dx.doi.org/10.1002/rth2.12339 Text en © 2020 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Illustrated Review
Elbaz, Carolyne
Sholzberg, Michelle
An illustrated review of bleeding assessment tools and common coagulation tests
title An illustrated review of bleeding assessment tools and common coagulation tests
title_full An illustrated review of bleeding assessment tools and common coagulation tests
title_fullStr An illustrated review of bleeding assessment tools and common coagulation tests
title_full_unstemmed An illustrated review of bleeding assessment tools and common coagulation tests
title_short An illustrated review of bleeding assessment tools and common coagulation tests
title_sort illustrated review of bleeding assessment tools and common coagulation tests
topic Illustrated Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354401/
https://www.ncbi.nlm.nih.gov/pubmed/32685885
http://dx.doi.org/10.1002/rth2.12339
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