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MAGGIE: leveraging genetic variation to identify DNA sequence motifs mediating transcription factor binding and function
MOTIVATION: Genetic variation in regulatory elements can alter transcription factor (TF) binding by mutating a TF binding motif, which in turn may affect the activity of the regulatory elements. However, it is unclear which motifs are prone to impact transcriptional regulation if mutated. Current mo...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355228/ https://www.ncbi.nlm.nih.gov/pubmed/32657363 http://dx.doi.org/10.1093/bioinformatics/btaa476 |