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Prevalence and Genetic Diversity of Atypical Porcine Pestivirus (APPV) Detected in South Korean Wild Boars

Atypical porcine pestivirus (APPV), currently classified as pestivirus K, causes congenital tremor (CT) type A-II in piglets. Eighteen APPV strains were identified from 2297 South Korean wild boars captured in 2019. Phylogenetic analysis of the structural protein E2 and nonstructural proteins NS3 an...

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Autores principales: Choe, SeEun, Park, Gyu-Nam, Cha, Ra Mi, Hyun, Bang-Hun, Park, Bong-Kyun, An, Dong-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354535/
https://www.ncbi.nlm.nih.gov/pubmed/32599836
http://dx.doi.org/10.3390/v12060680
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author Choe, SeEun
Park, Gyu-Nam
Cha, Ra Mi
Hyun, Bang-Hun
Park, Bong-Kyun
An, Dong-Jun
author_facet Choe, SeEun
Park, Gyu-Nam
Cha, Ra Mi
Hyun, Bang-Hun
Park, Bong-Kyun
An, Dong-Jun
author_sort Choe, SeEun
collection PubMed
description Atypical porcine pestivirus (APPV), currently classified as pestivirus K, causes congenital tremor (CT) type A-II in piglets. Eighteen APPV strains were identified from 2297 South Korean wild boars captured in 2019. Phylogenetic analysis of the structural protein E2 and nonstructural proteins NS3 and Npro classified the APPV viruses, including reference strains, into Clades I, II and III. Clade I was divided into four subclades; however, the strains belonging to the four subclades differed slightly, depending on the tree analysis, the NS3, E2, and Npro genes. The maximum-likelihood method was assigned to South Korean wild boar APPV strains to various subclades within the three trees: subclades I.1 and I.2 in the E2 tree, subclade I.1 in the Npro tree, and subclades I.1 and I.4 in the NS3 ML tree. In conclusion, APPV among South Korean wild boars belonging to Clade I may be circulating at a higher level than among the South Korean domestic pig populations.
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spelling pubmed-73545352020-08-05 Prevalence and Genetic Diversity of Atypical Porcine Pestivirus (APPV) Detected in South Korean Wild Boars Choe, SeEun Park, Gyu-Nam Cha, Ra Mi Hyun, Bang-Hun Park, Bong-Kyun An, Dong-Jun Viruses Article Atypical porcine pestivirus (APPV), currently classified as pestivirus K, causes congenital tremor (CT) type A-II in piglets. Eighteen APPV strains were identified from 2297 South Korean wild boars captured in 2019. Phylogenetic analysis of the structural protein E2 and nonstructural proteins NS3 and Npro classified the APPV viruses, including reference strains, into Clades I, II and III. Clade I was divided into four subclades; however, the strains belonging to the four subclades differed slightly, depending on the tree analysis, the NS3, E2, and Npro genes. The maximum-likelihood method was assigned to South Korean wild boar APPV strains to various subclades within the three trees: subclades I.1 and I.2 in the E2 tree, subclade I.1 in the Npro tree, and subclades I.1 and I.4 in the NS3 ML tree. In conclusion, APPV among South Korean wild boars belonging to Clade I may be circulating at a higher level than among the South Korean domestic pig populations. MDPI 2020-06-24 /pmc/articles/PMC7354535/ /pubmed/32599836 http://dx.doi.org/10.3390/v12060680 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choe, SeEun
Park, Gyu-Nam
Cha, Ra Mi
Hyun, Bang-Hun
Park, Bong-Kyun
An, Dong-Jun
Prevalence and Genetic Diversity of Atypical Porcine Pestivirus (APPV) Detected in South Korean Wild Boars
title Prevalence and Genetic Diversity of Atypical Porcine Pestivirus (APPV) Detected in South Korean Wild Boars
title_full Prevalence and Genetic Diversity of Atypical Porcine Pestivirus (APPV) Detected in South Korean Wild Boars
title_fullStr Prevalence and Genetic Diversity of Atypical Porcine Pestivirus (APPV) Detected in South Korean Wild Boars
title_full_unstemmed Prevalence and Genetic Diversity of Atypical Porcine Pestivirus (APPV) Detected in South Korean Wild Boars
title_short Prevalence and Genetic Diversity of Atypical Porcine Pestivirus (APPV) Detected in South Korean Wild Boars
title_sort prevalence and genetic diversity of atypical porcine pestivirus (appv) detected in south korean wild boars
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354535/
https://www.ncbi.nlm.nih.gov/pubmed/32599836
http://dx.doi.org/10.3390/v12060680
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