Nucleosides Rescue Replication-Mediated Genome Instability of Human Pluripotent Stem Cells

Human pluripotent stem cells (PSCs) are subject to the appearance of recurrent genetic variants on prolonged culture. We have now found that, compared with isogenic differentiated cells, PSCs exhibit evidence of considerably more DNA damage during the S phase of the cell cycle, apparently as a conse...

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Detalles Bibliográficos
Autores principales: Halliwell, Jason A., Frith, Thomas J.R., Laing, Owen, Price, Christopher J., Bower, Oliver J., Stavish, Dylan, Gokhale, Paul J., Hewitt, Zoe, El-Khamisy, Sherif F., Barbaric, Ivana, Andrews, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355123/
https://www.ncbi.nlm.nih.gov/pubmed/32413278
http://dx.doi.org/10.1016/j.stemcr.2020.04.004

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