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Outcome in Patients with Partial and Full-Thickness Cheek Defects following Free Flap Reconstruction—A Multicentric Analysis of 47 Cases

The objective of this study was to evaluate whether the extent of tumor resection and free flap reconstruction influences functional outcome and complications in patients with solid malignancies of the cheek. Therefore, we retrospectively assessed recipient site complications and functional outcomes...

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Autores principales: Janik, Stefan, Eljazzar, Rachelle, Faisal, Muhammad, Grasl, Stefan, Vyskocil, Erich, Miles, Brett A., Brunner, Markus, Seemann, Rudolf, Erovic, Boban M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355530/
https://www.ncbi.nlm.nih.gov/pubmed/32512827
http://dx.doi.org/10.3390/jcm9061740
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author Janik, Stefan
Eljazzar, Rachelle
Faisal, Muhammad
Grasl, Stefan
Vyskocil, Erich
Miles, Brett A.
Brunner, Markus
Seemann, Rudolf
Erovic, Boban M.
author_facet Janik, Stefan
Eljazzar, Rachelle
Faisal, Muhammad
Grasl, Stefan
Vyskocil, Erich
Miles, Brett A.
Brunner, Markus
Seemann, Rudolf
Erovic, Boban M.
author_sort Janik, Stefan
collection PubMed
description The objective of this study was to evaluate whether the extent of tumor resection and free flap reconstruction influences functional outcome and complications in patients with solid malignancies of the cheek. Therefore, we retrospectively assessed recipient site complications and functional outcomes in 47 patients with solid malignancies of the cheek who underwent either partial (n = 30; 63.8%) or full-thickness (n = 17; 36.2%) cheek resection with free flap reconstruction. Complications occurred in 12 (70.6%) patients after full thickness resections with creation of through-and-through defects compared to 14 (70.6%) patients with partial defects (p = 0.138). Among those 26 patients (55.3%), major recipient site complications, like development of salivary fistula or free flap loss, were observed in 10 (21.3%) and 2 (4.3%) cases, respectively, while minor complications, like wound dehiscence and local infections, were found in 14 (29.8%) and 9 (19.1%) patients. Complications were noticed particularly after reconstruction of suborbital defects (69.2%; p = 0.268), of which occurrence of salivary fistulae was the most common (46.2%; p = 0.035). Similarly, functional outcomes including oral incompetence, ectropion, and trismus were not affected by the extent of resection (p = 0.766). However, oral incompetence was higher in patients with tumors originating from the oral cavity (p = 0.020) and after the performance of mandibulectomy (p = 0.003). Overall, there was no difference in functional outcome or recipient site morbidity between tumor resections resulting in full-thickness and partial defects.
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spelling pubmed-73555302020-07-23 Outcome in Patients with Partial and Full-Thickness Cheek Defects following Free Flap Reconstruction—A Multicentric Analysis of 47 Cases Janik, Stefan Eljazzar, Rachelle Faisal, Muhammad Grasl, Stefan Vyskocil, Erich Miles, Brett A. Brunner, Markus Seemann, Rudolf Erovic, Boban M. J Clin Med Article The objective of this study was to evaluate whether the extent of tumor resection and free flap reconstruction influences functional outcome and complications in patients with solid malignancies of the cheek. Therefore, we retrospectively assessed recipient site complications and functional outcomes in 47 patients with solid malignancies of the cheek who underwent either partial (n = 30; 63.8%) or full-thickness (n = 17; 36.2%) cheek resection with free flap reconstruction. Complications occurred in 12 (70.6%) patients after full thickness resections with creation of through-and-through defects compared to 14 (70.6%) patients with partial defects (p = 0.138). Among those 26 patients (55.3%), major recipient site complications, like development of salivary fistula or free flap loss, were observed in 10 (21.3%) and 2 (4.3%) cases, respectively, while minor complications, like wound dehiscence and local infections, were found in 14 (29.8%) and 9 (19.1%) patients. Complications were noticed particularly after reconstruction of suborbital defects (69.2%; p = 0.268), of which occurrence of salivary fistulae was the most common (46.2%; p = 0.035). Similarly, functional outcomes including oral incompetence, ectropion, and trismus were not affected by the extent of resection (p = 0.766). However, oral incompetence was higher in patients with tumors originating from the oral cavity (p = 0.020) and after the performance of mandibulectomy (p = 0.003). Overall, there was no difference in functional outcome or recipient site morbidity between tumor resections resulting in full-thickness and partial defects. MDPI 2020-06-04 /pmc/articles/PMC7355530/ /pubmed/32512827 http://dx.doi.org/10.3390/jcm9061740 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Janik, Stefan
Eljazzar, Rachelle
Faisal, Muhammad
Grasl, Stefan
Vyskocil, Erich
Miles, Brett A.
Brunner, Markus
Seemann, Rudolf
Erovic, Boban M.
Outcome in Patients with Partial and Full-Thickness Cheek Defects following Free Flap Reconstruction—A Multicentric Analysis of 47 Cases
title Outcome in Patients with Partial and Full-Thickness Cheek Defects following Free Flap Reconstruction—A Multicentric Analysis of 47 Cases
title_full Outcome in Patients with Partial and Full-Thickness Cheek Defects following Free Flap Reconstruction—A Multicentric Analysis of 47 Cases
title_fullStr Outcome in Patients with Partial and Full-Thickness Cheek Defects following Free Flap Reconstruction—A Multicentric Analysis of 47 Cases
title_full_unstemmed Outcome in Patients with Partial and Full-Thickness Cheek Defects following Free Flap Reconstruction—A Multicentric Analysis of 47 Cases
title_short Outcome in Patients with Partial and Full-Thickness Cheek Defects following Free Flap Reconstruction—A Multicentric Analysis of 47 Cases
title_sort outcome in patients with partial and full-thickness cheek defects following free flap reconstruction—a multicentric analysis of 47 cases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355530/
https://www.ncbi.nlm.nih.gov/pubmed/32512827
http://dx.doi.org/10.3390/jcm9061740
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