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Painless thyroiditis in a dupilumab-treated patient

SUMMARY: Dupilumab an inhibitor of the interleukin (IL)-4R-alpha subunit is used for the treatment of allergic diseases. The patient was a 49-year-old man who received dupilumab for the treatment of severe atopic dermatitis. He presented hyperthyroidism with elevated thyroglobulin and anti-thyroid a...

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Autores principales: Narantsatsral, Daramjav, Junko, Takagi, Hideyuki, Iwayama, Daisuke, Inukai, Hiroyuki, Takama, Yuka, Nomura, Syo, Hirase, Hiroyuki, Morita, Kazuo, Otake, Tetsuya, Ogawa, Akiyoshi, Takami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354710/
https://www.ncbi.nlm.nih.gov/pubmed/32554823
http://dx.doi.org/10.1530/EDM-20-0030
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author Narantsatsral, Daramjav
Junko, Takagi
Hideyuki, Iwayama
Daisuke, Inukai
Hiroyuki, Takama
Yuka, Nomura
Syo, Hirase
Hiroyuki, Morita
Kazuo, Otake
Tetsuya, Ogawa
Akiyoshi, Takami
author_facet Narantsatsral, Daramjav
Junko, Takagi
Hideyuki, Iwayama
Daisuke, Inukai
Hiroyuki, Takama
Yuka, Nomura
Syo, Hirase
Hiroyuki, Morita
Kazuo, Otake
Tetsuya, Ogawa
Akiyoshi, Takami
author_sort Narantsatsral, Daramjav
collection PubMed
description SUMMARY: Dupilumab an inhibitor of the interleukin (IL)-4R-alpha subunit is used for the treatment of allergic diseases. The patient was a 49-year-old man who received dupilumab for the treatment of severe atopic dermatitis. He presented hyperthyroidism with elevated thyroglobulin and anti-thyroid antibody negativity at 4 months after the initiation of therapy. On scintigraphy, the thyroid radioiodine uptake was low. Ultrasonography showed a diffuse hypoechoic area in the thyroid gland. A pathological study revealed lymphocytic infiltration. The administration of dupilumab was continued because of his atopic dermatitis that showed an excellent response. The patient`s hyperthyroidism changed to hypothyroidism 3 weeks later. Six months later his thyroid function normalized without any treatment. We herein describe the case of a patient with atopic dermatitis who developed painless thyroiditis under treatment with dupilumab. To the best of our knowledge, this is the first report of this event in the literature. LEARNING POINTS: Dupilumab, a fully human monoclonal antibody that blocks interleukin-4 and interleukin-13, has been shown to be effective in the treatment atopic dermatitis and asthma with eosinophilia. Painless thyroiditis is characterized by transient hyperthyroidism and hypothyroidism and recovery without anti-thyroid treatment. This is the first report of painless thyroiditis as an adverse effect of dupilumab, although conjunctivitis and nasopharyngitis are the main adverse effects of dupilumab.
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spelling pubmed-73547102020-07-15 Painless thyroiditis in a dupilumab-treated patient Narantsatsral, Daramjav Junko, Takagi Hideyuki, Iwayama Daisuke, Inukai Hiroyuki, Takama Yuka, Nomura Syo, Hirase Hiroyuki, Morita Kazuo, Otake Tetsuya, Ogawa Akiyoshi, Takami Endocrinol Diabetes Metab Case Rep Unusual Effects of Medical Treatment SUMMARY: Dupilumab an inhibitor of the interleukin (IL)-4R-alpha subunit is used for the treatment of allergic diseases. The patient was a 49-year-old man who received dupilumab for the treatment of severe atopic dermatitis. He presented hyperthyroidism with elevated thyroglobulin and anti-thyroid antibody negativity at 4 months after the initiation of therapy. On scintigraphy, the thyroid radioiodine uptake was low. Ultrasonography showed a diffuse hypoechoic area in the thyroid gland. A pathological study revealed lymphocytic infiltration. The administration of dupilumab was continued because of his atopic dermatitis that showed an excellent response. The patient`s hyperthyroidism changed to hypothyroidism 3 weeks later. Six months later his thyroid function normalized without any treatment. We herein describe the case of a patient with atopic dermatitis who developed painless thyroiditis under treatment with dupilumab. To the best of our knowledge, this is the first report of this event in the literature. LEARNING POINTS: Dupilumab, a fully human monoclonal antibody that blocks interleukin-4 and interleukin-13, has been shown to be effective in the treatment atopic dermatitis and asthma with eosinophilia. Painless thyroiditis is characterized by transient hyperthyroidism and hypothyroidism and recovery without anti-thyroid treatment. This is the first report of painless thyroiditis as an adverse effect of dupilumab, although conjunctivitis and nasopharyngitis are the main adverse effects of dupilumab. Bioscientifica Ltd 2020-06-16 /pmc/articles/PMC7354710/ /pubmed/32554823 http://dx.doi.org/10.1530/EDM-20-0030 Text en © 2020 The authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. (http://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Unusual Effects of Medical Treatment
Narantsatsral, Daramjav
Junko, Takagi
Hideyuki, Iwayama
Daisuke, Inukai
Hiroyuki, Takama
Yuka, Nomura
Syo, Hirase
Hiroyuki, Morita
Kazuo, Otake
Tetsuya, Ogawa
Akiyoshi, Takami
Painless thyroiditis in a dupilumab-treated patient
title Painless thyroiditis in a dupilumab-treated patient
title_full Painless thyroiditis in a dupilumab-treated patient
title_fullStr Painless thyroiditis in a dupilumab-treated patient
title_full_unstemmed Painless thyroiditis in a dupilumab-treated patient
title_short Painless thyroiditis in a dupilumab-treated patient
title_sort painless thyroiditis in a dupilumab-treated patient
topic Unusual Effects of Medical Treatment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354710/
https://www.ncbi.nlm.nih.gov/pubmed/32554823
http://dx.doi.org/10.1530/EDM-20-0030
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