Integrating stem cell-based experiments in clinical research

With the seminal discovery of somatic cell reprogramming with defined genetic factors, it is now a routine laboratory procedure to reprogram somatic cells to generate patient-specific induced pluripotent stem cells (iPSCs) [1] Patient-specific iPSCs can be differentiated to generate mature neurons a...

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Detalles Bibliográficos
Autores principales: Karmacharya, Rakesh, Kieling, Christian, Mondelli, Valeria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355166/
https://www.ncbi.nlm.nih.gov/pubmed/32536357
http://dx.doi.org/10.1192/j.eurpsy.2020.64
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author Karmacharya, Rakesh
Kieling, Christian
Mondelli, Valeria
author_facet Karmacharya, Rakesh
Kieling, Christian
Mondelli, Valeria
author_sort Karmacharya, Rakesh
collection PubMed
description With the seminal discovery of somatic cell reprogramming with defined genetic factors, it is now a routine laboratory procedure to reprogram somatic cells to generate patient-specific induced pluripotent stem cells (iPSCs) [1] Patient-specific iPSCs can be differentiated to generate mature neurons as well as three-dimensional brain organoids that show appropriate functional activity in electrophysiological studies [2,3]. However, there is a significant gap in the thoughtful incorporation of patient-derived neuronal cells in clinical studies addressing disease risk.
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spelling pubmed-73551662020-07-17 Integrating stem cell-based experiments in clinical research Karmacharya, Rakesh Kieling, Christian Mondelli, Valeria Eur Psychiatry Viewpoint With the seminal discovery of somatic cell reprogramming with defined genetic factors, it is now a routine laboratory procedure to reprogram somatic cells to generate patient-specific induced pluripotent stem cells (iPSCs) [1] Patient-specific iPSCs can be differentiated to generate mature neurons as well as three-dimensional brain organoids that show appropriate functional activity in electrophysiological studies [2,3]. However, there is a significant gap in the thoughtful incorporation of patient-derived neuronal cells in clinical studies addressing disease risk. Cambridge University Press 2020-06-15 /pmc/articles/PMC7355166/ /pubmed/32536357 http://dx.doi.org/10.1192/j.eurpsy.2020.64 Text en © The Author(s) 2020 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Viewpoint
Karmacharya, Rakesh
Kieling, Christian
Mondelli, Valeria
Integrating stem cell-based experiments in clinical research
title Integrating stem cell-based experiments in clinical research
title_full Integrating stem cell-based experiments in clinical research
title_fullStr Integrating stem cell-based experiments in clinical research
title_full_unstemmed Integrating stem cell-based experiments in clinical research
title_short Integrating stem cell-based experiments in clinical research
title_sort integrating stem cell-based experiments in clinical research
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355166/
https://www.ncbi.nlm.nih.gov/pubmed/32536357
http://dx.doi.org/10.1192/j.eurpsy.2020.64
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