Development of a DNA Vaccine for Melanoma Metastasis by Inhalation Based on an Analysis of Transgene Expression Characteristics of Naked pDNA and a Ternary Complex in Mouse Lung Tissues

The present study investigated a pulmonary delivery system of plasmid DNA (pDNA) and its application to melanoma DNA vaccines. pCMV-Luc, pEGFP-C1, and pZsGreen were used as a model pDNA to evaluate transfection efficacy after inhalation in mice. Naked pDNA and a ternary complex, consisting of pDNA,...

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Detalles Bibliográficos
Autores principales: Kodama, Yukinobu, Nakashima, Mikiro, Nagahara, Tadayuki, Oyama, Natsuko, Hashizume, Junya, Nakagawa, Hiroo, Harasawa, Hitomi, Muro, Takahiro, Kurosaki, Tomoaki, Yamashita, Chikamasa, Hashida, Mitsuru, Kitahara, Takashi, Sasaki, Hitoshi, Kawakami, Shigeru, Nakamura, Tadahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355686/
https://www.ncbi.nlm.nih.gov/pubmed/32545209
http://dx.doi.org/10.3390/pharmaceutics12060540

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