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Clinical Spectrum of Myelin Oligodendrocyte Glycoprotein-Immunoglobulin G-Associated Disease in Korean Children

BACKGROUND AND PURPOSE: The myelin oligodendrocyte glycoprotein (MOG) antibody is detected at a high rate in childhood acquired demyelinating syndrome (ADS). This study aimed to determine the diagnostic value of the MOG antibody in ADS and the spectrum of MOG-antibody-positive demyelinating diseases...

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Autores principales: Yoo, Il Han, Kim, WooJoong, Shim, Youngkyu, Choi, Sun Ah, Kim, Soo Yeon, Kim, Hunmin, Lim, Byung Chan, Hwang, Hee, Choi, Jieun, Kim, Ki Joong, Kim, Yeseul, Hyun, Jae-Won, Kim, Su-Hyun, Choi, Kyungho, Kim, Ho Jin, Chae, Jong-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neurological Association 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354962/
https://www.ncbi.nlm.nih.gov/pubmed/32657068
http://dx.doi.org/10.3988/jcn.2020.16.3.461
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author Yoo, Il Han
Kim, WooJoong
Shim, Youngkyu
Choi, Sun Ah
Kim, Soo Yeon
Kim, Hunmin
Lim, Byung Chan
Hwang, Hee
Choi, Jieun
Kim, Ki Joong
Kim, Yeseul
Hyun, Jae-Won
Kim, Su-Hyun
Choi, Kyungho
Kim, Ho Jin
Chae, Jong-Hee
author_facet Yoo, Il Han
Kim, WooJoong
Shim, Youngkyu
Choi, Sun Ah
Kim, Soo Yeon
Kim, Hunmin
Lim, Byung Chan
Hwang, Hee
Choi, Jieun
Kim, Ki Joong
Kim, Yeseul
Hyun, Jae-Won
Kim, Su-Hyun
Choi, Kyungho
Kim, Ho Jin
Chae, Jong-Hee
author_sort Yoo, Il Han
collection PubMed
description BACKGROUND AND PURPOSE: The myelin oligodendrocyte glycoprotein (MOG) antibody is detected at a high rate in childhood acquired demyelinating syndrome (ADS). This study aimed to determine the diagnostic value of the MOG antibody in ADS and the spectrum of MOG-antibody-positive demyelinating diseases in children. METHODS: This study included 128 patients diagnosed with ADS (n=94) or unexplained encephalitis (n=34). The MOG antibody in serum was tested using an in-house live-cell-based immunofluorescence assay. RESULTS: The MOG antibody was detected in 48 patients (46 ADS patients and 2 encephalitis patients, comprising 23 males and 25 females). Acute disseminated encephalomyelitis (ADEM) (35.4%) was the most-common diagnosis, followed by the unclassified form (17.4%), isolated optic neuritis (ON) (15.2%), neuromyelitis optica spectrum disorder (13.0%), multiple sclerosis (MS) (10.8%), other clinically isolated syndromes [monophasic event except ADEM, isolated ON, or transverse myelitis (TM)] (8.7%), and unexplained encephalitis (4.3%). At the initial presentation, 35 out of the 46 patients with ADS had brain lesions detected in magnetic resonance imaging, and 54% of these 35 patients had encephalopathy. Nine of the 11 patients without brain lesions exhibited only ON. Thirty-nine percent of the patients experienced a multiphasic event during the mean follow-up period of 34.9 months (range 1.4–169.0 months). Encephalopathy at the initial presentation was frequently confirmed in the monophasic group (p=0.011). CONCLUSIONS: MOG antibodies were identified in all pediatric ADS phenotypes except for monophasic TM. Therefore, the MOG antibody test is recommended for all pediatric patients with ADS, especially before a diagnosis of MS and for patients without a clear diagnosis.
