Cargando…
Epidemiology and Clinical Symptoms Related to Seasonal Coronavirus Identified in Patients with Acute Respiratory Infections Consulting in Primary Care over Six Influenza Seasons (2014–2020) in France
There is currently debate about human coronavirus (HCoV) seasonality and pathogenicity, as epidemiological data are scarce. Here, we provide epidemiological and clinical features of HCoV patients with acute respiratory infection (ARI) examined in primary care general practice. We also describe HCoV...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354536/ https://www.ncbi.nlm.nih.gov/pubmed/32532138 http://dx.doi.org/10.3390/v12060630 |
_version_ | 1783558107329200128 |
---|---|
author | Masse, Shirley Capai, Lisandru Villechenaud, Natacha Blanchon, Thierry Charrel, Rémi Falchi, Alessandra |
author_facet | Masse, Shirley Capai, Lisandru Villechenaud, Natacha Blanchon, Thierry Charrel, Rémi Falchi, Alessandra |
author_sort | Masse, Shirley |
collection | PubMed |
description | There is currently debate about human coronavirus (HCoV) seasonality and pathogenicity, as epidemiological data are scarce. Here, we provide epidemiological and clinical features of HCoV patients with acute respiratory infection (ARI) examined in primary care general practice. We also describe HCoV seasonality over six influenza surveillance seasons (week 40 to 15 of each season) from the period 2014/2015 to 2019/2020 in Corsica (France). A sample of patients of all ages presenting for consultation for influenza-like illness (ILI) or ARI was included by physicians of the French Sentinelles Network during this period. Nasopharyngeal samples were tested for the presence of 21 respiratory pathogens by real-time RT-PCR. Among the 1389 ILI/ARI patients, 105 were positive for at least one HCoV (7.5%). On an annual basis, HCoVs circulated from week 48 (November) to weeks 14–15 (May) and peaked in week 6 (February). Overall, among the HCoV-positive patients detected in this study, HCoV-OC43 was the most commonly detected virus, followed by HCoV-NL63, HCoV-HKU1, and HCoV-229E. The HCoV detection rates varied significantly with age (p = 0.00005), with the age group 0–14 years accounting for 28.6% (n = 30) of HCoV-positive patients. Fever and malaise were less frequent in HCoV patients than in influenza patients, while sore throat, dyspnoea, rhinorrhoea, and conjunctivitis were more associated with HCoV positivity. In conclusion, this study demonstrates that HCoV subtypes appear in ARI/ILI patients seen in general practice, with characteristic outbreak patterns primarily in winter. This study also identified symptoms associated with HCoVs in patients with ARI/ILI. Further studies with representative samples should be conducted to provide additional insights into the epidemiology and clinical features of HCoVs. |
format | Online Article Text |
id | pubmed-7354536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73545362020-07-23 Epidemiology and Clinical Symptoms Related to Seasonal Coronavirus Identified in Patients with Acute Respiratory Infections Consulting in Primary Care over Six Influenza Seasons (2014–2020) in France Masse, Shirley Capai, Lisandru Villechenaud, Natacha Blanchon, Thierry Charrel, Rémi Falchi, Alessandra Viruses Article There is currently debate about human coronavirus (HCoV) seasonality and pathogenicity, as epidemiological data are scarce. Here, we provide epidemiological and clinical features of HCoV patients with acute respiratory infection (ARI) examined in primary care general practice. We also describe HCoV seasonality over six influenza surveillance seasons (week 40 to 15 of each season) from the period 2014/2015 to 2019/2020 in Corsica (France). A sample of patients of all ages presenting for consultation for influenza-like illness (ILI) or ARI was included by physicians of the French Sentinelles Network during this period. Nasopharyngeal samples were tested for the presence of 21 respiratory pathogens by real-time RT-PCR. Among the 1389 ILI/ARI patients, 105 were positive for at least one HCoV (7.5%). On