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Extract of Juniperus indica Bertol Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade

Oral cancer—a type of head and neck cancer—is estimated to be the fifth most common cancer in Taiwan. However, efficacious therapies for oral cancer are still lacking due to drug resistance and recurrence. Consequently, the identification of new anticancer agents for clinical treatment is needed. Ju...

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Autores principales: Huang, Xiao-Fan, Chang, Kai-Fu, Lee, Shan-Chih, Li, Chia-Yu, Liao, Hung-Hsiu, Hsieh, Ming-Chang, Tsai, Nu-Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355628/
https://www.ncbi.nlm.nih.gov/pubmed/32545807
http://dx.doi.org/10.3390/molecules25122746
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author Huang, Xiao-Fan
Chang, Kai-Fu
Lee, Shan-Chih
Li, Chia-Yu
Liao, Hung-Hsiu
Hsieh, Ming-Chang
Tsai, Nu-Man
author_facet Huang, Xiao-Fan
Chang, Kai-Fu
Lee, Shan-Chih
Li, Chia-Yu
Liao, Hung-Hsiu
Hsieh, Ming-Chang
Tsai, Nu-Man
author_sort Huang, Xiao-Fan
collection PubMed
description Oral cancer—a type of head and neck cancer—is estimated to be the fifth most common cancer in Taiwan. However, efficacious therapies for oral cancer are still lacking due to drug resistance and recurrence. Consequently, the identification of new anticancer agents for clinical treatment is needed. Juniperus indica Bertol is a plant of the Juniperus genus often used as a treatment in traditional medicine due to its anti-inflammatory, antibacterial and diuretic functions. The biofunctions of Juniperus indica Bertol including its anticancer potential, have not been fully explored. As a result, the aim of this research was to investigate the anticancer activity of Juniperus indica Bertol extract (JIB extract) and determine whether JIB extract has synergistic effects with cisplatin in oral cancer. These results are the first to demonstrate that JIB extract exhibits anticancer capacity and synergizes with cisplatin to treat oral cancer. Our findings indicate that JIB extract has a potential to develop anticancer agent and chemo therapeutic adjuvant for oral cancer.
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spelling pubmed-73556282020-07-23 Extract of Juniperus indica Bertol Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade Huang, Xiao-Fan Chang, Kai-Fu Lee, Shan-Chih Li, Chia-Yu Liao, Hung-Hsiu Hsieh, Ming-Chang Tsai, Nu-Man Molecules Article Oral cancer—a type of head and neck cancer—is estimated to be the fifth most common cancer in Taiwan. However, efficacious therapies for oral cancer are still lacking due to drug resistance and recurrence. Consequently, the identification of new anticancer agents for clinical treatment is needed. Juniperus indica Bertol is a plant of the Juniperus genus often used as a treatment in traditional medicine due to its anti-inflammatory, antibacterial and diuretic functions. The biofunctions of Juniperus indica Bertol including its anticancer potential, have not been fully explored. As a result, the aim of this research was to investigate the anticancer activity of Juniperus indica Bertol extract (JIB extract) and determine whether JIB extract has synergistic effects with cisplatin in oral cancer. These results are the first to demonstrate that JIB extract exhibits anticancer capacity and synergizes with cisplatin to treat oral cancer. Our findings indicate that JIB extract has a potential to develop anticancer agent and chemo therapeutic adjuvant for oral cancer. MDPI 2020-06-13 /pmc/articles/PMC7355628/ /pubmed/32545807 http://dx.doi.org/10.3390/molecules25122746 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Xiao-Fan
Chang, Kai-Fu
Lee, Shan-Chih
Li, Chia-Yu
Liao, Hung-Hsiu
Hsieh, Ming-Chang
Tsai, Nu-Man
Extract of Juniperus indica Bertol Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade
title Extract of Juniperus indica Bertol Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade
title_full Extract of Juniperus indica Bertol Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade
title_fullStr Extract of Juniperus indica Bertol Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade
title_full_unstemmed Extract of Juniperus indica Bertol Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade
title_short Extract of Juniperus indica Bertol Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade
title_sort extract of juniperus indica bertol synergizes with cisplatin to inhibit oral cancer cell growth via repression of cell cycle progression and activation of the caspase cascade
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355628/
https://www.ncbi.nlm.nih.gov/pubmed/32545807
http://dx.doi.org/10.3390/molecules25122746
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