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Independent Predictive Ability of Procalcitonin of Acute Kidney Injury among Critically Ill Patients

It is unclear whether serum procalcitonin (PCT) levels rise in patients with acute kidney injury (AKI), and it is also unclear whether the elevation of PCT levels in this setting is independent of the existence of infection and impaired renal clearance. We conducted a retrospective study in a region...

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Autores principales: Huang, Ya-Ting, Lai, Min-Yu, Kan, Wei-Chih, Shiao, Chih-Chung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355446/
https://www.ncbi.nlm.nih.gov/pubmed/32575833
http://dx.doi.org/10.3390/jcm9061939
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author Huang, Ya-Ting
Lai, Min-Yu
Kan, Wei-Chih
Shiao, Chih-Chung
author_facet Huang, Ya-Ting
Lai, Min-Yu
Kan, Wei-Chih
Shiao, Chih-Chung
author_sort Huang, Ya-Ting
collection PubMed
description It is unclear whether serum procalcitonin (PCT) levels rise in patients with acute kidney injury (AKI), and it is also unclear whether the elevation of PCT levels in this setting is independent of the existence of infection and impaired renal clearance. We conducted a retrospective study in a regional teaching hospital in Taiwan to evaluate the AKI-predictive ability of serum PCT among critically ill patients. We enrolled 330 patients (mean age, 70.5 ± 16.4 years; 57.0% men) who were admitted to the intensive care unit (ICU) from 1 July 2016, to 31 December 2016, and who had serum PCT measurement performed within 24 h after ICU admission. We used the generalized additive model and generalized linear model to evaluate the association of serum PCT levels and renal function variables. In addition, we used the multivariate logistic regression method to demonstrate serum PCT level as an independent predictor of AKI in both the non-infected patients (odds ratio (OR) = 1.38, 95% confidence interval (CI) = 1.12–1.71, p = 0.003) and the infected patients (OR = 1.23, 95% CI = 1.03–1.46, p = 0.020). In conclusion, serum PCT level at ICU admission is an independent predictor of developing AKI irrespective of infection among critically ill patients.
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spelling pubmed-73554462020-07-23 Independent Predictive Ability of Procalcitonin of Acute Kidney Injury among Critically Ill Patients Huang, Ya-Ting Lai, Min-Yu Kan, Wei-Chih Shiao, Chih-Chung J Clin Med Article It is unclear whether serum procalcitonin (PCT) levels rise in patients with acute kidney injury (AKI), and it is also unclear whether the elevation of PCT levels in this setting is independent of the existence of infection and impaired renal clearance. We conducted a retrospective study in a regional teaching hospital in Taiwan to evaluate the AKI-predictive ability of serum PCT among critically ill patients. We enrolled 330 patients (mean age, 70.5 ± 16.4 years; 57.0% men) who were admitted to the intensive care unit (ICU) from 1 July 2016, to 31 December 2016, and who had serum PCT measurement performed within 24 h after ICU admission. We used the generalized additive model and generalized linear model to evaluate the association of serum PCT levels and renal function variables. In addition, we used the multivariate logistic regression method to demonstrate serum PCT level as an independent predictor of AKI in both the non-infected patients (odds ratio (OR) = 1.38, 95% confidence interval (CI) = 1.12–1.71, p = 0.003) and the infected patients (OR = 1.23, 95% CI = 1.03–1.46, p = 0.020). In conclusion, serum PCT level at ICU admission is an independent predictor of developing AKI irrespective of infection among critically ill patients. MDPI 2020-06-21 /pmc/articles/PMC7355446/ /pubmed/32575833 http://dx.doi.org/10.3390/jcm9061939 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Ya-Ting
Lai, Min-Yu
Kan, Wei-Chih
Shiao, Chih-Chung
Independent Predictive Ability of Procalcitonin of Acute Kidney Injury among Critically Ill Patients
title Independent Predictive Ability of Procalcitonin of Acute Kidney Injury among Critically Ill Patients
title_full Independent Predictive Ability of Procalcitonin of Acute Kidney Injury among Critically Ill Patients
title_fullStr Independent Predictive Ability of Procalcitonin of Acute Kidney Injury among Critically Ill Patients
title_full_unstemmed Independent Predictive Ability of Procalcitonin of Acute Kidney Injury among Critically Ill Patients
title_short Independent Predictive Ability of Procalcitonin of Acute Kidney Injury among Critically Ill Patients
title_sort independent predictive ability of procalcitonin of acute kidney injury among critically ill patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355446/
https://www.ncbi.nlm.nih.gov/pubmed/32575833
http://dx.doi.org/10.3390/jcm9061939
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