Thrombosis and coagulopathy in COVID‐19: An illustrated review

This illustrated review discusses the haemostatic changes seen in patients with severe coronavirus disease 2019 (COVID‐19) infection and their possible causes. We discuss the crosstalk between inflammation and coagulation resulting in high levels of acute‐phase proteins, very high levels of D‐dimers...

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Detalles Bibliográficos
Autores principales: Levi, Marcel, Hunt, Beverley J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Illustrated Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354416/
https://www.ncbi.nlm.nih.gov/pubmed/32685883
http://dx.doi.org/10.1002/rth2.12400
Descripción
Sumario:This illustrated review discusses the haemostatic changes seen in patients with severe coronavirus disease 2019 (COVID‐19) infection and their possible causes. We discuss the crosstalk between inflammation and coagulation resulting in high levels of acute‐phase proteins, very high levels of D‐dimers, and absence of disseminated intravascular coagulation seen in patients with severe COVID‐19. There appear to be high rates of venous thromboembolism and also, what has been poorly described before in acute lung injury, a high rate of pulmonary immunothrombosis (thrombosis secondary to inflammation).

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