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Network-principled deep generative models for designing drug combinations as graph sets

MOTIVATION: Combination therapy has shown to improve therapeutic efficacy while reducing side effects. Importantly, it has become an indispensable strategy to overcome resistance in antibiotics, antimicrobials and anticancer drugs. Facing enormous chemical space and unclear design principles for sma...

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Detalles Bibliográficos
Autores principales:	Karimi, Mostafa, Hasanzadeh, Arman, Shen, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Studies of Phenotypes and Clinical Applications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355302/ https://www.ncbi.nlm.nih.gov/pubmed/32657357 http://dx.doi.org/10.1093/bioinformatics/btaa317

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