Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung Cancer

Human airways are continuously colonized by microaspiration of microbiota. Less is known about the presence, origin and composition of microbiota in the lung parenchyma. In a study of 13 patients undergoing surgery for peripheral lung cancer microbiota composition was comparatively evaluated in uppe...

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Autores principales: Reinhold, Lena, Möllering, Andreas, Wallis, Sönke, Palade, Emanuel, Schäfer, Kathrin, Drömann, Daniel, Rupp, Jan, Graspeuntner, Simon, Dalhoff, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355471/
https://www.ncbi.nlm.nih.gov/pubmed/32466482
http://dx.doi.org/10.3390/microorganisms8060794
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author Reinhold, Lena
Möllering, Andreas
Wallis, Sönke
Palade, Emanuel
Schäfer, Kathrin
Drömann, Daniel
Rupp, Jan
Graspeuntner, Simon
Dalhoff, Klaus
author_facet Reinhold, Lena
Möllering, Andreas
Wallis, Sönke
Palade, Emanuel
Schäfer, Kathrin
Drömann, Daniel
Rupp, Jan
Graspeuntner, Simon
Dalhoff, Klaus
author_sort Reinhold, Lena
collection PubMed
description Human airways are continuously colonized by microaspiration of microbiota. Less is known about the presence, origin and composition of microbiota in the lung parenchyma. In a study of 13 patients undergoing surgery for peripheral lung cancer microbiota composition was comparatively evaluated in upper airway, lower airway and lung tissue samples using 16S rDNA analysis. Bacterial density decreased stepwise from upper to lower airways and tissue. On a taxonomic level upper and lower airway microbiota were similar whereas lung tissue showed marked dissimilarities compared to lower airways that may reflect different environmental conditions shaping local microbiota and host immunity.
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spelling pubmed-73554712020-07-23 Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung Cancer Reinhold, Lena Möllering, Andreas Wallis, Sönke Palade, Emanuel Schäfer, Kathrin Drömann, Daniel Rupp, Jan Graspeuntner, Simon Dalhoff, Klaus Microorganisms Communication Human airways are continuously colonized by microaspiration of microbiota. Less is known about the presence, origin and composition of microbiota in the lung parenchyma. In a study of 13 patients undergoing surgery for peripheral lung cancer microbiota composition was comparatively evaluated in upper airway, lower airway and lung tissue samples using 16S rDNA analysis. Bacterial density decreased stepwise from upper to lower airways and tissue. On a taxonomic level upper and lower airway microbiota were similar whereas lung tissue showed marked dissimilarities compared to lower airways that may reflect different environmental conditions shaping local microbiota and host immunity. MDPI 2020-05-26 /pmc/articles/PMC7355471/ /pubmed/32466482 http://dx.doi.org/10.3390/microorganisms8060794 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Reinhold, Lena
Möllering, Andreas
Wallis, Sönke
Palade, Emanuel
Schäfer, Kathrin
Drömann, Daniel
Rupp, Jan
Graspeuntner, Simon
Dalhoff, Klaus
Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung Cancer
title Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung Cancer
title_full Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung Cancer
title_fullStr Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung Cancer
title_full_unstemmed Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung Cancer
title_short Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung Cancer
title_sort dissimilarity of airway and lung tissue microbiota in smokers undergoing surgery for lung cancer
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355471/
https://www.ncbi.nlm.nih.gov/pubmed/32466482
http://dx.doi.org/10.3390/microorganisms8060794
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