an annual basis, HCoVs circulated from week 48 (November) to weeks 14–15 (May) and peaked in week 6 (February). Overall, among the HCoV-positive patients detected in this study, HCoV-OC43 was the most commonly detected virus, followed by HCoV-NL63, HCoV-HKU1, and HCoV-229E. The HCoV detection rates varied significantly with age (p = 0.00005), with the age group 0–14 years accounting for 28.6% (n = 30) of HCoV-positive patients. Fever and malaise were less frequent in HCoV patients than in influenza patients, while sore throat, dyspnoea, rhinorrhoea, and conjunctivitis were more associated with HCoV positivity. In conclusion, this study demonstrates that HCoV subtypes appear in ARI/ILI patients seen in general practice, with characteristic outbreak patterns primarily in winter. This study also identified symptoms associated with HCoVs in patients with ARI/ILI. Further studies with representative samples should be conducted to provide additional insights into the epidemiology and clinical features of HCoVs. MDPI 2020-06-10 /pmc/articles/PMC7354536/ /pubmed/32532138 http://dx.doi.org/10.3390/v12060630 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Masse, Shirley Capai, Lisandru Villechenaud, Natacha Blanchon, Thierry Charrel, Rémi Falchi, Alessandra Epidemiology and Clinical Symptoms Related to Seasonal Coronavirus Identified in Patients with Acute Respiratory Infections Consulting in Primary Care over Six Influenza Seasons (2014–2020) in France |
title | Epidemiology and Clinical Symptoms Related to Seasonal Coronavirus Identified in Patients with Acute Respiratory Infections Consulting in Primary Care over Six Influenza Seasons (2014–2020) in France |
title_full | Epidemiology and Clinical Symptoms Related to Seasonal Coronavirus Identified in Patients with Acute Respiratory Infections Consulting in Primary Care over Six Influenza Seasons (2014–2020) in France |
title_fullStr | Epidemiology and Clinical Symptoms Related to Seasonal Coronavirus Identified in Patients with Acute Respiratory Infections Consulting in Primary Care over Six Influenza Seasons (2014–2020) in France |
title_full_unstemmed | Epidemiology and Clinical Symptoms Related to Seasonal Coronavirus Identified in Patients with Acute Respiratory Infections Consulting in Primary Care over Six Influenza Seasons (2014–2020) in France |
title_short | Epidemiology and Clinical Symptoms Related to Seasonal Coronavirus Identified in Patients with Acute Respiratory Infections Consulting in Primary Care over Six Influenza Seasons (2014–2020) in France |
title_sort | epidemiology and clinical symptoms related to seasonal coronavirus identified in patients with acute respiratory infections consulting in primary care over six influenza seasons (2014–2020) in france |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354536/ https://www.ncbi.nlm.nih.gov/pubmed/32532138 http://dx.doi.org/10.3390/v12060630 |
work_keys_str_mv | AT masseshirley epidemiologyandclinicalsymptomsrelatedtoseasonalcoronavirusidentifiedinpatientswithacuterespiratoryinfectionsconsultinginprimarycareoversixinfluenzaseasons20142020infrance AT capailisandru epidemiologyandclinicalsymptomsrelatedtoseasonalcoronavirusidentifiedinpatientswithacuterespiratoryinfectionsconsultinginprimarycareoversixinfluenzaseasons20142020infrance AT villechenaudnatacha epidemiologyandclinicalsymptomsrelatedtoseasonalcoronavirusidentifiedinpatientswithacuterespiratoryinfectionsconsultinginprimarycareoversixinfluenzaseasons20142020infrance AT blanchonthierry epidemiologyandclinicalsymptomsrelatedtoseasonalcoronavirusidentifiedinpatientswithacuterespiratoryinfectionsconsultinginprimarycareoversixinfluenzaseasons20142020infrance AT charrelremi epidemiologyandclinicalsymptomsrelatedtoseasonalcoronavirusidentifiedinpatientswithacuterespiratoryinfectionsconsultinginprimarycareoversixinfluenzaseasons20142020infrance AT falchialessandra epidemiologyandclinicalsymptomsrelatedtoseasonalcoronavirusidentifiedinpatientswithacuterespiratoryinfectionsconsultinginprimarycareoversixinfluenzaseasons20142020infrance |