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The ortholog conjecture revisited: the value of orthologs and paralogs in function prediction

MOTIVATION: The computational prediction of gene function is a key step in making full use of newly sequenced genomes. Function is generally predicted by transferring annotations from homologous genes or proteins for which experimental evidence exists. The ‘ortholog conjecture’ proposes that ortholo...

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Detalles Bibliográficos
Autores principales:	Stamboulian, Moses, Guerrero, Rafael F, Hahn, Matthew W, Radivojac, Predrag
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Macromolecular Sequence, Structure, and Function
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355290/ https://www.ncbi.nlm.nih.gov/pubmed/32657391 http://dx.doi.org/10.1093/bioinformatics/btaa468

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