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Recent Advances on Macrocyclic Trichothecenes, Their Bioactivities and Biosynthetic Pathway

Macrocyclic trichothecenes are an important group of trichothecenes bearing a large ring. Despite the fact that many of trichothecenes are of concern in agriculture, food contamination, health care and building protection, the macrocyclic ones are becoming the research hotspot because of their diver...

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Autores principales: Zhu, Muzi, Cen, Youfei, Ye, Wei, Li, Saini, Zhang, Weimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354583/
https://www.ncbi.nlm.nih.gov/pubmed/32585939
http://dx.doi.org/10.3390/toxins12060417
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author Zhu, Muzi
Cen, Youfei
Ye, Wei
Li, Saini
Zhang, Weimin
author_facet Zhu, Muzi
Cen, Youfei
Ye, Wei
Li, Saini
Zhang, Weimin
author_sort Zhu, Muzi
collection PubMed
description Macrocyclic trichothecenes are an important group of trichothecenes bearing a large ring. Despite the fact that many of trichothecenes are of concern in agriculture, food contamination, health care and building protection, the macrocyclic ones are becoming the research hotspot because of their diversity in structure and biologic activity. Several researchers have declared that macrocyclic trichothecenes have great potential to be developed as antitumor agents, due to the plenty of their compounds and bioactivities. In this review we summarize the newly discovered macrocyclic trichothecenes and their bioactivities over the last decade, as well as identifications of genes tri17 and tri18 involved in the trichothecene biosynthesis and putative biosynthetic pathway. According to the search results in database and phylogenetic trees generated in the review, the species of the genera Podostroma and Monosporascus would probably be great sources for producing macrocyclic trichothecenes. Moreover, we propose that the macrocyclic trichothecene roridin E could be formed via acylation or esterification of the long side chain linked with C-4 to the hydroxyl group at C-15, and vice versa. More assays and evidences are needed to support this hypothesis, which would promote the verification of the proposed pathway.
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spelling pubmed-73545832020-07-23 Recent Advances on Macrocyclic Trichothecenes, Their Bioactivities and Biosynthetic Pathway Zhu, Muzi Cen, Youfei Ye, Wei Li, Saini Zhang, Weimin Toxins (Basel) Review Macrocyclic trichothecenes are an important group of trichothecenes bearing a large ring. Despite the fact that many of trichothecenes are of concern in agriculture, food contamination, health care and building protection, the macrocyclic ones are becoming the research hotspot because of their diversity in structure and biologic activity. Several researchers have declared that macrocyclic trichothecenes have great potential to be developed as antitumor agents, due to the plenty of their compounds and bioactivities. In this review we summarize the newly discovered macrocyclic trichothecenes and their bioactivities over the last decade, as well as identifications of genes tri17 and tri18 involved in the trichothecene biosynthesis and putative biosynthetic pathway. According to the search results in database and phylogenetic trees generated in the review, the species of the genera Podostroma and Monosporascus would probably be great sources for producing macrocyclic trichothecenes. Moreover, we propose that the macrocyclic trichothecene roridin E could be formed via acylation or esterification of the long side chain linked with C-4 to the hydroxyl group at C-15, and vice versa. More assays and evidences are needed to support this hypothesis, which would promote the verification of the proposed pathway. MDPI 2020-06-23 /pmc/articles/PMC7354583/ /pubmed/32585939 http://dx.doi.org/10.3390/toxins12060417 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhu, Muzi
Cen, Youfei
Ye, Wei
Li, Saini
Zhang, Weimin
Recent Advances on Macrocyclic Trichothecenes, Their Bioactivities and Biosynthetic Pathway
title Recent Advances on Macrocyclic Trichothecenes, Their Bioactivities and Biosynthetic Pathway
title_full Recent Advances on Macrocyclic Trichothecenes, Their Bioactivities and Biosynthetic Pathway
title_fullStr Recent Advances on Macrocyclic Trichothecenes, Their Bioactivities and Biosynthetic Pathway
title_full_unstemmed Recent Advances on Macrocyclic Trichothecenes, Their Bioactivities and Biosynthetic Pathway
title_short Recent Advances on Macrocyclic Trichothecenes, Their Bioactivities and Biosynthetic Pathway
title_sort recent advances on macrocyclic trichothecenes, their bioactivities and biosynthetic pathway
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354583/
https://www.ncbi.nlm.nih.gov/pubmed/32585939
http://dx.doi.org/10.3390/toxins12060417
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