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Candida and Candidiasis—Opportunism Versus Pathogenicity: A Review of the Virulence Traits
One of the most important questions in microbiology nowadays, is how apparently harmless, commensal yeasts like Candida spp. can cause a rising number of infections. The occurrence of the disease requires firstly the attachment to the host cells, followed by the invasion of the tissue. The adaptabil...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355540/ https://www.ncbi.nlm.nih.gov/pubmed/32517179 http://dx.doi.org/10.3390/microorganisms8060857 |
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author | Ciurea, Cristina Nicoleta Kosovski, Irina-Bianca Mare, Anca Delia Toma, Felicia Pintea-Simon, Ionela Anca Man, Adrian |
author_facet | Ciurea, Cristina Nicoleta Kosovski, Irina-Bianca Mare, Anca Delia Toma, Felicia Pintea-Simon, Ionela Anca Man, Adrian |
author_sort | Ciurea, Cristina Nicoleta |
collection | PubMed |
description | One of the most important questions in microbiology nowadays, is how apparently harmless, commensal yeasts like Candida spp. can cause a rising number of infections. The occurrence of the disease requires firstly the attachment to the host cells, followed by the invasion of the tissue. The adaptability translates into a rapid ability to respond to stress factors, to take up nutrients or to multiply under different conditions. By forming complex intracellular networks such as biofilms, Candida spp. become not only more refractive to antifungal therapies but also more prone to cause disease. The inter-microbial interactions can enhance the virulence of a strain. In vivo, the fungal cells face a multitude of challenges and, as a result, they develop complex strategies serving one ultimate goal: survival. This review presents the virulence factors of the most important Candida spp., contributing to a better understanding of the onset of candidiasis and raising awareness of the highly complex interspecies interactions that can change the outcome of the disease. |
format | Online Article Text |
id | pubmed-7355540 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73555402020-07-23 Candida and Candidiasis—Opportunism Versus Pathogenicity: A Review of the Virulence Traits Ciurea, Cristina Nicoleta Kosovski, Irina-Bianca Mare, Anca Delia Toma, Felicia Pintea-Simon, Ionela Anca Man, Adrian Microorganisms Review One of the most important questions in microbiology nowadays, is how apparently harmless, commensal yeasts like Candida spp. can cause a rising number of infections. The occurrence of the disease requires firstly the attachment to the host cells, followed by the invasion of the tissue. The adaptability translates into a rapid ability to respond to stress factors, to take up nutrients or to multiply under different conditions. By forming complex intracellular networks such as biofilms, Candida spp. become not only more refractive to antifungal therapies but also more prone to cause disease. The inter-microbial interactions can enhance the virulence of a strain. In vivo, the fungal cells face a multitude of challenges and, as a result, they develop complex strategies serving one ultimate goal: survival. This review presents the virulence factors of the most important Candida spp., contributing to a better understanding of the onset of candidiasis and raising awareness of the highly complex interspecies interactions that can change the outcome of the disease. MDPI 2020-06-06 /pmc/articles/PMC7355540/ /pubmed/32517179 http://dx.doi.org/10.3390/microorganisms8060857 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ciurea, Cristina Nicoleta Kosovski, Irina-Bianca Mare, Anca Delia Toma, Felicia Pintea-Simon, Ionela Anca Man, Adrian Candida and Candidiasis—Opportunism Versus Pathogenicity: A Review of the Virulence Traits |
title | Candida and Candidiasis—Opportunism Versus Pathogenicity: A Review of the Virulence Traits |
title_full | Candida and Candidiasis—Opportunism Versus Pathogenicity: A Review of the Virulence Traits |
title_fullStr | Candida and Candidiasis—Opportunism Versus Pathogenicity: A Review of the Virulence Traits |
title_full_unstemmed | Candida and Candidiasis—Opportunism Versus Pathogenicity: A Review of the Virulence Traits |
title_short | Candida and Candidiasis—Opportunism Versus Pathogenicity: A Review of the Virulence Traits |
title_sort | candida and candidiasis—opportunism versus pathogenicity: a review of the virulence traits |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355540/ https://www.ncbi.nlm.nih.gov/pubmed/32517179 http://dx.doi.org/10.3390/microorganisms8060857 |
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