Cargando…
The Emerging Role of MicroRNAs in Breast Cancer
Breast cancer (BC) is the most common malignancy in women. Due to BC heterogeneity, complexity, and metastasis, many BC patients do not successfully respond to therapies. The effective management of BC depends on early diagnosis and monitoring of drug response. Therefore, identifying new biomarkers...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354667/ https://www.ncbi.nlm.nih.gov/pubmed/32714393 http://dx.doi.org/10.1155/2020/9160905 |
_version_ | 1783558138871414784 |
---|---|
author | Yang, Zhiguang Liu, Zhaoyu |
author_facet | Yang, Zhiguang Liu, Zhaoyu |
author_sort | Yang, Zhiguang |
collection | PubMed |
description | Breast cancer (BC) is the most common malignancy in women. Due to BC heterogeneity, complexity, and metastasis, many BC patients do not successfully respond to therapies. The effective management of BC depends on early diagnosis and monitoring of drug response. Therefore, identifying new biomarkers for the diagnosis, prognosis, and development of new drugs is urgently required. Dysregulation of microRNAs (miRNAs) participates in the tumorigenesis and progression of cancers, especially breast cancer (BC). Several studies demonstrated that miRNAs could perform their function as oncogenes or tumor suppressors. This review describes recent progress on the role of microRNAs in the diagnosis, prognosis, hallmark, and treatment of BC. According to a recent literature survey, miRNAs play a pivotal role in the regulation of hallmarks of cancer, such as proliferation, apoptosis, invasion, metastasis, and tumor stemness. Many miRNAs are potential biomarkers for BC for diagnosis, and some are indicators of prognosis. Moreover, circulating miRNA profiles, as minimally invasive, diagnostic, and prognostic markers, are broadly used in BC therapy, and some miRNAs are good predictors of therapeutic outcomes. Other miRNAs are involved in overcoming chemoresistance and in increasing BC drug sensitivity. |
format | Online Article Text |
id | pubmed-7354667 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-73546672020-07-23 The Emerging Role of MicroRNAs in Breast Cancer Yang, Zhiguang Liu, Zhaoyu J Oncol Review Article Breast cancer (BC) is the most common malignancy in women. Due to BC heterogeneity, complexity, and metastasis, many BC patients do not successfully respond to therapies. The effective management of BC depends on early diagnosis and monitoring of drug response. Therefore, identifying new biomarkers for the diagnosis, prognosis, and development of new drugs is urgently required. Dysregulation of microRNAs (miRNAs) participates in the tumorigenesis and progression of cancers, especially breast cancer (BC). Several studies demonstrated that miRNAs could perform their function as oncogenes or tumor suppressors. This review describes recent progress on the role of microRNAs in the diagnosis, prognosis, hallmark, and treatment of BC. According to a recent literature survey, miRNAs play a pivotal role in the regulation of hallmarks of cancer, such as proliferation, apoptosis, invasion, metastasis, and tumor stemness. Many miRNAs are potential biomarkers for BC for diagnosis, and some are indicators of prognosis. Moreover, circulating miRNA profiles, as minimally invasive, diagnostic, and prognostic markers, are broadly used in BC therapy, and some miRNAs are good predictors of therapeutic outcomes. Other miRNAs are involved in overcoming chemoresistance and in increasing BC drug sensitivity. Hindawi 2020-07-03 /pmc/articles/PMC7354667/ /pubmed/32714393 http://dx.doi.org/10.1155/2020/9160905 Text en Copyright © 2020 Zhiguang Yang and Zhaoyu Liu. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Yang, Zhiguang Liu, Zhaoyu The Emerging Role of MicroRNAs in Breast Cancer |
title | The Emerging Role of MicroRNAs in Breast Cancer |
title_full | The Emerging Role of MicroRNAs in Breast Cancer |
title_fullStr | The Emerging Role of MicroRNAs in Breast Cancer |
title_full_unstemmed | The Emerging Role of MicroRNAs in Breast Cancer |
title_short | The Emerging Role of MicroRNAs in Breast Cancer |
title_sort | emerging role of micrornas in breast cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354667/ https://www.ncbi.nlm.nih.gov/pubmed/32714393 http://dx.doi.org/10.1155/2020/9160905 |
work_keys_str_mv | AT yangzhiguang theemergingroleofmicrornasinbreastcancer AT liuzhaoyu theemergingroleofmicrornasinbreastcancer AT yangzhiguang emergingroleofmicrornasinbreastcancer AT liuzhaoyu emergingroleofmicrornasinbreastcancer |