The Interplay between Adeno-Associated Virus and Its Helper Viruses

The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on helper factors to replicate. Those helper factors can be provided by coinfecting helper viruses such as adenoviruses, herpesviruses, or papillomaviruses. We review the basic biology of AAV and its most-studied he...

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Autores principales: Meier, Anita F., Fraefel, Cornel, Seyffert, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354565/
https://www.ncbi.nlm.nih.gov/pubmed/32575422
http://dx.doi.org/10.3390/v12060662
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author Meier, Anita F.
Fraefel, Cornel
Seyffert, Michael
author_facet Meier, Anita F.
Fraefel, Cornel
Seyffert, Michael
author_sort Meier, Anita F.
collection PubMed
description The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on helper factors to replicate. Those helper factors can be provided by coinfecting helper viruses such as adenoviruses, herpesviruses, or papillomaviruses. We review the basic biology of AAV and its most-studied helper viruses, adenovirus type 5 (AdV5) and herpes simplex virus type 1 (HSV-1). We further outline the direct and indirect interactions of AAV with those and additional helper viruses.
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spelling pubmed-73545652020-07-23 The Interplay between Adeno-Associated Virus and Its Helper Viruses Meier, Anita F. Fraefel, Cornel Seyffert, Michael Viruses Review The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on helper factors to replicate. Those helper factors can be provided by coinfecting helper viruses such as adenoviruses, herpesviruses, or papillomaviruses. We review the basic biology of AAV and its most-studied helper viruses, adenovirus type 5 (AdV5) and herpes simplex virus type 1 (HSV-1). We further outline the direct and indirect interactions of AAV with those and additional helper viruses. MDPI 2020-06-19 /pmc/articles/PMC7354565/ /pubmed/32575422 http://dx.doi.org/10.3390/v12060662 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Meier, Anita F.
Fraefel, Cornel
Seyffert, Michael
The Interplay between Adeno-Associated Virus and Its Helper Viruses
title The Interplay between Adeno-Associated Virus and Its Helper Viruses
title_full The Interplay between Adeno-Associated Virus and Its Helper Viruses
title_fullStr The Interplay between Adeno-Associated Virus and Its Helper Viruses
title_full_unstemmed The Interplay between Adeno-Associated Virus and Its Helper Viruses
title_short The Interplay between Adeno-Associated Virus and Its Helper Viruses
title_sort interplay between adeno-associated virus and its helper viruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354565/
https://www.ncbi.nlm.nih.gov/pubmed/32575422
http://dx.doi.org/10.3390/v12060662
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