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spelling pubmed-73549622020-07-22 Clinical Spectrum of Myelin Oligodendrocyte Glycoprotein-Immunoglobulin G-Associated Disease in Korean Children Yoo, Il Han Kim, WooJoong Shim, Youngkyu Choi, Sun Ah Kim, Soo Yeon Kim, Hunmin Lim, Byung Chan Hwang, Hee Choi, Jieun Kim, Ki Joong Kim, Yeseul Hyun, Jae-Won Kim, Su-Hyun Choi, Kyungho Kim, Ho Jin Chae, Jong-Hee J Clin Neurol Original Article BACKGROUND AND PURPOSE: The myelin oligodendrocyte glycoprotein (MOG) antibody is detected at a high rate in childhood acquired demyelinating syndrome (ADS). This study aimed to determine the diagnostic value of the MOG antibody in ADS and the spectrum of MOG-antibody-positive demyelinating diseases in children. METHODS: This study included 128 patients diagnosed with ADS (n=94) or unexplained encephalitis (n=34). The MOG antibody in serum was tested using an in-house live-cell-based immunofluorescence assay. RESULTS: The MOG antibody was detected in 48 patients (46 ADS patients and 2 encephalitis patients, comprising 23 males and 25 females). Acute disseminated encephalomyelitis (ADEM) (35.4%) was the most-common diagnosis, followed by the unclassified form (17.4%), isolated optic neuritis (ON) (15.2%), neuromyelitis optica spectrum disorder (13.0%), multiple sclerosis (MS) (10.8%), other clinically isolated syndromes [monophasic event except ADEM, isolated ON, or transverse myelitis (TM)] (8.7%), and unexplained encephalitis (4.3%). At the initial presentation, 35 out of the 46 patients with ADS had brain lesions detected in magnetic resonance imaging, and 54% of these 35 patients had encephalopathy. Nine of the 11 patients without brain lesions exhibited only ON. Thirty-nine percent of the patients experienced a multiphasic event during the mean follow-up period of 34.9 months (range 1.4–169.0 months). Encephalopathy at the initial presentation was frequently confirmed in the monophasic group (p=0.011). CONCLUSIONS: MOG antibodies were identified in all pediatric ADS phenotypes except for monophasic TM. Therefore, the MOG antibody test is recommended for all pediatric patients with ADS, especially before a diagnosis of MS and for patients without a clear diagnosis. Korean Neurological Association 2020-07 2020-07-01 /pmc/articles/PMC7354962/ /pubmed/32657068 http://dx.doi.org/10.3988/jcn.2020.16.3.461 Text en Copyright © 2020 Korean Neurological Association http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yoo, Il Han
Kim, WooJoong
Shim, Youngkyu
Choi, Sun Ah
Kim, Soo Yeon
Kim, Hunmin
Lim, Byung Chan
Hwang, Hee
Choi, Jieun
Kim, Ki Joong
Kim, Yeseul
Hyun, Jae-Won
Kim, Su-Hyun
Choi, Kyungho
Kim, Ho Jin
Chae, Jong-Hee
Clinical Spectrum of Myelin Oligodendrocyte Glycoprotein-Immunoglobulin G-Associated Disease in Korean Children
title Clinical Spectrum of Myelin Oligodendrocyte Glycoprotein-Immunoglobulin G-Associated Disease in Korean Children
title_full Clinical Spectrum of Myelin Oligodendrocyte Glycoprotein-Immunoglobulin G-Associated Disease in Korean Children
title_fullStr Clinical Spectrum of Myelin Oligodendrocyte Glycoprotein-Immunoglobulin G-Associated Disease in Korean Children
title_full_unstemmed Clinical Spectrum of Myelin Oligodendrocyte Glycoprotein-Immunoglobulin G-Associated Disease in Korean Children
title_short Clinical Spectrum of Myelin Oligodendrocyte Glycoprotein-Immunoglobulin G-Associated Disease in Korean Children
title_sort clinical spectrum of myelin oligodendrocyte glycoprotein-immunoglobulin g-associated disease in korean children
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354962/
https://www.ncbi.nlm.nih.gov/pubmed/32657068
http://dx.doi.org/10.3988/jcn.2020.16.3.461
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