Thrombosis and coagulopathy in COVID‐19: An illustrated review

This illustrated review discusses the haemostatic changes seen in patients with severe coronavirus disease 2019 (COVID‐19) infection and their possible causes. We discuss the crosstalk between inflammation and coagulation resulting in high levels of acute‐phase proteins, very high levels of D‐dimers...

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Detalles Bibliográficos
Autores principales: Levi, Marcel, Hunt, Beverley J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Illustrated Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354416/
https://www.ncbi.nlm.nih.gov/pubmed/32685883
http://dx.doi.org/10.1002/rth2.12400
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author Levi, Marcel
Hunt, Beverley J.
author_facet Levi, Marcel
Hunt, Beverley J.
author_sort Levi, Marcel
collection PubMed
description This illustrated review discusses the haemostatic changes seen in patients with severe coronavirus disease 2019 (COVID‐19) infection and their possible causes. We discuss the crosstalk between inflammation and coagulation resulting in high levels of acute‐phase proteins, very high levels of D‐dimers, and absence of disseminated intravascular coagulation seen in patients with severe COVID‐19. There appear to be high rates of venous thromboembolism and also, what has been poorly described before in acute lung injury, a high rate of pulmonary immunothrombosis (thrombosis secondary to inflammation).
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spelling pubmed-73544162020-07-17 Thrombosis and coagulopathy in COVID‐19: An illustrated review Levi, Marcel Hunt, Beverley J. Res Pract Thromb Haemost Illustrated Review This illustrated review discusses the haemostatic changes seen in patients with severe coronavirus disease 2019 (COVID‐19) infection and their possible causes. We discuss the crosstalk between inflammation and coagulation resulting in high levels of acute‐phase proteins, very high levels of D‐dimers, and absence of disseminated intravascular coagulation seen in patients with severe COVID‐19. There appear to be high rates of venous thromboembolism and also, what has been poorly described before in acute lung injury, a high rate of pulmonary immunothrombosis (thrombosis secondary to inflammation). John Wiley and Sons Inc. 2020-07-11 /pmc/articles/PMC7354416/ /pubmed/32685883 http://dx.doi.org/10.1002/rth2.12400 Text en © 2020 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Illustrated Review
Levi, Marcel
Hunt, Beverley J.
Thrombosis and coagulopathy in COVID‐19: An illustrated review
title Thrombosis and coagulopathy in COVID‐19: An illustrated review
title_full Thrombosis and coagulopathy in COVID‐19: An illustrated review
title_fullStr Thrombosis and coagulopathy in COVID‐19: An illustrated review
title_full_unstemmed Thrombosis and coagulopathy in COVID‐19: An illustrated review
title_short Thrombosis and coagulopathy in COVID‐19: An illustrated review
title_sort thrombosis and coagulopathy in covid‐19: an illustrated review
topic Illustrated Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354416/
https://www.ncbi.nlm.nih.gov/pubmed/32685883
http://dx.doi.org/10.1002/rth2.12400
work_keys_str_mv AT levimarcel thrombosisandcoagulopathyincovid19anillustratedreview
AT huntbeverleyj thrombosisandcoagulopathyincovid19anillustratedreview

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