Cryo-EM Structure and Molecular Dynamics Analysis of the Fluoroquinolone Resistant Mutant of the AcrB Transporter from Salmonella

Salmonella is an important genus of Gram-negative pathogens, treatment of which has become problematic due to increases in antimicrobial resistance. This is partly attributable to the overexpression of tripartite efflux pumps, particularly the constitutively expressed AcrAB-TolC. Despite its clinica...

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Detalles Bibliográficos
Autores principales: Johnson, Rachel M., Fais, Chiara, Parmar, Mayuriben, Cheruvara, Harish, Marshall, Robert L., Hesketh, Sophie J., Feasey, Matthew C., Ruggerone, Paolo, Vargiu, Attilio V., Postis, Vincent L. G., Muench, Stephen P., Bavro, Vassiliy N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355581/
https://www.ncbi.nlm.nih.gov/pubmed/32585951
http://dx.doi.org/10.3390/microorganisms8060943

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